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PKIB cAMP-dependent protein kinase inhibitor beta [ Homo sapiens (human) ]

Gene ID: 5570, updated on 24-Nov-2020

Summary

Official Symbol
PKIBprovided by HGNC
Official Full Name
cAMP-dependent protein kinase inhibitor betaprovided by HGNC
Primary source
HGNC:HGNC:9018
See related
Ensembl:ENSG00000135549 MIM:606914
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PRKACN2
Summary
This gene encodes a member of the cAMP-dependent protein kinase inhibitor family. The encoded protein may play a role in the protein kinase A (PKA) pathway by interacting with the catalytic subunit of PKA, and overexpression of this gene may play a role in prostate cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Expression
Biased expression in colon (RPKM 18.8), placenta (RPKM 15.5) and 10 other tissues See more
Orthologs

Genomic context

See PKIB in Genome Data Viewer
Location:
6q22.31
Exon count:
16
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (122471921..122726373)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (122793062..123047518)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene heat shock transcription factor 2 Neighboring gene serine incorporator 1 Neighboring gene uncharacterized LOC112267966 Neighboring gene RNA, 7SL, cytoplasmic 564, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of protein kinase (cAMP-dependent, catalytic) inhibitor beta (PKIB) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ23817, DKFZp781K1114

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cAMP-dependent protein kinase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
cAMP-dependent protein kinase inhibitor beta
Names
PKI-beta
cAMP-dependent protein kinase inhibitor 2
protein kinase (cAMP-dependent, catalytic) inhibitor beta

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270393.2NP_001257322.1  cAMP-dependent protein kinase inhibitor beta isoform 1

    See identical proteins and their annotated locations for NP_001257322.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3 and 4 encode the same isoform (1).
    Source sequence(s)
    AL512283, BG507119, BM802552, BM969901, BU753807
    Consensus CDS
    CCDS5126.1
    UniProtKB/Swiss-Prot
    Q9C010
    Conserved Domains (1) summary
    pfam02827
    Location:977
    PKI; cAMP-dependent protein kinase inhibitor
  2. NM_001270394.2NP_001257323.1  cAMP-dependent protein kinase inhibitor beta isoform 2

    See identical proteins and their annotated locations for NP_001257323.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. Variants 5 and 6 encode the same isoform (2), which is longer and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AL512283, BC036011, BG507119, BM802552, BU753807
    Consensus CDS
    CCDS59033.1
    UniProtKB/Swiss-Prot
    Q9C010
    Related
    ENSP00000480824.1, ENST00000615438.4
    Conserved Domains (1) summary
    pfam02827
    Location:1684
    PKI; cAMP-dependent protein kinase inhibitor
  3. NM_001270395.2NP_001257324.1  cAMP-dependent protein kinase inhibitor beta isoform 2

    See identical proteins and their annotated locations for NP_001257324.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. Variants 5 and 6 encode the same isoform (2), which is longer and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AL512283, BC036011, BP262756, BU753807
    Consensus CDS
    CCDS59033.1
    UniProtKB/Swiss-Prot
    Q9C010
    Related
    ENSP00000258014.3, ENST00000258014.3
    Conserved Domains (1) summary
    pfam02827
    Location:1684
    PKI; cAMP-dependent protein kinase inhibitor
  4. NM_032471.6NP_115860.1  cAMP-dependent protein kinase inhibitor beta isoform 1

    See identical proteins and their annotated locations for NP_115860.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3 and 4 encode the same isoform (1).
    Source sequence(s)
    AL512283, BC036011, BU753807
    Consensus CDS
    CCDS5126.1
    UniProtKB/Swiss-Prot
    Q9C010
    Related
    ENSP00000376280.1, ENST00000392490.5
    Conserved Domains (1) summary
    pfam02827
    Location:977
    PKI; cAMP-dependent protein kinase inhibitor
  5. NM_181794.3NP_861459.1  cAMP-dependent protein kinase inhibitor beta isoform 1

    See identical proteins and their annotated locations for NP_861459.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3 and 4 encode the same isoform (1).
    Source sequence(s)
    AJ420562, AL512283, BG507119, BU753807
    Consensus CDS
    CCDS5126.1
    UniProtKB/Swiss-Prot
    Q9C010
    Related
    ENSP00000376281.1, ENST00000392491.6
    Conserved Domains (1) summary
    pfam02827
    Location:977
    PKI; cAMP-dependent protein kinase inhibitor
  6. NM_181795.3NP_861460.1  cAMP-dependent protein kinase inhibitor beta isoform 1

    See identical proteins and their annotated locations for NP_861460.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the shorter isoform (1). Variants 1, 2, 3 and 4 encode the same isoform.
    Source sequence(s)
    AK315151, AL512283, BP260889, BU753807
    Consensus CDS
    CCDS5126.1
    UniProtKB/Swiss-Prot
    Q9C010
    Related
    ENSP00000357437.2, ENST00000368452.7
    Conserved Domains (1) summary
    pfam02827
    Location:977
    PKI; cAMP-dependent protein kinase inhibitor

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    122471921..122726373
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011535931.3XP_011534233.1  cAMP-dependent protein kinase inhibitor beta isoform X1

    See identical proteins and their annotated locations for XP_011534233.1

    UniProtKB/Swiss-Prot
    Q9C010
    Conserved Domains (1) summary
    pfam02827
    Location:1684
    PKI; cAMP-dependent protein kinase inhibitor
  2. XM_011535933.3XP_011534235.1  cAMP-dependent protein kinase inhibitor beta isoform X1

    See identical proteins and their annotated locations for XP_011534235.1

    UniProtKB/Swiss-Prot
    Q9C010
    Conserved Domains (1) summary
    pfam02827
    Location:1684
    PKI; cAMP-dependent protein kinase inhibitor
  3. XM_011535930.3XP_011534232.1  cAMP-dependent protein kinase inhibitor beta isoform X1

    See identical proteins and their annotated locations for XP_011534232.1

    UniProtKB/Swiss-Prot
    Q9C010
    Conserved Domains (1) summary
    pfam02827
    Location:1684
    PKI; cAMP-dependent protein kinase inhibitor
  4. XM_011535932.3XP_011534234.1  cAMP-dependent protein kinase inhibitor beta isoform X1

    See identical proteins and their annotated locations for XP_011534234.1

    UniProtKB/Swiss-Prot
    Q9C010
    Conserved Domains (1) summary
    pfam02827
    Location:1684
    PKI; cAMP-dependent protein kinase inhibitor
  5. XM_011535935.2XP_011534237.1  cAMP-dependent protein kinase inhibitor beta isoform X2

    See identical proteins and their annotated locations for XP_011534237.1

    UniProtKB/Swiss-Prot
    Q9C010
    Conserved Domains (1) summary
    pfam02827
    Location:977
    PKI; cAMP-dependent protein kinase inhibitor
  6. XM_011535936.1XP_011534238.1  cAMP-dependent protein kinase inhibitor beta isoform X2

    See identical proteins and their annotated locations for XP_011534238.1

    UniProtKB/Swiss-Prot
    Q9C010
    Conserved Domains (1) summary
    pfam02827
    Location:977
    PKI; cAMP-dependent protein kinase inhibitor
  7. XM_011535937.2XP_011534239.1  cAMP-dependent protein kinase inhibitor beta isoform X2

    See identical proteins and their annotated locations for XP_011534239.1

    UniProtKB/Swiss-Prot
    Q9C010
    Related
    ENSP00000346227.2, ENST00000354275.2
    Conserved Domains (1) summary
    pfam02827
    Location:977
    PKI; cAMP-dependent protein kinase inhibitor
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