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Zbtb20 zinc finger and BTB domain containing 20 [ Mus musculus (house mouse) ]

Gene ID: 56490, updated on 21-Apr-2024

Summary

Official Symbol
Zbtb20provided by MGI
Official Full Name
zinc finger and BTB domain containing 20provided by MGI
Primary source
MGI:MGI:1929213
See related
Ensembl:ENSMUSG00000022708 AllianceGenome:MGI:1929213
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
HOF; J20; DPZF; Oda8; ODA-8S; Zfp288; D16Wsu73e; 1300017A20Rik; 7330412A13Rik; A930017C21Rik; Tg(PDGFB-APPSwInd)20Lms
Summary
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and transcription cis-regulatory region binding activity. Involved in several processes, including cellular response to glucose stimulus; positive regulation of glycolytic process; and regulation of gene expression. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Orthologous to human ZBTB20 (zinc finger and BTB domain containing 20). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in genital fat pad adult (RPKM 5.3), heart adult (RPKM 4.7) and 26 other tissues See more
Orthologs
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Genomic context

Location:
16 B4; 16 28.44 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (42728008..43462981)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (42875689..43634392)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4932412D23 gene Neighboring gene predicted gene, 29960 Neighboring gene STARR-seq mESC enhancer starr_40870 Neighboring gene STARR-positive B cell enhancer mm9_chr16:42836127-42836428 Neighboring gene STARR-seq mESC enhancer starr_40871 Neighboring gene STARR-positive B cell enhancer ABC_E52 Neighboring gene predicted gene, 19522 Neighboring gene STARR-seq mESC enhancer starr_40874 Neighboring gene NADH:ubiquinone oxidoreductase core subunit S5, pseudogene Neighboring gene STARR-seq mESC enhancer starr_40875 Neighboring gene STARR-seq mESC enhancer starr_40877 Neighboring gene STARR-seq mESC enhancer starr_40878 Neighboring gene predicted gene, 25873 Neighboring gene ribosomal protein L3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_40879 Neighboring gene RAN guanine nucleotide release factor pseudogene Neighboring gene predicted gene 9968 Neighboring gene STARR-seq mESC enhancer starr_40880 Neighboring gene predicted gene 15713 Neighboring gene STARR-seq mESC enhancer starr_40881 Neighboring gene STARR-positive B cell enhancer mm9_chr16:43507109-43507410 Neighboring gene STARR-seq mESC enhancer starr_40882 Neighboring gene STARR-seq mESC enhancer starr_40883 Neighboring gene STARR-seq mESC enhancer starr_40885 Neighboring gene STARR-positive B cell enhancer ABC_E7450 Neighboring gene STARR-positive B cell enhancer ABC_E4170 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:43690256-43690365 Neighboring gene microRNA 568 Neighboring gene predicted gene, 53956 Neighboring gene T cell immunoreceptor with Ig and ITIM domains

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in cellular response to glucose stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lipid homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of glycolytic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interferon-beta production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of interferon-beta production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interleukin-6 production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of lipid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of tumor necrosis factor production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of immune system process IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
zinc finger and BTB domain-containing protein 20
Names
APP Tg
BTB/POZ domain zinc finger factor HOF
PDGF-APPSwInd
PDGF-hAPP695,751,770V171F, KM670/671NL
POZ/zinc finger transcription factor ODA-8
zinc finger protein 288

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001285805.1NP_001272734.1  zinc finger and BTB domain-containing protein 20 isoform L

    See identical proteins and their annotated locations for NP_001272734.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variant 1 and 3 encode the same isoform (L).
    Source sequence(s)
    BC056446, BI659024
    Consensus CDS
    CCDS28178.1
    UniProtKB/Swiss-Prot
    A6X916, Q8K0L9, Q9DBD4, Q9QZ87
    UniProtKB/TrEMBL
    Q9QZF3
    Conserved Domains (5) summary
    sd00017
    Location:580600
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18208
    Location:79195
    BTB_POZ_ZBTB20_DPZF; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20)
    pfam00096
    Location:634656
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:648673
    zf-H2C2_2; Zinc-finger double domain
    cd20908
    Location:608657
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins
  2. NM_001393397.1NP_001380326.1  zinc finger and BTB domain-containing protein 20 isoform L

