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Axl AXL receptor tyrosine kinase [ Mus musculus (house mouse) ]

Gene ID: 26362, updated on 2-Aug-2021

Summary

Official Symbol
Axlprovided by MGI
Official Full Name
AXL receptor tyrosine kinaseprovided by MGI
Primary source
MGI:MGI:1347244
See related
Ensembl:ENSMUSG00000002602
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A; Uf; Ark; Tyr; Ufo; Tyro7; AI323647
Expression
Broad expression in ovary adult (RPKM 53.4), mammary gland adult (RPKM 42.5) and 28 other tissues See more
Orthologs
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Genomic context

See Axl in Genome Data Viewer
Location:
7 A3; 7 14.02 cM
Exon count:
20
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (25455925..25488502, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (25756500..25788924, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (26542292..26573560, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 97 Neighboring gene heterogeneous nuclear ribonucleoprotein U-like 1 Neighboring gene predicted gene, 29763 Neighboring gene cytochrome P450, family 2, subfamily s, polypeptide 1 Neighboring gene 60S ribosomal protein L37a pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables myosin heavy chain binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol 3-kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidylserine binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables virus receptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic cell clearance IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within apoptotic cell clearance IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within blood vessel remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cellular response to extracellular stimulus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to interferon-alpha ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within enzyme linked receptor protein signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within erythrocyte homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within erythrocyte homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within forebrain cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in natural killer cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within natural killer cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of cytokine production IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of dendritic cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of interferon-gamma production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of lymphocyte activation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of neuron apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of tumor necrosis factor production IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within neuron migration IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within neutrophil clearance IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within ovulation cycle IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in phagocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within phagocytosis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in phagocytosis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in platelet activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within platelet activation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cytokine-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of natural killer cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of pinocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein kinase B signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of protein kinase B signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of viral life cycle ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein kinase B signaling IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within protein kinase B signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within secretion by cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within spermatogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within substrate adhesion-dependent cell spreading IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within vagina development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in viral entry into host cell ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in host cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
tyrosine-protein kinase receptor UFO
Names
adhesion-related kinase
ufo oncogene homolog
NP_001177903.1
NP_001177904.1
NP_033491.2
XP_006540052.1
XP_006540054.1
XP_006540055.1
XP_006540056.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001190974.1NP_001177903.1  tyrosine-protein kinase receptor UFO isoform 2 precursor

    See identical proteins and their annotated locations for NP_001177903.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter, compared to isoform 1.
    Source sequence(s)
    AC119211, AC162614, AK033237, BC058230
    Consensus CDS
    CCDS57528.1
    UniProtKB/TrEMBL
    Q6PE80, Q8CCF8
    Related
    ENSMUSP00000083110.5, ENSMUST00000085948.11
    Conserved Domains (5) summary
    cd00063
    Location:219322
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05075
    Location:520796
    PTKc_Axl; Catalytic domain of the Protein Tyrosine Kinase, Axl
    cd00096
    Location:47114
    Ig; Immunoglobulin domain
    pfam00041
    Location:329411
    fn3; Fibronectin type III domain
    cl11960
    Location:135216
    Ig; Immunoglobulin domain
  2. NM_001190975.1NP_001177904.1  tyrosine-protein kinase receptor UFO isoform 3 precursor

    See identical proteins and their annotated locations for NP_001177904.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate exons, resulting in the loss of an in-frame segment in the central coding region, compared to variant 1. The resulting protein (isoform 3) is shorter, compared to isoform 1.
    Source sequence(s)
    AC119211, AC162614
    Conserved Domains (4) summary
    cd00063
    Location:219322
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05075
    Location:432708
    PTKc_Axl; Catalytic domain of the Protein Tyrosine Kinase, Axl
    cd00096
    Location:47114
    Ig; Immunoglobulin domain
    cl11960
    Location:135216
    Ig; Immunoglobulin domain
  3. NM_009465.4NP_033491.2  tyrosine-protein kinase receptor UFO isoform 1 precursor

    See identical proteins and their annotated locations for NP_033491.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC119211, AC162614, AK033237, BC050914
    Consensus CDS
    CCDS20996.1
    UniProtKB/Swiss-Prot
    Q00993
    UniProtKB/TrEMBL
    Q8CCF8
    Related
    ENSMUSP00000002677.5, ENSMUST00000002677.11
    Conserved Domains (5) summary
    cd00063
    Location:219322
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05075
    Location:529805
    PTKc_Axl; Catalytic domain of the Protein Tyrosine Kinase, Axl
    cd00096
    Location:47114
    Ig; Immunoglobulin domain
    pfam00041
    Location:329411
    fn3; Fibronectin type III domain
    cl11960
    Location:135216
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    25455925..25488502 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539991.5XP_006540054.1  tyrosine-protein kinase receptor UFO isoform X2

    See identical proteins and their annotated locations for XP_006540054.1

    UniProtKB/TrEMBL
    Q6PE80
    Conserved Domains (5) summary
    cd00063
    Location:219322
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05075
    Location:520796
    PTKc_Axl; Catalytic domain of the Protein Tyrosine Kinase, Axl
    cd00096
    Location:47114
    Ig; Immunoglobulin domain
    pfam00041
    Location:329411
    fn3; Fibronectin type III domain
    cl11960
    Location:135216
    Ig; Immunoglobulin domain
  2. XM_006539989.5XP_006540052.1  tyrosine-protein kinase receptor UFO isoform X1

    See identical proteins and their annotated locations for XP_006540052.1

    UniProtKB/Swiss-Prot
    Q00993
    Conserved Domains (5) summary
    cd00063
    Location:219322
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05075
    Location:529805
    PTKc_Axl; Catalytic domain of the Protein Tyrosine Kinase, Axl
    cd00096
    Location:47114
    Ig; Immunoglobulin domain
    pfam00041
    Location:329411
    fn3; Fibronectin type III domain
    cl11960
    Location:135216
    Ig; Immunoglobulin domain
  3. XM_006539992.3XP_006540055.1  tyrosine-protein kinase receptor UFO isoform X3

    See identical proteins and their annotated locations for XP_006540055.1

    Conserved Domains (4) summary
    cd00063
    Location:219322
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05075
    Location:432708
    PTKc_Axl; Catalytic domain of the Protein Tyrosine Kinase, Axl
    cd00096
    Location:47114
    Ig; Immunoglobulin domain
    cl11960
    Location:135216
    Ig; Immunoglobulin domain
  4. XM_006539993.4XP_006540056.1  tyrosine-protein kinase receptor UFO isoform X4

    Conserved Domains (4) summary
    cd00063
    Location:219322
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05075
    Location:423699
    PTKc_Axl; Catalytic domain of the Protein Tyrosine Kinase, Axl
    cd00096
    Location:47114
    Ig; Immunoglobulin domain
    cl11960
    Location:135216
    Ig; Immunoglobulin domain
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