Ppp3cb protein phosphatase 3, catalytic subunit, beta isoform [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ppp3cbprovided by MGI
Official Full Name: protein phosphatase 3, catalytic subunit, beta isoformprovided by MGI
Primary source: MGI:MGI:107163
See related: Ensembl:ENSMUSG00000021816 AllianceGenome:MGI:107163
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cnab; Calnb; CnAbeta; 1110063J16Rik
Summary: Enables calmodulin-dependent protein phosphatase activity. Involved in several processes, including calcium-ion regulated exocytosis; positive regulation of insulin secretion involved in cellular response to glucose stimulus; and regulation of synaptic vesicle endocytosis. Acts upstream of or within several processes, including circulatory system development; locomotion involved in locomotory behavior; and negative regulation of T cell mediated cytotoxicity. Located in T-tubule and Z disc. Is active in glutamatergic synapse. Is expressed in several structures, including gastrocnemius muscle; jaw skeleton; ovary; renal vasculature; and tooth. Human ortholog(s) of this gene implicated in aortic valve stenosis. Orthologous to human PPP3CB (protein phosphatase 3 catalytic subunit beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in CNS E18 (RPKM 36.0), frontal lobe adult (RPKM 32.9) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14; 14 A3

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (20549432..20596641, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (20499364..20546573, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Coexpression of calcineurin A and B subunits in various subcellular and synaptic compartments of cerebellar neurons and glia with particular abundance at parallel fiber-Purkinje cell synapses.
Title: Coexpression of calcineurin A and B subunits in various subcellular and synaptic compartments of cerebellar neurons and glia with particular abundance at parallel fiber-Purkinje cell synapses.
Calcineurin (PPP3CB) regulates angiotensin II-dependent vascular remodelling by potentiating EGFR signalling in mice.
Title: Calcineurin (PPP3CB) regulates angiotensin II-dependent vascular remodelling by potentiating EGFR signalling in mice.
Calcineurin Abeta-Specific Anchoring Confers Isoform-Specific Compartmentation and Function in Pathological Cardiac Myocyte Hypertrophy.
Title: Calcineurin Aβ-Specific Anchoring Confers Isoform-Specific Compartmentation and Function in Pathological Cardiac Myocyte Hypertrophy.
Calcineurin A beta mediates hypothalamic astrocytosis in response to acute and chronic high fat diet exposure.
Title: Calcineurin A beta deficiency ameliorates HFD-induced hypothalamic astrocytosis in mice.
Transient high ductal pressure produces pancreatic inflammation and loss of tight junction integrity via calcineurin signaling.
Title: Transient High Pressure in Pancreatic Ducts Promotes Inflammation and Alters Tight Junctions via Calcineurin Signaling in Mice.
NFAT is activated through calcineurin and interacts with NFsmall ka, CyrillicB after P. aeruginosa lung infection, and contributes to the host inflammatory response.
Title: The calcineurin-NFAT axis contributes to host defense during Pseudomonas aeruginosa lung infection.
CnAbeta1 is mainly localized at the Golgi apparatus through its C-terminal domain. CnAbeta1 is needed for mTORC2 localization and activation at the cellular membranes. CnAbeta1 regulates differentiation of mouse embryonic stem cells to mesoderm.
Title: The Calcineurin Variant CnAβ1 Controls Mouse Embryonic Stem Cell Differentiation by Directing mTORC2 Membrane Localization and Activation.
Data indicate that calcineurin (CnAalpha-/- or CnAbeta-/-) is required for pathological but not compensatory renal hypertrophy.
Title: Compensatory renal hypertrophy following uninephrectomy is calcineurin-independent.
CaM plays an active role in shaping both the spatial and temporal aspects of calcineurin-mediated calcium signaling.
Title: Calmodulin-controlled spatial decoding of oscillatory Ca2+ signals by calcineurin.
CnAbeta/NFAT pathway modulates Nox.
Title: Calcineurin Aβ regulates NADPH oxidase (Nox) expression and activity via nuclear factor of activated T cells (NFAT) in response to high glucose.

Submit: New GeneRIF Correction See all GeneRIFs (25)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (1)
Targeted (1) 1 citation
Chemically induced (ENU) (6)
Endonuclease-mediated (4)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ppp3cb (e-PCR), detects polymorphism
- UniSTS:546561

