Format

Send to:

Choose Destination

AXL AXL receptor tyrosine kinase [ Homo sapiens (human) ]

Gene ID: 558, updated on 28-Nov-2021

Summary

Official Symbol
AXLprovided by HGNC
Official Full Name
AXL receptor tyrosine kinaseprovided by HGNC
Primary source
HGNC:HGNC:905
See related
Ensembl:ENSG00000167601 MIM:109135
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARK; UFO; JTK11; Tyro7
Summary
The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. The encoded protein acts as a host cell receptor for multiple viruses, including Marburg, Ebola and Lassa viruses and is a candidate receptor for the SARS-CoV2 virus. [provided by RefSeq, Sep 2021]
Annotation information
Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in SARS-CoV-2 infection.
Expression
Ubiquitous expression in spleen (RPKM 20.7), endometrium (RPKM 15.3) and 23 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See AXL in Genome Data Viewer
Location:
19q13.2
Exon count:
21
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (41219223..41261766)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (41725128..41767671)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 718, pseudogene Neighboring gene cytochrome P450 family 2 subfamily S member 1 Neighboring gene tRNA-Lys (anticodon TTT) 10-1 Neighboring gene heterogeneous nuclear ribonucleoprotein U like 1 Neighboring gene RNA, 7SL, cytoplasmic 34, pseudogene Neighboring gene uncharacterized LOC105372401 Neighboring gene coiled-coil domain containing 97

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 Vpr upregulates the gene expression of AXL in human monocyte-derived dendritic cells PubMed
capsid gag AXL inhibits the release of HIV-1 in terms of reduced levels of CA in virus particles and induces the accumulation of cell-associated CA PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables myosin heavy chain binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol 3-kinase binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylserine binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine kinase activity EXP
Inferred from Experiment
more info
PubMed 
enables transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables virus receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in animal organ regeneration IEA
Inferred from Electronic Annotation
more info
 
involved_in blood vessel remodeling IEA
Inferred from Electronic Annotation
more info
 
involved_in cell maturation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to extracellular stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to hydrogen peroxide IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to interferon-alpha IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
PubMed 
involved_in dendritic cell differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in erythrocyte homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in forebrain cell migration IEA
Inferred from Electronic Annotation
more info
 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in natural killer cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of dendritic cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of interferon-gamma production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of lymphocyte activation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of tumor necrosis factor production IEA
Inferred from Electronic Annotation
more info
 
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neuron migration IEA
Inferred from Electronic Annotation
more info
 
involved_in neutrophil clearance IEA
Inferred from Electronic Annotation
more info
 
involved_in ovulation cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in phagocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phagocytosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in platelet activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cytokine-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of natural killer cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of pinocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein kinase B signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of viral life cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein kinase B signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in secretion by cell IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction TAS
Traceable Author Statement
more info
PubMed 
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in substrate adhesion-dependent cell spreading IEA
Inferred from Electronic Annotation
more info
 
involved_in transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in vagina development IEA
Inferred from Electronic Annotation
more info
 
involved_in vascular endothelial growth factor receptor signaling pathway TAS
Traceable Author Statement
more info
 
involved_in viral entry into host cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
 
located_in cell surface HDA PubMed 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular exosome HDA PubMed 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
located_in host cell surface IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
tyrosine-protein kinase receptor UFO
Names
AXL oncogene
AXL transforming sequence/gene
NP_001265528.1
NP_001690.2
NP_068713.2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278599.2NP_001265528.1  tyrosine-protein kinase receptor UFO isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks four alternate exons in the 5' coding region and initiates translation at a downstream AUG, compared to variant 1. It encodes isoform 3 which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AI300772, AI309979, AK309139, CA437238, X66029
    Consensus CDS
    CCDS62677.1
    UniProtKB/TrEMBL
    M0R0W6
    Related
    ENSP00000471497.1, ENST00000593513.1
    Conserved Domains (4) summary
    smart00221
    Location:270535
    STYKc; Protein kinase; unclassified specificity
    cd00063
    Location:2060
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05075
    Location:267543
    PTKc_Axl; Catalytic domain of the Protein Tyrosine Kinase, Axl
    pfam00041
    Location:67150
    fn3; Fibronectin type III domain
  2. NM_001699.6NP_001690.2  tyrosine-protein kinase receptor UFO isoform 2 precursor

    See identical proteins and their annotated locations for NP_001690.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. It encodes isoform 2, which lacks an internal segment and is shorter than isoform 1.
    Source sequence(s)
    AI300772, AI309979, AK309139, AL556721, BC032229, CA437238, HY045208, M76125, X66029
    Consensus CDS
    CCDS12574.1
    UniProtKB/Swiss-Prot
    P30530
    Related
    ENSP00000351995.2, ENST00000359092.7
    Conserved Domains (7) summary
    cd00096
    Location:53126
    Ig; Immunoglobulin domain
    cd05749
    Location:141222
    Ig2_Tyro3_like; Second immunoglobulin (Ig)-like domain of Axl/Tyro3 receptor tyrosine kinases (RTKs)
    smart00221
    Location:529794
    STYKc; Protein kinase; unclassified specificity
    smart00410
    Location:145223
    IG_like; Immunoglobulin like
    cd00063
    Location:225328
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05075
    Location:526802
    PTKc_Axl; Catalytic domain of the Protein Tyrosine Kinase, Axl
    pfam00041
    Location:335418
    fn3; Fibronectin type III domain
  3. NM_021913.5NP_068713.2  tyrosine-protein kinase receptor UFO isoform 1 precursor

    See identical proteins and their annotated locations for NP_068713.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AI300772, AI309979, AK309139, AL556721, BC032229, CA437238, HY045208, X66029
    Consensus CDS
    CCDS12575.1
    UniProtKB/Swiss-Prot
    P30530
    Related
    ENSP00000301178.3, ENST00000301178.9
    Conserved Domains (5) summary
    cd05749
    Location:141222
    Ig2_Axl_Tyro3_like; Second immunoglobulin (Ig)-like domain of Axl/Tyro3 family receptor tyrosine kinases (RTKs)
    cd00063
    Location:225328
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05075
    Location:535811
    PTKc_Axl; Catalytic domain of the Protein Tyrosine Kinase, Axl
    pfam00041
    Location:335418
    fn3; Fibronectin type III domain
    cd00096
    Location:53119
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    41219223..41261766
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center