Axl AXL receptor tyrosine kinase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Axlprovided by MGI
Official Full Name: AXL receptor tyrosine kinaseprovided by MGI
Primary source: MGI:MGI:1347244
See related: Ensembl:ENSMUSG00000002602 AllianceGenome:MGI:1347244
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ark; Ufo; Tyro7
Summary: Predicted to enable several functions, including phosphatidylinositol 3-kinase binding activity; phosphatidylserine binding activity; and virus receptor activity. Involved in negative regulation of apoptotic process and positive regulation of protein kinase B signaling. Acts upstream of or within several processes, including animal organ development; myeloid cell homeostasis; and negative regulation of tumor necrosis factor production. Predicted to be located in several cellular components, including actin cytoskeleton; cell surface; and host cell surface. Predicted to be part of receptor complex. Predicted to be integral component of plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and visual system. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human AXL (AXL receptor tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in ovary adult (RPKM 53.4), mammary gland adult (RPKM 42.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 A3; 7 14.02 cM

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (25455925..25488502, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (25756500..25788924, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Role of miR-944/MMP10/AXL- axis in lymph node metastasis in tongue cancer.
Title: Role of miR-944/MMP10/AXL- axis in lymph node metastasis in tongue cancer.
Axl receptor induces efferocytosis, dampens M1 macrophage responses and promotes heart pathology in Trypanosoma cruzi infection.
Title: Axl receptor induces efferocytosis, dampens M1 macrophage responses and promotes heart pathology in Trypanosoma cruzi infection.
Role of Axl in target organ inflammation and damage due to hypertensive aortic remodeling.
Title: Role of Axl in target organ inflammation and damage due to hypertensive aortic remodeling.
The TAM receptor tyrosine kinases Axl and Mer drive the maintenance of highly phagocytic macrophages.
Title: The TAM receptor tyrosine kinases Axl and Mer drive the maintenance of highly phagocytic macrophages.
Decreased expression of airway epithelial Axl is associated with eosinophilic inflammation in severe asthma.
Title: Decreased expression of airway epithelial Axl is associated with eosinophilic inflammation in severe asthma.
Activated AXL Protects Against Hepatic Ischemia-reperfusion Injury by Upregulating SOCS-1 Expression.
Title: Activated AXL Protects Against Hepatic Ischemia-reperfusion Injury by Upregulating SOCS-1 Expression.
Targeting Axl favors an antitumorigenic microenvironment that enhances immunotherapy responses by decreasing Hif-1alpha levels.
Title: Targeting Axl favors an antitumorigenic microenvironment that enhances immunotherapy responses by decreasing Hif-1α levels.
AXL kinase-mediated astrocytic phagocytosis modulates outcomes of traumatic brain injury.
Title: AXL kinase-mediated astrocytic phagocytosis modulates outcomes of traumatic brain injury.
TAM kinase signaling is indispensable for proper skeletal muscle regeneration in mice.
Title: TAM kinase signaling is indispensable for proper skeletal muscle regeneration in mice.
Macrophage AXL receptor tyrosine kinase inflames the heart after reperfused myocardial infarction.
Title: Macrophage AXL receptor tyrosine kinase inflames the heart after reperfused myocardial infarction.

Submit: New GeneRIF Correction See all GeneRIFs (88)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI323647 (e-PCR)
- UniSTS:179537

X63535 (e-PCR)
- UniSTS:163412

Axl (e-PCR), detects polymorphism
- UniSTS:496039

Axl (e-PCR), detects polymorphism
- UniSTS:256960

Axl (e-PCR), detects polymorphism
- UniSTS:256997

Homology

Homologs of the Axl gene: The Axl gene is conserved in human, chimpanzee, dog, cow, rat, and frog.
Orthologs from Annotation Pipeline: 387 organisms have orthologs with human gene Axl
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables myosin heavy chain binding	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol 3-kinase binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylserine binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables transmembrane receptor protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables virus receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic cell clearance	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within apoptotic cell clearance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within blood vessel remodeling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within cellular response to extracellular stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to hydrogen peroxide	ISO Inferred from Sequence Orthology more info
involved_in cellular response to interferon-alpha	ISO Inferred from Sequence Orthology more info
involved_in cellular response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within enzyme-linked receptor protein signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within erythrocyte homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within erythrocyte homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within establishment of localization in cell	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within establishment of localization in cell	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within forebrain cell migration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
acts_upstream_of lymphocyte activation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of macrophage cytokine production	IGI Inferred from Genetic Interaction more info	PubMed
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in natural killer cell differentiation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within natural killer cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within negative regulation of apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of cytokine production	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of dendritic cell apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of lymphocyte activation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of macrophage cytokine production	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of neuron apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of tumor necrosis factor production	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of neuron apoptotic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neuron migration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neutrophil clearance	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within ovulation cycle	IGI Inferred from Genetic Interaction more info	PubMed
involved_in phagocytosis	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within phagocytosis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in phagocytosis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in platelet activation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within platelet activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytokine-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of kinase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in positive regulation of natural killer cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of pinocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein kinase B signaling	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in positive regulation of protein kinase B signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of viral life cycle	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein kinase B signaling	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within protein kinase B signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within secretion by cell	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spermatogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within substrate adhesion-dependent cell spreading	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of tumor necrosis factor production	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within vagina development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in viral entry into host cell	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed

General protein information

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Preferred Names: tyrosine-protein kinase receptor UFO

Names: adhesion-related kinase; ufo oncogene homolog

NP_001177903.1

EC 2.7.10.1

NP_001177904.1

EC 2.7.10.1

NP_033491.2

EC 2.7.10.1

XP_006540052.1

EC 2.7.10.1

XP_006540054.1

EC 2.7.10.1

XP_006540055.1

EC 2.7.10.1

XP_006540056.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001190974.1 → NP_001177903.1 tyrosine-protein kinase receptor UFO isoform 2 precursor

See identical proteins and their annotated locations for NP_001177903.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter, compared to isoform 1.

