4FBK,4TUI,1S3M,1T70,3THN,1V73,4H1S,1XZW,3KBP,1WAR,3GVE,1S95,1T71


Conserved Protein Domain Family
Metallophos

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pfam00149: Metallophos (this model, PSSM-Id:278574 is obsolete and has been replaced by 395097)
Click on image for an interactive view with Cn3D
Calcineurin-like phosphoesterase
This family includes a diverse range of phosphoesterases, including protein phosphoserine phosphatases, nucleotidases, sphingomyelin phosphodiesterases and 2'-3' cAMP phosphodiesterases as well as nucleases such as bacterial SbcD or yeast MRE11. The most conserved regions in this superfamily centre around the metal chelating residues.
Statistics
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PSSM-Id: 278574
View PSSM: pfam00149
Aligned: 324 rows
Threshold Bit Score: 28.8906
Threshold Setting Gi: 121726805
Created: 10-Jun-2015
Updated: 5-Aug-2015
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
4FBK_A         77 IRILISSDPHvgyge---------------kdpvrGNDSFVSFNEIL----EI--ARERDVDMILl-gGDIFHDNkpsrk 134  fission yeast
Q9ZMW9         23 IVFLETSDIHgrlfsyd-----------yavgeqkPNNGLTRIATLIk---KQ--RAE-NKNVVLidsGDLLQGN----- 80   Helicobacter ...
Q9X6T9         37 LSILHINDHHsylephetri------nlngqqtkvDIGGFSAVNAKLn---KL--RKKYKNPLVLh-aGDAITGT----- 99   Haemophilus i...
Q9RX10         36 VTVVGLNDFHgnleptsfagvmvpdpkdptkqvklTTGGIEVIGGYLd---QE--RAK-NANLTFvgaGDLIGAS----- 104  Deinococcus r...
P96011         33 LIVGILPDTQgg----------------------gDNIAIHPMEAVLa---KH--QAE-GVNLVIp-vGDLTDKGstk-- 81   Shewanella sp...
O64245          3 KRIVVISDTQ---------------------------IPFDDRKQLKa---VVgfIGDTQPDEVVh-iGDLMDYPsp--- 48   Mycobacterium...
WP_003230532   47 LTIFFISDIH----------------------------KRLIDQDLLe---KA--RSH-APHLVIi-gGDLAEGG----- 86   Bacillus
WP_003244999  568 LRILSMNDLHgkidqqyeld------ldgngtvdgTFGRMDYAAAYLk---EK--KAEKKNSLIVh-aGDMIGGS----- 630  Bacillus subt...
WP_010881553   34 LTIIHINDHHshlepeplel------avagerlraAVGGYAALVHEIq---RL--RAESKNALVLh-aGDALIGT----- 96   Treponema pal...
WP_038428611  622 LTVMHTNDTH---------------------------AHLDDAARRMtkinEV--RSETNHNILLd-aGDVFSGD----- 666  Bacillus subt...
4FBK_A        135 alyqalrslrlnclgdkpcelellsDTSLTTGDTaVCNINyldpninvaiPV----FSIHGNHD----------DPSGDG 200  fission yeast
Q9ZMW9         81 -------------------------SAELFNDEPiHPLVRa--------eNDlkfdIRVLGNHEfnfskdflekNIKGFN 127  Helicobacter ...
Q9X6T9        100 -------------------------LYFTLFGGSaDAAVM----------NAgnfhYFTLGNHEfd-------aGNEGLL 137  Haemophilus i...
Q9RX10        105 -------------------------PVTSSLLRD-EPSVIg--------lSKlgmqYSSLGNHEfd-------qGYKELL 143  Deinococcus r...
P96011         82 ----------------------ewaQWRSIAEKY-QAQGM----------EF----LPVMGNHEts------haYTVEWI 118  Shewanella sp...
O64245         49 ------------------------sRWTKGSSEEfAQRIKpdse---qakTRf--lAPLRAVYDgpvgv-hegnHDRRPF 98   Mycobacterium...
WP_003230532   87 -------------------------VPSARIEENiKRLVHfg-------vPI----VFVWGNNDye-------vRQHKLY 123  Bacillus
WP_003244999  631 -------------------------SPVSSLLQD-EPTVEl--------mEDigfdVGTVGNHEfd-------eGTDELL 669  Bacillus subt...
WP_010881553   97 -------------------------LYSTLFRGRaDAVLM----------NHagfdFFTLGNHEfd-------nGNEGLK 134  Treponema pal...
WP_038428611  667 -------------------------LYFTKWNGLaDLKMM----------NMmgydAMTFGNHEfd-------kGPTVLS 704  Bacillus subt...
