Format

Send to:

Choose Destination

ZNF701 zinc finger protein 701 [ Homo sapiens (human) ]

Gene ID: 55762, updated on 10-Oct-2019

Summary

Official Symbol
ZNF701provided by HGNC
Official Full Name
zinc finger protein 701provided by HGNC
Primary source
HGNC:HGNC:25597
See related
Ensembl:ENSG00000167562
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in thyroid (RPKM 1.6), placenta (RPKM 1.6) and 25 other tissues See more
Orthologs

Genomic context

See ZNF701 in Genome Data Viewer
Location:
19q13.41
Exon count:
12
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (52570273..52627269)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (53073526..53090427)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 347 pseudogene Neighboring gene zinc finger protein 578 Neighboring gene zinc finger protein 808 Neighboring gene ribosomal protein L39 pseudogene 34 Neighboring gene zinc finger protein 137, pseudogene Neighboring gene zinc finger protein 83 Neighboring gene zinc finger protein 611 Neighboring gene uncharacterized LOC105372452 Neighboring gene uncharacterized LOC105372451

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of zinc finger protein 701 (ZNF701) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10891

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001172655.1NP_001166126.1  zinc finger protein 701 isoform 1

    See identical proteins and their annotated locations for NP_001166126.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC022150, BC067346
    Consensus CDS
    CCDS54311.1
    UniProtKB/Swiss-Prot
    Q9NV72
    UniProtKB/TrEMBL
    Q6NWZ7
    Related
    ENSP00000444339.1, ENST00000540331.1
    Conserved Domains (5) summary
    smart00349
    Location:74114
    KRAB; krueppel associated box
    COG5048
    Location:390527
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:338358
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:74113
    KRAB; KRAB box
    pfam13465
    Location:406431
    zf-H2C2_2; Zinc-finger double domain
  2. NM_018260.2NP_060730.2  zinc finger protein 701 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter and 5' UTR, lacks an alternate exon, and uses a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC022150
    Consensus CDS
    CCDS33092.1
    UniProtKB/Swiss-Prot
    Q9NV72
    Related
    ENSP00000375662.2, ENST00000391785.7
    Conserved Domains (5) summary
    smart00349
    Location:848
    KRAB; krueppel associated box
    COG5048
    Location:324461
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:272292
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:340365
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    52570273..52627269
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527092.1XP_011525394.1  zinc finger protein 701 isoform X1

    See identical proteins and their annotated locations for XP_011525394.1

    UniProtKB/Swiss-Prot
    Q9NV72
    Related
    ENSP00000301093.2, ENST00000301093.6
    Conserved Domains (5) summary
    smart00349
    Location:74114
    KRAB; krueppel associated box
    COG5048
    Location:390527
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:338358
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:74113
    KRAB; KRAB box
    pfam13465
    Location:406431
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. XR_001753718.2 RNA Sequence

  2. XR_001753716.2 RNA Sequence

  3. XR_001753717.2 RNA Sequence

  4. XR_001753715.2 RNA Sequence

Support Center