Source sequence(s)

AC119211, AC162614, AK033237, BC058230

Consensus CDS

CCDS57528.1

UniProtKB/TrEMBL

Q6PE80, Q8CCF8

Related

ENSMUSP00000083110.5, ENSMUST00000085948.11

Conserved Domains (5) summary

cd00063
Location:219 → 322

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd05075
Location:520 → 796

PTKc_Axl; Catalytic domain of the Protein Tyrosine Kinase, Axl

cd00096
Location:47 → 114

Ig; Immunoglobulin domain

pfam00041
Location:329 → 411

fn3; Fibronectin type III domain

cl11960
Location:135 → 216

Ig; Immunoglobulin domain
NM_001190975.1 → NP_001177904.1 tyrosine-protein kinase receptor UFO isoform 3 precursor

See identical proteins and their annotated locations for NP_001177904.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks two alternate exons, resulting in the loss of an in-frame segment in the central coding region, compared to variant 1. The resulting protein (isoform 3) is shorter, compared to isoform 1.

Source sequence(s)

AC119211, AC162614

Conserved Domains (4) summary

cd00063
Location:219 → 322

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd05075
Location:432 → 708

PTKc_Axl; Catalytic domain of the Protein Tyrosine Kinase, Axl

cd00096
Location:47 → 114

Ig; Immunoglobulin domain

cl11960
Location:135 → 216

Ig; Immunoglobulin domain
NM_009465.4 → NP_033491.2 tyrosine-protein kinase receptor UFO isoform 1 precursor

See identical proteins and their annotated locations for NP_033491.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC119211, AC162614, AK033237, BC050914

Consensus CDS

CCDS20996.1

UniProtKB/Swiss-Prot

Q00993, Q80YQ3

UniProtKB/TrEMBL

Q8CCF8

Related

ENSMUSP00000002677.5, ENSMUST00000002677.11

Conserved Domains (5) summary

cd00063
Location:219 → 322

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd05075
Location:529 → 805

PTKc_Axl; Catalytic domain of the Protein Tyrosine Kinase, Axl

cd00096
Location:47 → 114

Ig; Immunoglobulin domain

pfam00041
Location:329 → 411

fn3; Fibronectin type III domain

cl11960
Location:135 → 216

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

25455925..25488502 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006539991.5 → XP_006540054.1 tyrosine-protein kinase receptor UFO isoform X2

See identical proteins and their annotated locations for XP_006540054.1

UniProtKB/TrEMBL

Q6PE80

Conserved Domains (5) summary

cd00063
Location:219 → 322

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd05075
Location:520 → 796

PTKc_Axl; Catalytic domain of the Protein Tyrosine Kinase, Axl

cd00096
Location:47 → 114

Ig; Immunoglobulin domain

pfam00041
Location:329 → 411

fn3; Fibronectin type III domain

cl11960
Location:135 → 216

Ig; Immunoglobulin domain
XM_006539989.5 → XP_006540052.1 tyrosine-protein kinase receptor UFO isoform X1

See identical proteins and their annotated locations for XP_006540052.1

UniProtKB/Swiss-Prot

Q00993, Q80YQ3

Conserved Domains (5) summary

cd00063
Location:219 → 322

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd05075
Location:529 → 805

PTKc_Axl; Catalytic domain of the Protein Tyrosine Kinase, Axl

cd00096
Location:47 → 114

Ig; Immunoglobulin domain

pfam00041
Location:329 → 411

fn3; Fibronectin type III domain

cl11960
Location:135 → 216

Ig; Immunoglobulin domain
XM_006539992.3 → XP_006540055.1 tyrosine-protein kinase receptor UFO isoform X3

See identical proteins and their annotated locations for XP_006540055.1

Conserved Domains (4) summary

cd00063
Location:219 → 322

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd05075
Location:432 → 708

PTKc_Axl; Catalytic domain of the Protein Tyrosine Kinase, Axl

cd00096
Location:47 → 114

Ig; Immunoglobulin domain

cl11960
Location:135 → 216

Ig; Immunoglobulin domain
XM_006539993.4 → XP_006540056.1 tyrosine-protein kinase receptor UFO isoform X4

Conserved Domains (4) summary

cd00063
Location:219 → 322

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd05075
Location:423 → 699

PTKc_Axl; Catalytic domain of the Protein Tyrosine Kinase, Axl

cd00096
Location:47 → 114

Ig; Immunoglobulin domain

cl11960
Location:135 → 216

Ig; Immunoglobulin domain