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Sinhcaf SIN3-HDAC complex associated factor [ Mus musculus (house mouse) ]

Gene ID: 56306, updated on 8-Dec-2022

Summary

Official Symbol
Sinhcafprovided by MGI
Official Full Name
SIN3-HDAC complex associated factorprovided by MGI
Primary source
MGI:MGI:1929091
See related
Ensembl:ENSMUSG00000039985 AllianceGenome:MGI:1929091
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tera; Ppcs1; Fam60a; Pptcs1
Summary
Involved in negative regulation of cell differentiation and positive regulation of cell population proliferation. Predicted to be located in nucleus. Predicted to be part of Sin3 complex. Is expressed in 2-cell stage embryo and 4-cell stage embryo. Orthologous to human SINHCAF (SIN3-HDAC complex associated factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E11.5 (RPKM 31.1), CNS E14 (RPKM 11.8) and 12 other tissues See more
Orthologs
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Genomic context

See Sinhcaf in Genome Data Viewer
Location:
6; 6 G3
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (148822555..148847968, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (148921057..148946470, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene caprin family member 2 Neighboring gene predicted gene, 36762 Neighboring gene ribosomal protein S29 pseudogene Neighboring gene RIKEN cDNA 3010003L21 gene Neighboring gene ES cell cis-regulatory motif 1b Neighboring gene predicted gene, 25539

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of Sin3 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of Sin3 complex ISO
Inferred from Sequence Orthology
more info
 
part_of Sin3 complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in nucleus NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
SIN3-HDAC complex-associated factor
Names
family with sequence similarity 60, member A
pluripotent cell-specific 1
protein FAM60A
teratocarcinoma expressed, serine rich

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355645.2NP_001342574.1  SIN3-HDAC complex-associated factor isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC140327
    Consensus CDS
    CCDS20713.1
    UniProtKB/Swiss-Prot
    Q3TLD2
    UniProtKB/TrEMBL
    A0A6P7R1Y0, A0A8C6HZP5
    Related
    ENSMUSP00000107188.2, ENSMUST00000081956.12
    Conserved Domains (1) summary
    pfam15396
    Location:2198
    FAM60A; Protein Family FAM60A
  2. NM_001361398.2NP_001348327.1  SIN3-HDAC complex-associated factor isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC140327
    Conserved Domains (1) summary
    pfam15396
    Location:296
    FAM60A; Protein Family FAM60A
  3. NM_001411256.1NP_001398185.1  SIN3-HDAC complex-associated factor isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC140327
    UniProtKB/Swiss-Prot
    Q3TLD2
    UniProtKB/TrEMBL
    A0A6P7R1Y0, A0A8C6HZP5
  4. NM_001411257.1NP_001398186.1  SIN3-HDAC complex-associated factor isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC140327
    UniProtKB/Swiss-Prot
    Q3TLD2
    UniProtKB/TrEMBL
    A0A6P7R1Y0, A0A8C6HZP5
  5. NM_001411258.1NP_001398187.1  SIN3-HDAC complex-associated factor isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC140327
    UniProtKB/Swiss-Prot
    Q3TLD2
    UniProtKB/TrEMBL
    A0A6P7R1Y0, A0A8C6HZP5
  6. NM_001411259.1NP_001398188.1  SIN3-HDAC complex-associated factor isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC140327
    UniProtKB/Swiss-Prot
    Q3TLD2
    UniProtKB/TrEMBL
    A0A6P7R1Y0, A0A8C6HZP5
  7. NM_001411260.1NP_001398189.1  SIN3-HDAC complex-associated factor isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC140327
    UniProtKB/Swiss-Prot
    Q3TLD2
    UniProtKB/TrEMBL
    A0A6P7R1Y0, A0A8C6HZP5
  8. NM_001411261.1NP_001398190.1  SIN3-HDAC complex-associated factor isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC140327
    UniProtKB/Swiss-Prot
    Q3TLD2
    UniProtKB/TrEMBL
    A0A6P7R1Y0, A0A8C6HZP5
  9. NM_001411262.1NP_001398191.1  SIN3-HDAC complex-associated factor isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC140327
    UniProtKB/Swiss-Prot
    Q3TLD2
    UniProtKB/TrEMBL
    A0A6P7R1Y0, A0A8C6HZP5
  10. NM_001411263.1NP_001398192.1  SIN3-HDAC complex-associated factor isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC140327
  11. NM_001411264.1NP_001398193.1  SIN3-HDAC complex-associated factor isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC140327
  12. NM_001411265.1NP_001398194.1  SIN3-HDAC complex-associated factor isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC140327
  13. NM_019643.5NP_062617.2  SIN3-HDAC complex-associated factor isoform 1

    See identical proteins and their annotated locations for NP_062617.2

    Status: VALIDATED

    Source sequence(s)
    AC140327
    Consensus CDS
    CCDS20713.1
    UniProtKB/Swiss-Prot
    Q3TLD2, Q8C8M1
    UniProtKB/TrEMBL
    A0A6P7R1Y0, A0A8C6HZP5
    Related
    ENSMUSP00000050952.9, ENSMUST00000054080.15
    Conserved Domains (1) summary
    pfam15396
    Location:2198
    FAM60A; Protein Family FAM60A

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    148822555..148847968 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006507074.5XP_006507137.1  SIN3-HDAC complex-associated factor isoform X1

    UniProtKB/Swiss-Prot
    Q8C8M1
    Related
    ENSMUSP00000145487.2, ENSMUST00000204435.3
    Conserved Domains (1) summary
    pfam15396
    Location:2198
    FAM60A; Protein Family FAM60A
  2. XM_006507075.3XP_006507138.1  SIN3-HDAC complex-associated factor isoform X1

    UniProtKB/Swiss-Prot
    Q8C8M1
    Related
    ENSMUSP00000107187.2, ENSMUST00000111562.8
    Conserved Domains (1) summary
    pfam15396
    Location:2198
    FAM60A; Protein Family FAM60A