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PPP3CB protein phosphatase 3 catalytic subunit beta [ Homo sapiens (human) ]

Gene ID: 5532, updated on 5-Aug-2022

Summary

Official Symbol
PPP3CBprovided by HGNC
Official Full Name
protein phosphatase 3 catalytic subunit betaprovided by HGNC
Primary source
HGNC:HGNC:9315
See related
Ensembl:ENSG00000107758 MIM:114106; AllianceGenome:HGNC:9315
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CNA2; CALNB; CALNA2; PP2Bbeta
Summary
Enables several functions, including calmodulin binding activity; calmodulin-dependent protein phosphatase activity; and protein phosphatase 2B binding activity. Involved in calcineurin-NFAT signaling cascade; positive regulation of transcription by RNA polymerase II; and protein dephosphorylation. Located in cytoplasm. Part of calcineurin complex. Implicated in aortic valve stenosis. Biomarker of focal segmental glomerulosclerosis and schizophrenia. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 40.2), fat (RPKM 17.4) and 24 other tissues See more
Orthologs
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Genomic context

See PPP3CB in Genome Data Viewer
Location:
10q22.2
Exon count:
18
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (73436433..73496024, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (74307846..74367439, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (75196191..75255782, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L26 pseudogene 6 Neighboring gene MSS51 mitochondrial translational activator Neighboring gene PPP3CB antisense RNA 1 (head to head) Neighboring gene ubiquitin specific peptidase 54 Neighboring gene Sharpr-MPRA regulatory region 13746 Neighboring gene RNA, U6 small nuclear 883, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120-induced dephosphorylation of KV2.1 is dependent on NMDA receptor-mediated activation of protein phosphatase 2B or calcineurin PubMed
Tat tat Induction of TNF-alpha by HIV-1 Tat is inhibited by cyclosporin A, an inhibitor of calcineurin that acts by preventing the dephosphorylation of NF-AT, suggesting Tat activates calcineurin PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calmodulin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables calmodulin binding NAS
Non-traceable Author Statement
more info
PubMed 
enables calmodulin-dependent protein phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables calmodulin-dependent protein phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables calmodulin-dependent protein phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables calmodulin-dependent protein phosphatase activity TAS
Traceable Author Statement
more info
PubMed 
enables enzyme binding IDA
Inferred from Direct Assay
more info
PubMed 
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein dimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein phosphatase 2B binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine phosphatase activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in T cell activation TAS
Traceable Author Statement
more info
PubMed 
involved_in T cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in T cell homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in T cell mediated cytotoxicity IEA
Inferred from Electronic Annotation
more info
 
involved_in T cell proliferation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in axon extension TAS
Traceable Author Statement
more info
PubMed 
involved_in calcineurin-NFAT signaling cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in calcineurin-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in calcineurin-mediated signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in calcium-ion regulated exocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in dephosphorylation TAS
Traceable Author Statement
more info
PubMed 
involved_in heart development IEA
Inferred from Electronic Annotation
more info
 
involved_in learning TAS
Traceable Author Statement
more info
PubMed 
involved_in locomotion involved in locomotory behavior IEA
Inferred from Electronic Annotation
more info
 
involved_in lymphangiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in memory TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of T cell mediated cytotoxicity IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of calcium ion import across plasma membrane IC
Inferred by Curator
more info
PubMed 
involved_in negative regulation of signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of voltage-gated calcium channel activity IC
Inferred by Curator
more info
PubMed 
involved_in positive regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of calcineurin-NFAT signaling cascade IC
Inferred by Curator
more info
PubMed 
involved_in positive regulation of calcium ion import across plasma membrane IC
Inferred by Curator
more info
PubMed 
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of voltage-gated calcium channel activity IC
Inferred by Curator
more info
PubMed 
involved_in protein dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of insulin secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of synaptic plasticity TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of synaptic vesicle endocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in response to cytokine IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction NAS
Non-traceable Author Statement
more info
PubMed 
involved_in skeletal muscle fiber development ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in T-tubule IEA
Inferred from Electronic Annotation
more info
 
located_in Z disc IEA
Inferred from Electronic Annotation
more info
 
part_of calcineurin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of calcineurin complex IC
Inferred by Curator
more info
PubMed 
part_of calcineurin complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IC
Inferred by Curator
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of protein serine/threonine phosphatase complex IC
Inferred by Curator
more info
PubMed 