    Status: VALIDATED

    Source sequence(s)
    AC120871, CT010512, CT010517
    UniProtKB/Swiss-Prot
    A6X916, Q8K0L9, Q9DBD4, Q9QZ87
    UniProtKB/TrEMBL
    Q9QZF3
    Related
    ENSMUSP00000110342.3, ENSMUST00000114694.9
    Conserved Domains (5) summary
    sd00017
    Location:580600
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18208
    Location:79195
    BTB_POZ_ZBTB20_DPZF; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20)
    pfam00096
    Location:634656
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:648673
    zf-H2C2_2; Zinc-finger double domain
    cd20908
    Location:608657
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins
  3. NM_001393398.1NP_001380327.1  zinc finger and BTB domain-containing protein 20 isoform L

    Status: VALIDATED

    Source sequence(s)
    AC120871, CT010512, CT010517
    UniProtKB/Swiss-Prot
    A6X916, Q8K0L9, Q9DBD4, Q9QZ87
    UniProtKB/TrEMBL
    Q9QZF3
    Conserved Domains (5) summary
    sd00017
    Location:580600
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18208
    Location:79195
    BTB_POZ_ZBTB20_DPZF; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20)
    pfam00096
    Location:634656
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:648673
    zf-H2C2_2; Zinc-finger double domain
    cd20908
    Location:608657
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins
  4. NM_001393399.1NP_001380328.1  zinc finger and BTB domain-containing protein 20 isoform S

    Status: VALIDATED

    Source sequence(s)
    AC120871, CT010512, CT010517
    UniProtKB/TrEMBL
    Q9QZF3
    Conserved Domains (6) summary
    COG5048
    Location:432574
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:507527
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18208
    Location:6122
    BTB_POZ_ZBTB20_DPZF; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20)
    pfam00096
    Location:561583
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:575600
    zf-H2C2_2; Zinc-finger double domain
    cd20908
    Location:535584
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins
  5. NM_019778.2NP_062752.2  zinc finger and BTB domain-containing protein 20 isoform L

    See identical proteins and their annotated locations for NP_062752.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (L).
    Source sequence(s)
    AK005028, BC056446
    Consensus CDS
    CCDS28178.1
    UniProtKB/Swiss-Prot
    A6X916, Q8K0L9, Q9DBD4, Q9QZ87
    UniProtKB/TrEMBL
    Q9QZF3
    Related
    ENSMUSP00000078410.7, ENSMUST00000079441.13
    Conserved Domains (5) summary
    sd00017
    Location:580600
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18208
    Location:79195
    BTB_POZ_ZBTB20_DPZF; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20)
    pfam00096
    Location:634656
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:648673
    zf-H2C2_2; Zinc-finger double domain
    cd20908
    Location:608657
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins
  6. NM_181058.1NP_851401.1  zinc finger and BTB domain-containing protein 20 isoform S

    See identical proteins and their annotated locations for NP_851401.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate 5' UTR exon and the alternate exon containing the translation start site compared to variant 1. The resulting isoform (S) is shorter at the N-terminus compared to isoform L.
    Source sequence(s)
    AK005028, BC056446
    Consensus CDS
    CCDS49851.1
    UniProtKB/TrEMBL
    Q9QZF3
    Related
    ENSMUSP00000110339.2, ENSMUST00000114691.8
    Conserved Domains (6) summary
    COG5048
    Location:432574
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:507527
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18208
    Location:6122
    BTB_POZ_ZBTB20_DPZF; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20)
    pfam00096
    Location:561583
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:575600
    zf-H2C2_2; Zinc-finger double domain
    cd20908
    Location:535584
    SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    42728008..43462981
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)