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PRKX protein kinase X-linked [ Homo sapiens (human) ]

Gene ID: 5613, updated on 13-Mar-2020

Summary

Official Symbol
PRKXprovided by HGNC
Official Full Name
protein kinase X-linkedprovided by HGNC
Primary source
HGNC:HGNC:9441
See related
Ensembl:ENSG00000183943 MIM:300083
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PKX1
Summary
This gene encodes a serine threonine protein kinase that has similarity to the catalytic subunit of cyclic AMP dependent protein kinases. The encoded protein is developmentally regulated and may be involved in renal epithelial morphogenesis. This protein may also be involved in macrophage and granulocyte maturation. Abnormal recombination between this gene and a related pseudogene on chromosome Y is a frequent cause of sex reversal disorder in XX males and XY females. Pseudogenes of this gene are found on chromosomes X, 15 and Y. [provided by RefSeq, Feb 2010]
Expression
Broad expression in thyroid (RPKM 22.9), kidney (RPKM 7.3) and 20 other tissues See more
Orthologs

Genomic context

See PRKX in Genome Data Viewer
Location:
Xp22.33
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (3604340..3713649, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (3522384..3631675, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA, H/ACA box 48B Neighboring gene RNA, U6 small nuclear 114, pseudogene Neighboring gene RNA, U6 small nuclear 146, pseudogene Neighboring gene PRKX antisense RNA 1 Neighboring gene RPS27A pseudogene 20 Neighboring gene zinc finger protein 839 pseudogene Neighboring gene tRNA-Ile (anticodon GAT) 1-1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of protein kinase, X-linked (PRKX) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
cAMP-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cAMP-dependent protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell-substrate adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
endothelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
endothelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
epithelial tube morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
kidney morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
myeloid cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell migration IDA
Inferred from Direct Assay
more info
PubMed 
regulation of epithelial cell differentiation involved in kidney development IDA
Inferred from Direct Assay
more info
PubMed 
signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cAMP-dependent protein kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cAMP-dependent protein kinase catalytic subunit PRKX
Names
protein kinase PKX1
protein kinase X
serine/threonine-protein kinase PRKX
NP_005035.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016716.1 RefSeqGene

    Range
    4986..114295
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_005044.5NP_005035.1  cAMP-dependent protein kinase catalytic subunit PRKX

    See identical proteins and their annotated locations for NP_005035.1

    Status: REVIEWED

    Source sequence(s)
    AC007685, BC041073, BE675757, DN997580
    Consensus CDS
    CCDS14125.1
    UniProtKB/Swiss-Prot
    P51817
    UniProtKB/TrEMBL
    A0A024RBU5
    Related
    ENSP00000262848.5, ENST00000262848.6
    Conserved Domains (2) summary
    PTZ00263
    Location:39358
    PTZ00263; protein kinase A catalytic subunit; Provisional
    cd05612
    Location:47338
    STKc_PRKX_like; Catalytic domain of PRKX-like Protein Serine/Threonine Kinases

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    3604340..3713649 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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