General protein information

Preferred Names
serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
Names
CAM-PRP catalytic subunit
CNA beta
calcineurin A beta
calcineurin A2
protein phosphatase 3, catalytic subunit, beta isozyme
protein phosphatase from PCR fragment H32
NP_001135825.1
NP_001135826.1
NP_001276897.1
NP_001276898.1
NP_066955.1
XP_005270001.1
XP_047281382.1
XP_047281383.1
XP_047281384.1
XP_047281385.1
XP_047281386.1
XP_047281387.1
XP_047281388.1
XP_047281389.1
XP_047281390.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001142353.3NP_001135825.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform a

    See identical proteins and their annotated locations for NP_001135825.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    BC028049, BX114972, DA854064
    Consensus CDS
    CCDS44437.1
    UniProtKB/Swiss-Prot
    P16298
    Related
    ENSP00000378306.2, ENST00000394829.6
    Conserved Domains (1) summary
    cd07416
    Location:50354
    MPP_PP2B; PP2B, metallophosphatase domain
  2. NM_001142354.3NP_001135826.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform c

    See identical proteins and their annotated locations for NP_001135826.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the coding region, compared to variant 1. It encodes isoform c, which is shorter than isoform a.
    Source sequence(s)
    AJ488506, BX114972, DA854064
    Consensus CDS
    CCDS44436.1
    UniProtKB/Swiss-Prot
    P16298
    Related
    ENSP00000378305.2, ENST00000394828.6
    Conserved Domains (1) summary
    cd07416
    Location:50354
    MPP_PP2B; PP2B, metallophosphatase domain
  3. NM_001289968.2NP_001276897.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform d

    See identical proteins and their annotated locations for NP_001276897.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) has multiple differences in the coding region, one of which results in a frameshift and early stop codon, compared to variant 1. The resulting protein (isoform d) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AK301582, CA429703, DA128707, M29550
    UniProtKB/Swiss-Prot
    P16298
    UniProtKB/TrEMBL
    B7Z781
    Related
    ENSP00000343147.3, ENST00000342558.3
    Conserved Domains (2) summary
    smart00156
    Location:67356
    PP2Ac; Protein phosphatase 2A homologues, catalytic domain
    cd07416
    Location:50372
    MPP_PP2B; PP2B, metallophosphatase domain
  4. NM_001289969.2NP_001276898.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform e

    See identical proteins and their annotated locations for NP_001276898.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) has multiple differences in the coding region, one of which results in a frameshift and early stop codon, compared to variant 1. The resulting protein (isoform e) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AK301582, AL359074, CA429703, DB479220, M29550
    UniProtKB/Swiss-Prot
    P16298
    UniProtKB/TrEMBL
    B7Z781
    Conserved Domains (2) summary
    cd07416
    Location:1268
    MPP_PP2B; PP2B, metallophosphatase domain
    pfam00149
    Location:7205
    Metallophos; Calcineurin-like phosphoesterase
  5. NM_021132.4NP_066955.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform b

    See identical proteins and their annotated locations for NP_066955.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. It encodes isoform b which is shorter than isoform a.
    Source sequence(s)
    BC028049, BC035464, BX114972, DA854064
    Consensus CDS
    CCDS7328.1
    UniProtKB/Swiss-Prot
    P16298, Q8N3W4
    Related
    ENSP00000353881.5, ENST00000360663.10
    Conserved Domains (1) summary
    cd07416
    Location:50354
    MPP_PP2B; PP2B, metallophosphatase domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    73436433..73496024 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005269944.2XP_005270001.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X3

    See identical proteins and their annotated locations for XP_005270001.1

    Conserved Domains (1) summary
    cd07416
    Location:50354
    MPP_PP2B; PP2B, metallophosphatase domain
  2. XM_047425427.1XP_047281383.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X2

  3. XM_047425426.1XP_047281382.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1

  4. XM_047425430.1XP_047281386.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X4

  5. XM_047425434.1XP_047281390.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X8

  6. XM_047425432.1XP_047281388.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X6

  7. XM_047425433.1XP_047281389.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X7

  8. XM_047425431.1XP_047281387.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X5

  9. XM_047425428.1XP_047281384.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X4

  10. XM_047425429.1XP_047281385.1  serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    74307846..74367439 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)