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ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese dependent [ Homo sapiens (human) ]

Gene ID: 56985, updated on 13-May-2022

Summary

Official Symbol
ADPRMprovided by HGNC
Official Full Name
ADP-ribose/CDP-alcohol diphosphatase, manganese dependentprovided by HGNC
Primary source
HGNC:HGNC:30925
See related
Ensembl:ENSG00000170222 AllianceGenome:HGNC:30925
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MDS006; C17orf48; NBLA03831
Summary
Predicted to enable 2',3'-cyclic-nucleotide 2'-phosphodiesterase activity; manganese ion binding activity; and pyrophosphatase activity. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in lymph node (RPKM 8.5), prostate (RPKM 8.3) and 25 other tissues See more
Orthologs
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Genomic context

See ADPRM in Genome Data Viewer
Location:
17p13.1
Exon count:
4
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (10697594..10711558)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (10605146..10619111)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (10600911..10614875)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903927 Neighboring gene myosin heavy chain 3 Neighboring gene synthesis of cytochrome C oxidase 1 Neighboring gene Sharpr-MPRA regulatory region 5903 Neighboring gene transmembrane protein 220 Neighboring gene mago homolog 2, pseudogene Neighboring gene TMEM220 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 1671

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of chromosome 17 open reading frame 48 (C17orf48) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 2',3'-cyclic-nucleotide 2'-phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ADP-ribose diphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables CDP-glycerol diphosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables manganese ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
manganese-dependent ADP-ribose/CDP-alcohol diphosphatase
Names
ADP-ribose/CDP-alcohol pyrophosphatase
ADPRibase-Mn
CDP-choline phosphohydrolase
NP_064618.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_020233.5NP_064618.3  manganese-dependent ADP-ribose/CDP-alcohol diphosphatase

    See identical proteins and their annotated locations for NP_064618.3

    Status: VALIDATED

    Source sequence(s)
    AB073393, AC002347, DA280275, DA305828
    Consensus CDS
    CCDS11159.2
    UniProtKB/Swiss-Prot
    Q3LIE5
    UniProtKB/TrEMBL
    W0NWJ0
    Related
    ENSP00000369099.4, ENST00000379774.5
    Conserved Domains (2) summary
    cd07396
    Location:18322
    MPP_Nbla03831; Homo sapiens Nbla03831 and related proteins, metallophosphatase domain
    pfam00149
    Location:69280
    Metallophos; Calcineurin-like phosphoesterase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    10697594..10711558
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    10605146..10619111
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)