4FBK_A        201 RYSALD---ILQVtg-------lVNYFGRVPEND---------NIVVspillQKGFTKLAlygisn-----vrderlYHS 256  fission yeast
Q9ZMW9        128 GDVVNA---NIIKia-------dNKPFVKPYIIK---------KIDG-----VRVAVVGFlvphvpt----weastpEHF 179  Helicobacter ...
Q9X6T9        138 KLLEPL---KIPVls-----------aNVIPDKSs--------ILYNkwkpyDIFTVDGEk----------------IAI 179  Haemophilus i...
Q9RX10        144 RMQNGGcdsNAPDkackfqnpypRATFSWLGANVev-----kaTGKPalpayGIQEIGGAriafig-----avtkttPTI 213  Deinococcus r...
P96011        119 ENMRHYipeDAIHmp-------tAEWLNYYIIRE-----------NTlviglAYYNLPIA-------------------- 160  Shewanella sp...
O64245         99 DYLHKF---APALve-------yADQFKFENLLD---------FDGF-----GVTVLPEFyk------------------ 136  Mycobacterium...
WP_003230532  124 SIFKAH---------------------GVITLRNe-----------------SVPFSYNG-----------------HTI 148  Bacillus
WP_003244999  670 RILNGGdhpKGTSgy-------dGQNFPLVCANCkm-----ksTGEPflpayDIINVEGVpvafigvv--tqsaagmVMP 735  Bacillus subt...
WP_010881553  135 EFLHYL---EVPVls-----------aNVVPNAAs--------TLHGlwkpsAIVERAGEr----------------IGV 176  Treponema pal...
WP_038428611  705 DFLSGNsatVDPAnr-------yHFEAPEFPIVSanvdvsnepKLKSfvkkpQTFTAGEKkeagihpyilldvdgekVAV 777  Bacillus subt...
4FBK_A        257 FRENKVKFLRPDLYr----DEWFNL----------LTVHQNHSAHT---PTSYLPESFIQ-------DF----------- 301  fission yeast
Q9ZMW9        180 AGLEFLDAEEAL-------KKTLSElk------gkYDILIGAFHLG---REDEKGGDGIP-------DLakk-------- 228  Helicobacter ...
Q9X6T9        180 IGLDTVNKTVNSSSpg-kdVKFYDEiataq-imanALKQQGINKII---LLSHAGSEKNI-------EIaqk-------- 239  Haemophilus i...
Q9RX10        214 VSPDGVADLKFLDEae-siNKYVPElkak---gvdAIIVLIHEGGV---SKDGFDKPACG-------TLtgpivnivnkl 279  Deinococcus r...
P96011        161 -------------------FGWIKDviadnegkfdHIVIASHDGLVg--AKYGQTREQIVqgtkgdnRLfdihkei-rel 218  Shewanella sp...
O64245        137 -----------------vaPGWIST--------------HGHRGGV---RVTQKSADTAY-------NAmqr-------- 167  Mycobacterium...
WP_003230532  149 AIAGVDDIRMEMDHy----EEAIKElde-----sqLNILVCHNPEI---------HEQINed------------------ 192  Bacillus
WP_003244999  736 EGIKNIEFTDEATAvnkaaEELKKKgv-------kAIAVLAHMSAEq--NGNAITGESAD-------LAnkt-------- 791  Bacillus subt...
WP_010881553  177 IGLDTVKKTVESSSpg--kDINFIDeiea---vrrATVEMQQQGVNkiiLLSHAGFEKNC-------EIaqn-------- 236  Treponema pal...
WP_038428611  778 FGLTTEDTATTSSPg---kSIVFNDafet--aqntVKAIQEEEKVNkiiALTHIGHNRDL-------ELakk-------- 837  Bacillus subt...
4FBK_A        302 ---YDFV-LWGHEHEC 313  fission yeast
Q9ZMW9        229 fpqFDII-FAGHEHAV 243  Helicobacter pylori J99
Q9X6T9        240 vndIDVI-VTGDSHYL 254  Haemophilus influenzae
Q9RX10        280 dpaVDAV-ISGHTHQG 294  Deinococcus radiodurans
P96011        219 faeHDVIwVQGHEHMY 234  Shewanella sp. DB6705
O64245        168 -fgTSVI-I-GHTHRQ 180  Mycobacterium phage D29
WP_003230532  193 -dgIDVI-LSGHTHGG 206  Bacillus
WP_003244999  792 dseIDVI-FAAHNHQV 806  Bacillus subtilis
WP_010881553  237 isgIDVI-VSGDTHYL 251  Treponema pallidum
WP_038428611  838 vkgIDLI-IGGHTHTL 852  Bacillus subtilis
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