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PKN1 protein kinase N1 [ Homo sapiens (human) ]

Gene ID: 5585, updated on 2-Oct-2018

Summary

Official Symbol
PKN1provided by HGNC
Official Full Name
protein kinase N1provided by HGNC
Primary source
HGNC:HGNC:9405
See related
Ensembl:ENSG00000123143 MIM:601032; Vega:OTTHUMG00000039611
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DBK; PKN; PAK1; PRK1; PAK-1; PRKCL1; PKN-ALPHA
Summary
The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in spleen (RPKM 39.4), fat (RPKM 30.1) and 25 other tissues See more
Orthologs

Genomic context

See PKN1 in Genome Data Viewer
Location:
19p13.12
Exon count:
24
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (14433354..14471867)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (14544166..14582679)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene adhesion G protein-coupled receptor E5 Neighboring gene DExD-box helicase 39A Neighboring gene prostaglandin E receptor 1 Neighboring gene GIPC PDZ domain containing family member 1 Neighboring gene small nuclear ribonucleoprotein polypeptide G pseudogene 15

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Application of HIV-1 Tat transmembrane transport peptide to cells induces PKN1 gene and slightly represses two genes, ZCD1 and BSG PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC46204

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
GTP-Rho binding IDA
Inferred from Direct Assay
more info
PubMed 
Rac GTPase binding IDA
Inferred from Direct Assay
more info
PubMed 
androgen receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
histone binding IDA
Inferred from Direct Assay
more info
PubMed 
histone deacetylase binding IDA
Inferred from Direct Assay
more info
PubMed 
histone kinase activity (H3-T11 specific) IDA
Inferred from Direct Assay
more info
PubMed 
nuclear receptor transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
nuclear receptor transcription coactivator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase C activity IEA
Inferred from Electronic Annotation
more info
 
protein kinase C binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity TAS
Traceable Author Statement
more info
PubMed 
protein serine/threonine kinase activity EXP
Inferred from Experiment
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
B cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
B cell homeostasis IEA
Inferred from Electronic Annotation
more info
 
activation of JUN kinase activity TAS
Traceable Author Statement
more info
PubMed 
epithelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
histone H3-T11 phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
hyperosmotic response IEA
Inferred from Electronic Annotation
more info
 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of B cell proliferation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of nucleic acid-templated transcription IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell motility IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of germinal center formation IEA
Inferred from Electronic Annotation
more info
 
regulation of immunoglobulin production IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
renal system process IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
spleen development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cleavage furrow IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
endosome IDA
Inferred from Direct Assay
more info
PubMed 
midbody IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase N1
Names
protease-activated kinase 1
protein kinase C-like 1
protein kinase C-like PKN
protein kinase C-related kinase 1
protein kinase PKN-alpha
serine-threonine kinase N
serine/threonine protein kinase N
NP_002732.3
NP_998725.1
XP_011526430.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002741.4NP_002732.3  serine/threonine-protein kinase N1 isoform 2

    See identical proteins and their annotated locations for NP_002732.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate exon at the 5' end compared to variant 1, which includes a part of the coding region. The resulting isoform (2) has a distinct and shorter N-terminus, as compared to isoform 1.
    Source sequence(s)
    AC008569
    Consensus CDS
    CCDS42513.1
    UniProtKB/Swiss-Prot
    Q16512
    Related
    ENSP00000242783.6, OTTHUMP00000037582, ENST00000242783.10
    Conserved Domains (6) summary
    cd08687
    Location:389476
    C2_PKN-like; C2 domain in Protein kinase C-like (PKN) proteins
    cd11622
    Location:4698
    HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    cd11630
    Location:121196
    HR1_PKN1_2; Second Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N1
    cd11636
    Location:205278
    HR1_PKN1_3; Third Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N1
    smart00220
    Location:615874
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05589
    Location:615939
    STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
  2. NM_213560.2NP_998725.1  serine/threonine-protein kinase N1 isoform 1

    See identical proteins and their annotated locations for NP_998725.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC008569
    Consensus CDS
    CCDS42514.1
    UniProtKB/Swiss-Prot
    Q16512
    Related
    ENSP00000343325.4, OTTHUMP00000037583, ENST00000342216.8
    Conserved Domains (6) summary
    cd08687
    Location:395482
    C2_PKN-like; C2 domain in Protein kinase C-like (PKN) proteins
    cd11622
    Location:52104
    HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    cd11630
    Location:127202
    HR1_PKN1_2; Second Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N1
    cd11636
    Location:211284
    HR1_PKN1_3; Third Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N1
    smart00220
    Location:621880
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05589
    Location:621945
    STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    14433354..14471867
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528128.1XP_011526430.1  serine/threonine-protein kinase N1 isoform X1

    Conserved Domains (6) summary
    cd08687
    Location:401488
    C2_PKN-like; C2 domain in Protein kinase C-like (PKN) proteins
    cd11622
    Location:58110
    HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
    cd11630
    Location:133208
    HR1_PKN1_2; Second Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N1
    cd11636
    Location:217290
    HR1_PKN1_3; Third Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N1
    smart00220
    Location:627886
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05589
    Location:627951
    STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
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