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SINHCAF SIN3-HDAC complex associated factor [ Homo sapiens (human) ]

Gene ID: 58516, updated on 5-Aug-2022

Summary

Official Symbol
SINHCAFprovided by HGNC
Official Full Name
SIN3-HDAC complex associated factorprovided by HGNC
Primary source
HGNC:HGNC:30702
See related
Ensembl:ENSG00000139146 MIM:615027; AllianceGenome:HGNC:30702
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L4; TERA; FAM60A; C12orf14
Summary
Involved in negative regulation of cell migration. Part of Sin3 complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in endometrium (RPKM 24.9), lymph node (RPKM 18.1) and 25 other tissues See more
Orthologs
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Genomic context

See SINHCAF in Genome Data Viewer
Location:
12p11.21
Exon count:
9
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (31280584..31326150, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (31157116..31202680, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (31433518..31479084, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein S3A pseudogene Neighboring gene melanoregulin pseudogene 1 Neighboring gene small nucleolar RNA U13 Neighboring gene uncharacterized LOC79857 Neighboring gene U6 spliceosomal RNA Neighboring gene long intergenic non-protein coding RNA 2387 Neighboring gene DENN domain containing 5B Neighboring gene RNA, U6 small nuclear 618, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

General protein information

Preferred Names
SIN3-HDAC complex-associated factor
Names
family with sequence similarity 60 member A
protein FAM60A
tera protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135811.2NP_001129283.1  SIN3-HDAC complex-associated factor

    See identical proteins and their annotated locations for NP_001129283.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AF087885, BC000024, BC004462, DR763430
    Consensus CDS
    CCDS8723.1
    UniProtKB/Swiss-Prot
    Q9BSZ8, Q9NP50
    Conserved Domains (1) summary
    pfam15396
    Location:2198
    FAM60A; Protein Family FAM60A
  2. NM_001135812.2NP_001129284.1  SIN3-HDAC complex-associated factor

    See identical proteins and their annotated locations for NP_001129284.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks a segment in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AK026932, BC004462, DA741767, DR763430
    Consensus CDS
    CCDS8723.1
    UniProtKB/Swiss-Prot
    Q9BSZ8, Q9NP50
    Related
    ENSP00000337477.4, ENST00000337682.9
    Conserved Domains (1) summary
    pfam15396
    Location:2198
    FAM60A; Protein Family FAM60A
  3. NM_021238.3NP_067061.1  SIN3-HDAC complex-associated factor

    See identical proteins and their annotated locations for NP_067061.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different splice site in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    BC000024, BC004462, DR763430
    Consensus CDS
    CCDS8723.1
    UniProtKB/Swiss-Prot
    Q9BSZ8, Q9NP50
    Conserved Domains (1) summary
    pfam15396
    Location:2198
    FAM60A; Protein Family FAM60A

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    31280584..31326150 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017019762.3XP_016875251.1  SIN3-HDAC complex-associated factor isoform X1

    UniProtKB/Swiss-Prot
    Q9BSZ8, Q9NP50
    Conserved Domains (1) summary
    pfam15396
    Location:2198
    FAM60A; Protein Family FAM60A
  2. XM_047429272.1XP_047285228.1  SIN3-HDAC complex-associated factor isoform X1

    UniProtKB/Swiss-Prot
    Q9BSZ8
  3. XM_011520803.3XP_011519105.2  SIN3-HDAC complex-associated factor isoform X1

    UniProtKB/Swiss-Prot
    Q9BSZ8
    Related
    ENSP00000393279.2, ENST00000454658.6

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187587.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    171378..216944 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    31157116..31202680 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)