Format

Send to:

Choose Destination

TLR8 toll like receptor 8 [ Homo sapiens (human) ]

Gene ID: 51311, updated on 17-Jun-2019

Summary

Official Symbol
TLR8provided by HGNC
Official Full Name
toll like receptor 8provided by HGNC
Primary source
HGNC:HGNC:15632
See related
Ensembl:ENSG00000101916 MIM:300366
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD288
Summary
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung and peripheral blood leukocytes, and lies in close proximity to another family member, TLR7, on chromosome X. [provided by RefSeq, Jul 2008]
Expression
Biased expression in appendix (RPKM 10.8), spleen (RPKM 6.1) and 9 other tissues See more
Orthologs

Genomic context

See TLR8 in Genome Data Viewer
Location:
Xp22.2
Exon count:
3
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (12906620..12923169)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (12924739..12941288)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene toll like receptor 7 Neighboring gene Sharpr-MPRA regulatory region 5588 Neighboring gene TLR8 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 4636 Neighboring gene thymosin beta 4 X-linked

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Treatment of macrophages (24 hours) with purified HIV-1 and shTLR8 indicate that HIV-1 activates TLR8 to induce autophagy at early timepoints post-HIV exposure PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env Combined activation of TLR7/8 and TLR9 by TLR7/8 and TLR9 agonists induces the highest titers of binding, neutralizing, and antibody-dependent cellular cytotoxicity-mediating antibodies against HIV-1 Env/gp140 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC119599, MGC119600

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA binding TAS
Traceable Author Statement
more info
PubMed 
double-stranded RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
drug binding IEA
Inferred from Electronic Annotation
more info
 
signaling pattern recognition receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signaling receptor activity NAS
Non-traceable Author Statement
more info
PubMed 
single-stranded RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
I-kappaB kinase/NF-kappaB signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
I-kappaB kinase/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
PubMed 
MyD88-dependent toll-like receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
cellular response to mechanical stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
defense response to virus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
defense response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
immunoglobulin mediated immune response TAS
Traceable Author Statement
more info
PubMed 
innate immune response NAS
Non-traceable Author Statement
more info
PubMed 
microglial cell activation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of interleukin-12 secretion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of innate immune response IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interferon-alpha biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interferon-beta biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of interferon-beta biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interferon-gamma biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of interferon-gamma biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interleukin-1 beta secretion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interleukin-6 production IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of interleukin-6 secretion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of interleukin-8 biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of interleukin-8 biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
response to virus IDA
Inferred from Direct Assay
more info
PubMed 
toll-like receptor 8 signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
toll-like receptor 9 signaling pathway TAS
Traceable Author Statement
more info
 
toll-like receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
Golgi membrane TAS
Traceable Author Statement
more info
 
endolysosome membrane TAS
Traceable Author Statement
more info
 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
endosome membrane TAS
Traceable Author Statement
more info
 
external side of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012882.2 RefSeqGene

    Range
    5001..21550
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_016610.4NP_057694.2  toll-like receptor 8 isoform 1

    See identical proteins and their annotated locations for NP_057694.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB445666, AF246971, AK314240, AY358296
    Consensus CDS
    CCDS14153.1
    UniProtKB/Swiss-Prot
    Q9NR97
    Related
    ENSP00000312082.5, ENST00000311912.5
    Conserved Domains (5) summary
    smart00082
    Location:790835
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:8981040
    TIR; Toll - interleukin 1 - resistance
    cd00116
    Location:504719
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:504524
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:657718
    LRR_8; Leucine rich repeat
  2. NM_138636.5NP_619542.1  toll-like receptor 8 isoform 2 precursor

    See identical proteins and their annotated locations for NP_619542.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in its 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus, compared to isoform 2.
    Source sequence(s)
    AC005859, AC139705, KC877963
    Consensus CDS
    CCDS14152.1
    UniProtKB/Swiss-Prot
    Q9NR97
    Related
    ENSP00000218032.6, ENST00000218032.6
    Conserved Domains (5) summary
    smart00082
    Location:772817
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:8801022
    TIR; Toll - interleukin 1 - resistance
    cd00116
    Location:486701
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:486506
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:639700
    LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    12906620..12923169
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011545530.2XP_011543832.1  toll-like receptor 8 isoform X1

    See identical proteins and their annotated locations for XP_011543832.1

    UniProtKB/Swiss-Prot
    Q9NR97
    Conserved Domains (5) summary
    smart00082
    Location:790835
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:8981040
    TIR; Toll - interleukin 1 - resistance
    cd00116
    Location:504719
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:504524
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:657718
    LRR_8; Leucine rich repeat
  2. XM_011545529.1XP_011543831.1  toll-like receptor 8 isoform X1

    See identical proteins and their annotated locations for XP_011543831.1

    UniProtKB/Swiss-Prot
    Q9NR97
    Conserved Domains (5) summary
    smart00082
    Location:790835
    LRRCT; Leucine rich repeat C-terminal domain
    smart00255
    Location:8981040
    TIR; Toll - interleukin 1 - resistance
    cd00116
    Location:504719
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:504524
    LRR_RI; leucine-rich repeat [structural motif]
    pfam13855
    Location:657718
    LRR_8; Leucine rich repeat
Support Center