Man1c1 mannosidase, alpha, class 1C, member 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Man1c1provided by MGI
Official Full Name: mannosidase, alpha, class 1C, member 1provided by MGI
Primary source: MGI:MGI:2446214
See related: Ensembl:ENSMUSG00000037306 AllianceGenome:MGI:2446214
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable calcium ion binding activity and mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Predicted to be involved in N-glycan processing. Predicted to act upstream of or within mannose metabolic process and proteoglycan biosynthetic process. Predicted to be located in Golgi apparatus. Predicted to be active in Golgi membrane and endoplasmic reticulum. Is expressed in several structures, including cerebellum; genitourinary system; gut; hemolymphoid system gland; and liver. Orthologous to human MAN1C1 (mannosidase alpha class 1C member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 8.3), cerebellum adult (RPKM 7.8) and 26 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 4; 4 D3

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (134289001..134432987, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (134561690..134704290, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

MAN1C1 (e-PCR)
- UniSTS:503305

NoName (e-PCR)
- UniSTS:235059

Man1c1 (e-PCR), detects polymorphism
- UniSTS:499072

D4Mit70 (e-PCR), detects polymorphism
- UniSTS:130188

AI593348 (e-PCR)
- UniSTS:164264

Homology

Homologs of the Man1c1 gene: The Man1c1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, and frog.
Orthologs from Annotation Pipeline: 342 organisms have orthologs with human gene Man1c1
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in N-glycan processing	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within mannose metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within proteoglycan biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: mannosyl-oligosaccharide 1,2-alpha-mannosidase IC

NP_997120.1

EC 3.2.1.113

XP_006538820.1

EC 3.2.1.113

XP_036019960.1

EC 3.2.1.113

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_207237.3 → NP_997120.1 mannosyl-oligosaccharide 1,2-alpha-mannosidase IC

See identical proteins and their annotated locations for NP_997120.1

Status: VALIDATED

Source sequence(s)

AL627122, AL669982

Consensus CDS

CCDS18776.1

UniProtKB/TrEMBL

Q6NXK9

Related

ENSMUSP00000050979.7, ENSMUST00000054096.13

Conserved Domains (1) summary

pfam01532
Location:176 → 612

Glyco_hydro_47; Glycosyl hydrolase family 47

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

134289001..134432987 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036164067.1 → XP_036019960.1 mannosyl-oligosaccharide 1,2-alpha-mannosidase IC isoform X1

Conserved Domains (1) summary

pfam01532
Location:176 → 656

Glyco_hydro_47; Glycosyl hydrolase family 47
XM_006538757.5 → XP_006538820.1 mannosyl-oligosaccharide 1,2-alpha-mannosidase IC isoform X2

Conserved Domains (1) summary

pfam01532
Location:9 → 445

Glyco_hydro_47; Glycosyl hydrolase family 47