U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

TLR8 toll like receptor 8 [ Ovis aries (sheep) ]

Gene ID: 554259, updated on 6-Jun-2024

Summary

Go to the top of the page Help
Gene symbol
TLR8
Gene description
toll like receptor 8
See related
EnsemblRapid:ENSOARG00020025004
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Ovis aries
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See TLR8 in Genome Data Viewer
Location:
chromosome: X
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current ARS-UI_Ramb_v3.0 (GCF_016772045.2) X NC_056080.1 (10973790..10991864)

Chromosome X - NC_056080.1Genomic Context describing neighboring genes Neighboring gene phosphoribosyl pyrophosphate synthetase 2 Neighboring gene toll like receptor 7 Neighboring gene thymosin beta 4 X-linked Neighboring gene uncharacterized LOC121818220

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_056080.1 Chromosome X Reference ARS-UI_Ramb_v3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Characterization of ovine TLR7 and TLR8 protein coding regions, detection of mutations and Maedi Visna virus infection. Mikula I, et al. Vet Immunol Immunopathol, 2010 Nov 15. PMID 20638136
  2. The double-stranded RNA bluetongue virus induces type I interferon in plasmacytoid dendritic cells via a MYD88-dependent TLR7/8-independent signaling pathway. Ruscanu S, et al. J Virol, 2012 May. PMID 22438548, Free PMC Article
  3. Molecular cloning and characterization of Toll-like receptors 1-10 in sheep. Chang JS, et al. Vet Immunol Immunopathol, 2009 Jan 15. PMID 19004506
  4. Differential expression of pattern recognition receptors in sheep tissues and leukocyte subsets. Nalubamba KS, et al. Vet Immunol Immunopathol, 2007 Aug 15. PMID 17604125
  5. Identification and expression of Toll-like receptors 1-10 in selected bovine and ovine tissues. Menzies M, et al. Vet Immunol Immunopathol, 2006 Jan 15. PMID 16095720

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Bluetongue virus induces IFN-alpha/beta in plasmacytoid dendritic cells via a MYD88-dependent TLR7/8-independent signaling pathway.
    Title: The double-stranded RNA bluetongue virus induces type I interferon in plasmacytoid dendritic cells via a MYD88-dependent TLR7/8-independent signaling pathway.
  2. Both mutations in TLR8, Asn165Lys (P-1.0) and Tyr349His (P-0.700), were present in extra LRR (leucine rich repeat) region. Mutations in TLR8 may play an important role as predisposition factor for Maedi Visna infection.
    Title: Characterization of ovine TLR7 and TLR8 protein coding regions, detection of mutations and Maedi Visna virus infection.
Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables pattern recognition receptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in canonical NF-kappaB signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in defense response to virus IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of interleukin-6 production IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in toll-like receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
toll-like receptor 8

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135929.1 → NP_001129401.1  toll-like receptor 8 precursor

    See identical proteins and their annotated locations for NP_001129401.1

    Status: PROVISIONAL

    Source sequence(s)
    AM981306
    UniProtKB/TrEMBL
    A0A6P9FQH3, B5DC93, C3W4W8, F1APT3
    Related
    ENSOARP00020032455.2, ENSOART00020039180.2
    Conserved Domains (5) summary
    smart00082
    Location:764 → 810
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:872 → 1008
    TIR; Toll - interleukin 1 - resistance
    cd00116
    Location:57 → 341
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:62 → 85
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:631 → 692
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_016772045.2-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UI_Ramb_v3.0 Primary Assembly

Genomic

  1. NC_056080.1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Range
    10973790..10991864
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_060407231.1 → XP_060263214.1  toll-like receptor 8 isoform X1

    UniProtKB/TrEMBL
    C3W4W8

  2. XM_060407229.1 → XP_060263212.1  toll-like receptor 8 isoform X1

    UniProtKB/TrEMBL
    C3W4W8

  3. XM_060407230.1 → XP_060263213.1  toll-like receptor 8 isoform X1

    UniProtKB/TrEMBL
    C3W4W8

  4. XM_060407228.1 → XP_060263211.1  toll-like receptor 8 isoform X1

    UniProtKB/TrEMBL
    C3W4W8

  5. XM_060407227.1 → XP_060263210.1  toll-like receptor 8 isoform X1

    UniProtKB/TrEMBL
    C3W4W8

  6. XM_042241559.2 → XP_042097493.1  toll-like receptor 8 isoform X2

    UniProtKB/TrEMBL
    A0A6P3TAK9, C3W4W8
    Conserved Domains (5) summary
    TIGR00864
    Location:734 → 817
    PCC; polycystin cation channel protein
    smart00255
    Location:872 → 1008
    TIR; Toll - interleukin 1 - resistance
    PLN00113
    Location:62 → 587
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00033
    Location:62 → 85
    LRR_RI; leucine-rich repeat [structural motif]
    cd21340
    Location:627 → 766
    PPP1R42; protein phosphatase 1 regulatory subunit 42
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.