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Tlr8 toll-like receptor 8 [ Mus musculus (house mouse) ]

Gene ID: 170744, updated on 18-Apr-2024

Summary

Official Symbol
Tlr8provided by MGI
Official Full Name
toll-like receptor 8provided by MGI
Primary source
MGI:MGI:2176887
See related
Ensembl:ENSMUSG00000040522 AllianceGenome:MGI:2176887
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable identical protein binding activity; nucleic acid binding activity; and pattern recognition receptor activity. Acts upstream of or within regulation of protein phosphorylation. Predicted to be located in external side of plasma membrane. Predicted to be active in plasma membrane. Is expressed in brain and liver. Orthologous to human TLR8 (toll like receptor 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

Location:
X F5; X 78.29 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (166024119..166047325, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (167241123..167264329, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 39549 Neighboring gene STARR-seq mESC enhancer starr_48267 Neighboring gene thymosin, beta 4, X chromosome Neighboring gene STARR-seq mESC enhancer starr_48268 Neighboring gene STARR-seq mESC enhancer starr_48270 Neighboring gene toll-like receptor 7 Neighboring gene STARR-positive B cell enhancer mm9_chrX:163766615-163766916 Neighboring gene STARR-seq mESC enhancer starr_48272 Neighboring gene STARR-seq mESC enhancer starr_48273 Neighboring gene STARR-seq mESC enhancer starr_48274 Neighboring gene phosphoribosyl pyrophosphate synthetase 2 Neighboring gene predicted gene 15239 Neighboring gene predicted gene, 26368

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables double-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables pattern recognition receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables single-stranded RNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in defense response to virus IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in defense response to virus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within inflammatory response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of interleukin-12 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of innate immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interferon-alpha production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interferon-beta production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-1 beta production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-6 production IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-8 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of type II interferon production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of protein phosphorylation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in response to virus ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in toll-like receptor 8 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in toll-like receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001313760.1NP_001300689.1  toll-like receptor 8 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' coding region and uses a downstream start codon compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AL731735, BC132054, BY210507
    UniProtKB/Swiss-Prot
    P58682
    Conserved Domains (5) summary
    PRK15370
    Location:47231
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    smart00255
    Location:8681004
    TIR; Toll - interleukin 1 - resistance
    PLN00113
    Location:141717
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00033
    Location:6285
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:701762
    LRR_8; Leucine rich repeat
  2. NM_001313761.1NP_001300690.1  toll-like receptor 8 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon in the 5' coding region and an alternate segment in the 3' end compared to variant 1. The transcript uses a downstream start codon compared to variant 1, resulting in an isoform (3) that is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AL731735, BC132054, BY203258
    UniProtKB/Swiss-Prot
    P58682
    Conserved Domains (4) summary
    smart00255
    Location:352488
    TIR; Toll - interleukin 1 - resistance
    cd00116
    Location:27246
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:427
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:81148
    LRR_8; Leucine rich repeat
  3. NM_133212.3NP_573475.2  toll-like receptor 8 isoform 1 precursor

    See identical proteins and their annotated locations for NP_573475.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL731735, BC132054, BY203208
    Consensus CDS
    CCDS41209.1
    UniProtKB/Swiss-Prot
    A2AHI9, P58682, Q91XI7
    Related
    ENSMUSP00000107793.2, ENSMUST00000112170.2
    Conserved Domains (4) summary
    smart00255
    Location:8711007
    TIR; Toll - interleukin 1 - resistance
    cd00116
    Location:32252
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:6588
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:600667
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    166024119..166047325 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006528719.4XP_006528782.1  toll-like receptor 8 isoform X1

    See identical proteins and their annotated locations for XP_006528782.1

    Conserved Domains (5) summary
    PRK15370
    Location:47231
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    smart00255
    Location:8681004
    TIR; Toll - interleukin 1 - resistance
    PLN00113
    Location:141717
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00033
    Location:6285
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:701762
    LRR_8; Leucine rich repeat
  2. XM_017318405.2XP_017173894.1  toll-like receptor 8 isoform X1

    Conserved Domains (5) summary
    PRK15370
    Location:47231
    PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP
    smart00255
    Location:8681004
    TIR; Toll - interleukin 1 - resistance
    PLN00113
    Location:141717
    PLN00113; leucine-rich repeat receptor-like protein kinase; Provisional
    sd00033
    Location:6285
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:701762
    LRR_8; Leucine rich repeat