AU022835 (e-PCR)
- UniSTS:209001

Ppp3cb (e-PCR), detects polymorphism
- UniSTS:499106

Homology

Homologs of the Ppp3cb gene: The Ppp3cb gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, fruit fly, S.cerevisiae, and frog.
Orthologs from Annotation Pipeline: 333 organisms have orthologs with human gene Ppp3cb
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium-dependent protein serine/threonine phosphatase activity	ISO Inferred from Sequence Orthology more info
enables calcium-dependent protein serine/threonine phosphatase activity	TAS Traceable Author Statement more info
enables calmodulin binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables calmodulin binding	ISO Inferred from Sequence Orthology more info
enables calmodulin-dependent protein phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables calmodulin-dependent protein phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables calmodulin-dependent protein phosphatase activity	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	ISO Inferred from Sequence Orthology more info
enables protein phosphatase 2B binding	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within T cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of T cell mediated cytotoxicity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcineurin-NFAT signaling cascade	ISO Inferred from Sequence Orthology more info
involved_in calcineurin-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in calcineurin-mediated signaling	ISO Inferred from Sequence Orthology more info
involved_in calcium-ion regulated exocytosis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within locomotion involved in locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lymphangiogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of T cell mediated cytotoxicity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of calcium ion import across plasma membrane	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of voltage-gated calcium channel activity	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of calcineurin-NFAT signaling cascade	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of calcium ion import across plasma membrane	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lysosome organization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to nucleus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of voltage-gated calcium channel activity	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within protein dephosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein dephosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic vesicle endocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synaptic vesicle endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to cytokine	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in skeletal muscle fiber development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in T-tubule	IDA Inferred from Direct Assay more info	PubMed
located_in Z disc	IDA Inferred from Direct Assay more info	PubMed
part_of calcineurin complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
part_of calcineurin complex	ISO Inferred from Sequence Orthology more info
part_of calcineurin complex	NAS Non-traceable Author Statement more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	NAS Non-traceable Author Statement more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein serine/threonine phosphatase complex	NAS Non-traceable Author Statement more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
is_active_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

Names: CAM-PRP catalytic subunit; CNA beta; PP2BA beta

NP_001297355.1

EC 3.1.3.16

NP_001297356.1

EC 3.1.3.16

NP_032940.1

EC 3.1.3.16

XP_006518770.1

EC 3.1.3.16

XP_006518771.1

EC 3.1.3.16

XP_006518774.1

EC 3.1.3.16

XP_017171410.1

EC 3.1.3.16

XP_036014402.1

EC 3.1.3.16

XP_036014403.1

EC 3.1.3.16

XP_036014404.1

EC 3.1.3.16

XP_036014405.1

EC 3.1.3.16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001310426.1 → NP_001297355.1 serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. It encodes isoform 2, which is one amino acid shorter than isoform 1.

Source sequence(s)

AC146594, BC066000, BM219132, BQ175555, CJ112318

Consensus CDS

CCDS79266.1

UniProtKB/Swiss-Prot

P48453

UniProtKB/TrEMBL

A0A6P5QZ97, E0CZ78

Related

ENSMUSP00000125630.2, ENSMUST00000161445.8

Conserved Domains (1) summary

cd07416
Location:50 → 354

MPP_PP2B; PP2B, metallophosphatase domain
NM_001310427.1 → NP_001297356.1 serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform 3

See identical proteins and their annotated locations for NP_001297356.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. It encodes isoform 3 which is shorter than isoform 1.

Source sequence(s)

AA120596, AC146594, BC066000, BM219132, BQ175555, CJ112318

Consensus CDS

CCDS79267.1

UniProtKB/Swiss-Prot

P48453

UniProtKB/TrEMBL

A0A6P5QYP9, A0A8C6GPU4, G3X8U7

Related

ENSMUSP00000022355.5, ENSMUST00000022355.11

Conserved Domains (1) summary

cd07416
Location:50 → 354

MPP_PP2B; PP2B, metallophosphatase domain
NM_008914.3 → NP_032940.1 serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform 1

See identical proteins and their annotated locations for NP_032940.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC146594, BC066000, BM219132, BQ175555, CJ112318

Consensus CDS

CCDS26846.1

UniProtKB/Swiss-Prot

P48453, Q6NZR4

UniProtKB/TrEMBL

A0A6P5R4N6, A0A8C6GPH1

Related

ENSMUSP00000125722.2, ENSMUST00000159027.8

Conserved Domains (1) summary

cd07416
Location:50 → 354

MPP_PP2B; PP2B, metallophosphatase domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

20549432..20596641 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006518711.3 → XP_006518774.1 serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X4

Conserved Domains (1) summary

cd07416
Location:50 → 354

MPP_PP2B; PP2B, metallophosphatase domain
XM_036158509.1 → XP_036014402.1 serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X2

Conserved Domains (1) summary

cd07416
Location:50 → 354

MPP_PP2B; PP2B, metallophosphatase domain
XM_006518708.3 → XP_006518771.1 serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X3

Conserved Domains (1) summary

cd07416
Location:50 → 354

MPP_PP2B; PP2B, metallophosphatase domain
XM_006518707.3 → XP_006518770.1 serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X1

UniProtKB/TrEMBL

A0A6B9EQU3

Conserved Domains (1) summary

cd07416
Location:50 → 354

MPP_PP2B; PP2B, metallophosphatase domain
XM_036158510.1 → XP_036014403.1 serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X6

Conserved Domains (1) summary

cl13995
Location:1 → 167

MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain
XM_036158511.1 → XP_036014404.1 serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X7

Conserved Domains (1) summary

cl13995
Location:1 → 167

MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain
XM_017315921.3 → XP_017171410.1 serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X5

Conserved Domains (1) summary

cl13995
Location:1 → 167

MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain
XM_036158512.1 → XP_036014405.1 serine/threonine-protein phosphatase 2B catalytic subunit beta isoform isoform X8

Conserved Domains (1) summary

cl13995
Location:1 → 167

MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain