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SINHCAF SIN3-HDAC complex associated factor [ Homo sapiens (human) ]

Gene ID: 58516, updated on 5-Apr-2020

Summary

Official Symbol
SINHCAFprovided by HGNC
Official Full Name
SIN3-HDAC complex associated factorprovided by HGNC
Primary source
HGNC:HGNC:30702
See related
Ensembl:ENSG00000139146 MIM:615027
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L4; TERA; FAM60A; C12orf14
Expression
Ubiquitous expression in endometrium (RPKM 24.9), lymph node (RPKM 18.1) and 25 other tissues See more
Orthologs

Genomic context

See SINHCAF in Genome Data Viewer
Location:
12p11.21
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (31280584..31326218, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (31433356..31479159, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein S3A pseudogene Neighboring gene melanoregulin pseudogene 1 Neighboring gene uncharacterized LOC79857 Neighboring gene long intergenic non-protein coding RNA 2387 Neighboring gene DENN domain containing 5B Neighboring gene RNA, U6 small nuclear 618, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
negative regulation of cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
Sin3 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Sin3 complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
SIN3-HDAC complex-associated factor
Names
family with sequence similarity 60 member A
protein FAM60A
tera protein homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135811.1NP_001129283.1  SIN3-HDAC complex-associated factor

    See identical proteins and their annotated locations for NP_001129283.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AF087885, BC000024, BC004462, DR763430
    Consensus CDS
    CCDS8723.1
    UniProtKB/Swiss-Prot
    Q9NP50
    Conserved Domains (1) summary
    pfam15396
    Location:2198
    FAM60A; Protein Family FAM60A
  2. NM_001135812.2NP_001129284.1  SIN3-HDAC complex-associated factor

    See identical proteins and their annotated locations for NP_001129284.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks a segment in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    AK026932, BC004462, DA741767, DR763430
    Consensus CDS
    CCDS8723.1
    UniProtKB/Swiss-Prot
    Q9NP50
    Related
    ENSP00000337477.4, ENST00000337682.9
    Conserved Domains (1) summary
    pfam15396
    Location:2198
    FAM60A; Protein Family FAM60A
  3. NM_021238.2NP_067061.1  SIN3-HDAC complex-associated factor

    See identical proteins and their annotated locations for NP_067061.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses a different splice site in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein.
    Source sequence(s)
    BC000024, BC004462, DR763430
    Consensus CDS
    CCDS8723.1
    UniProtKB/Swiss-Prot
    Q9NP50
    Conserved Domains (1) summary
    pfam15396
    Location:2198
    FAM60A; Protein Family FAM60A

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    31280584..31326218 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017019762.2XP_016875251.1  SIN3-HDAC complex-associated factor isoform X2

    UniProtKB/Swiss-Prot
    Q9NP50
    Conserved Domains (1) summary
    pfam15396
    Location:2198
    FAM60A; Protein Family FAM60A
  2. XM_017019759.2XP_016875248.1  SIN3-HDAC complex-associated factor isoform X2

    UniProtKB/Swiss-Prot
    Q9NP50
    Conserved Domains (1) summary
    pfam15396
    Location:2198
    FAM60A; Protein Family FAM60A
  3. XM_011520803.2XP_011519105.1  SIN3-HDAC complex-associated factor isoform X1

    See identical proteins and their annotated locations for XP_011519105.1

    Conserved Domains (1) summary
    pfam15396
    Location:109305
    FAM60A; Protein Family FAM60A
  4. XM_017019761.1XP_016875250.1  SIN3-HDAC complex-associated factor isoform X2

    UniProtKB/Swiss-Prot
    Q9NP50
    Related
    ENSP00000393279.2, ENST00000454658.6
    Conserved Domains (1) summary
    pfam15396
    Location:2198
    FAM60A; Protein Family FAM60A
  5. XM_017019758.2XP_016875247.1  SIN3-HDAC complex-associated factor isoform X2

    UniProtKB/Swiss-Prot
    Q9NP50
    Conserved Domains (1) summary
    pfam15396
    Location:2198
    FAM60A; Protein Family FAM60A
  6. XM_017019760.1XP_016875249.1  SIN3-HDAC complex-associated factor isoform X2

    UniProtKB/Swiss-Prot
    Q9NP50
    Conserved Domains (1) summary
    pfam15396
    Location:2198
    FAM60A; Protein Family FAM60A

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187587.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    171378..216981 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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