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Patz1 POZ (BTB) and AT hook containing zinc finger 1 [ Mus musculus (house mouse) ]

Gene ID: 56218, updated on 8-Dec-2022

Summary

Official Symbol
Patz1provided by MGI
Official Full Name
POZ (BTB) and AT hook containing zinc finger 1provided by MGI
Primary source
MGI:MGI:1891832
See related
Ensembl:ENSMUSG00000020453 AllianceGenome:MGI:1891832
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mazr; Patz; Zfp278; 8430401L15Rik
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in negative regulation of endothelial cell migration and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including T cell differentiation; male gonad development; and spermatogenesis. Located in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; limb bud; nervous system; and sensory organ. Orthologous to human PATZ1 (POZ/BTB and AT hook containing zinc finger 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 44.7), ovary adult (RPKM 21.8) and 26 other tissues See more
Orthologs
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Genomic context

See Patz1 in Genome Data Viewer
Location:
11; 11 A1
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (3239131..3259083)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (3289131..3309083)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene Sfi1 homolog, spindle assembly associated (yeast) Neighboring gene eukaryotic translation initiation factor 4E nuclear import factor 1 Neighboring gene predicted gene, 51877 Neighboring gene developmentally regulated GTP binding protein 1 Neighboring gene predicted gene 12592 Neighboring gene predicted gene 11944 Neighboring gene phosphoinositide-3-kinase interacting protein 1 Neighboring gene LIM motif-containing protein kinase 2 Neighboring gene predicted gene, 51879

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in male germ cell nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

General protein information

Preferred Names
POZ (BTB) and AT hook-containing zinc finger 1
Names
BTB/POZ domain zinc finger transcription factor
POZ-, AT hook-, and zinc finger-containing protein 1
POZ-AT hook-zinc finger protein
protein kinase A RI subunit alpha-associated protein
transcription factor (MAZ-related) MAZR
zinc finger and BTB domain-containing protein 19
zinc finger protein 278

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001253690.1NP_001240619.1  POZ (BTB) and AT hook-containing zinc finger 1 isoform 2

    See identical proteins and their annotated locations for NP_001240619.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) includes an additional exon that causes a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (2) has a distinct and shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AL671968, BC043035
    Consensus CDS
    CCDS56754.1
    UniProtKB/TrEMBL
    A0A6P7RJE8, A0A8C6GET8, Q5NBZ1, Q80XS2
    Related
    ENSMUSP00000091103.6, ENSMUST00000093402.12
    Conserved Domains (6) summary
    COG5048
    Location:381451
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:329406
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:357377
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18207
    Location:14162
    BTB_POZ_ZBTB19_PATZ1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1)
    pfam13465
    Location:369394
    zf-H2C2_2; Zinc-finger double domain
    pfam13912
    Location:442467
    zf-C2H2_6; C2H2-type zinc finger
  2. NM_001253691.1NP_001240620.1  POZ (BTB) and AT hook-containing zinc finger 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) includes an additional exon that causes a frameshift in the 3' coding region, compared to variant 1. The encoded isoform (3) has a distinct and shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AL671968, BC043035, CA327687
    UniProtKB/TrEMBL
    Q80XS2
    Related
    ENSMUSP00000092043.4, ENSMUST00000094471.10
    Conserved Domains (4) summary
    COG5189
    Location:379436
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:357377
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:30159
    BTB; BTB/POZ domain
    pfam13465
    Location:369394
    zf-H2C2_2; Zinc-finger double domain
  3. NM_019574.3NP_062520.1  POZ (BTB) and AT hook-containing zinc finger 1 isoform 1

    See identical proteins and their annotated locations for NP_062520.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL671968
    Consensus CDS
    CCDS24356.1
    UniProtKB/TrEMBL
    A0A8C6GED8, Q9JMG9
    Related
    ENSMUSP00000050684.7, ENSMUST00000057089.13
    Conserved Domains (6) summary
    COG5189
    Location:379436
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:357377
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:30159
    BTB; BTB/POZ domain
    pfam13465
    Location:369394
    zf-H2C2_2; Zinc-finger double domain
    pfam13912
    Location:442467
    zf-C2H2_6; C2H2-type zinc finger
    pfam16637
    Location:492558
    zf-C2H2_assoc3; Putative zinc-finger between two C2H2 zinc-fingers on Patz

RNA

  1. NR_045108.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' exon and includes two additional internal exons, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, as found in variant 1.
    Source sequence(s)
    AL671968, BC043035, CJ106364
    Related
    ENSMUST00000134089.8
  2. NR_045109.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' exon, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, as found in variant 1.
    Source sequence(s)
    AK018372, BC043035, CJ106364
    Related
    ENSMUST00000101644.10

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    3239131..3259083
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)