Conserved Protein Domain Family
BTB_POZ_ZBTB20_DPZF

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cd18208: BTB_POZ_ZBTB20_DPZF 
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 20 (ZBTB20)
ZBTB20, also called dendritic-derived BTB/POZ zinc finger protein (DPZF) or zinc finger protein 288, may be a transcription factor involved in hematopoiesis, oncogenesis, and immune responses. It is an essential regulator of hepatic lipogenesis and may be a therapeutic target for the treatment of fatty liver disease. It also functions as a critical regulator of anterior pituitary development and lactotrope specification. Moreover, it promotes astrocytogenesis during neocortical development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.
Statistics
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PSSM-Id: 349517
Aligned: 7 rows
Threshold Bit Score: 224.174
Created: 14-Sep-2017
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q9HC78        79 HSINLHNFSNSVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSDIEIPSVVSVQSVQKLIDFM 158 human
XP_007062145  97 HSINLHNFSNSVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSDIEIPSVVSVQSVQKLIDFM 176 green sea turtle
NP_001074073   6 HHINLHNFSNSVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSDIEIPSVVSVQSVQKLIDFM 85  zebrafish
XP_017946862   6 HSINLHNFSNSVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSDIEIPSVVSVHAVQKLIDFM 85  tropical clawed...
XP_014350628   6 HSINLHNFSNSVLETLNDQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSDIEIPSVVSVQSVQKLIDFM 85  coelacanth
XP_007901227  35 HSINLHNFSNSVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSDIEIPSVVSVQSVQKLIDFM 114 elephant shark
OCT93628       6 HSINLHNFSNSVLETLNEQRNRGHFCDVTVRIHGSMLRAHRCVLAAGSPFFQDKLLLGYSDIEIPSVVSVHAVQKLIDFM 85  African clawed ...
Q9HC78       159 YSGVLRVSQSEALQILTAASILQIKTVIDECTRIVSQ 195 human
XP_007062145 177 YSGVLRVSQSEALQILTAASILQIKTVIDECTRIVSQ 213 green sea turtle
NP_001074073  86 YSGVLRVSQSEALQILTAASILQIKTVIDECTRIVSQ 122 zebrafish
XP_017946862  86 YSGVLRVSQSEALQILTAASILQIKTVIDECTRIVSQ 122 tropical clawed frog
XP_014350628  86 YSGVLRVSQSEALQILTAASILQIKTVIDECTRIVSQ 122 coelacanth
XP_007901227 115 YSGVLRVSQSEALQILTAASILQIKTVIDECTRIVSQ 151 elephant shark
OCT93628      86 YSGVLRVSQSEALQILTAASILQIKTVIDECTRIVSQ 122 African clawed frog
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