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ZNF444 zinc finger protein 444 [ Homo sapiens (human) ]

Gene ID: 55311, updated on 1-Jun-2020

Summary

Official Symbol
ZNF444provided by HGNC
Official Full Name
zinc finger protein 444provided by HGNC
Primary source
HGNC:HGNC:16052
See related
Ensembl:ENSG00000167685 MIM:607874
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EZF2; EZF-2; ZSCAN17
Summary
This gene encodes a zinc finger protein which activates transcription of a scavenger receptor gene involved in the degradation of acetylated low density lipoprotein (Ac-LDL) (PMID: 11978792). This gene is located in a cluster of zinc finger genes on chromosome 19 at q13.4. A pseudogene of this gene is located on chromosome 15. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Expression
Ubiquitous expression in prostate (RPKM 3.1), stomach (RPKM 2.9) and 25 other tissues See more
Orthologs

Genomic context

See ZNF444 in Genome Data Viewer
Location:
19q13.43
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (56132509..56160893)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (56652320..56672262)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1864 Neighboring gene zinc finger protein 787 Neighboring gene Sharpr-MPRA regulatory region 1998 Neighboring gene CRISPRi-validated cis-regulatory element chr19.6329 Neighboring gene galanin like peptide

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11137

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger protein 444
Names
endothelial zinc finger protein 2
zinc finger and SCAN domain-containing protein 17

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001253792.2NP_001240721.1  zinc finger protein 444 isoform 2

    See identical proteins and their annotated locations for NP_001240721.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter compared to isoform 1.
    Source sequence(s)
    AB052954, AC024580
    Consensus CDS
    CCDS59426.1
    UniProtKB/Swiss-Prot
    Q8N0Y2
    UniProtKB/TrEMBL
    A0A024R4P4
    Related
    ENSP00000468069.1, ENST00000592949.5
    Conserved Domains (4) summary
    COG5048
    Location:178279
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:180200
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam02023
    Location:2198
    SCAN; SCAN domain
    pfam13465
    Location:192217
    zf-H2C2_2; Zinc-finger double domain
  2. NM_018337.4NP_060807.2  zinc finger protein 444 isoform 1

    See identical proteins and their annotated locations for NP_060807.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
    Source sequence(s)
    AL834130, BI823582
    Consensus CDS
    CCDS12939.1
    UniProtKB/Swiss-Prot
    Q8N0Y2
    UniProtKB/TrEMBL
    A0A024R4S5
    Related
    ENSP00000338860.3, ENST00000337080.8
    Conserved Domains (4) summary
    COG5048
    Location:179280
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:181201
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam02023
    Location:2198
    SCAN; SCAN domain
    cl26247
    Location:60182
    DNA_pol3_delta2; DNA polymerase III, delta subunit

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    56132509..56160893
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451575.1XP_024307343.1  zinc finger protein 444 isoform X1

    Conserved Domains (4) summary
    COG5048
    Location:179280
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:181201
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam02023
    Location:2198
    SCAN; SCAN domain
    cl26247
    Location:60182
    DNA_pol3_delta2; DNA polymerase III, delta subunit
  2. XM_005259035.1XP_005259092.1  zinc finger protein 444 isoform X1

    See identical proteins and their annotated locations for XP_005259092.1

    UniProtKB/Swiss-Prot
    Q8N0Y2
    UniProtKB/TrEMBL
    A0A024R4S5
    Conserved Domains (4) summary
    COG5048
    Location:179280
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:181201
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam02023
    Location:2198
    SCAN; SCAN domain
    cl26247
    Location:60182
    DNA_pol3_delta2; DNA polymerase III, delta subunit
  3. XM_005259034.2XP_005259091.1  zinc finger protein 444 isoform X1

    See identical proteins and their annotated locations for XP_005259091.1

    UniProtKB/Swiss-Prot
    Q8N0Y2
    UniProtKB/TrEMBL
    A0A024R4S5
    Conserved Domains (4) summary
    COG5048
    Location:179280
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:181201
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam02023
    Location:2198
    SCAN; SCAN domain
    cl26247
    Location:60182
    DNA_pol3_delta2; DNA polymerase III, delta subunit
  4. XM_017026932.1XP_016882421.1  zinc finger protein 444 isoform X2

    Conserved Domains (3) summary
    COG5048
    Location:82154
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:102122
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:114139
    zf-H2C2_2; Zinc-finger double domain
  5. XM_011527070.1XP_011525372.1  zinc finger protein 444 isoform X3

    See identical proteins and their annotated locations for XP_011525372.1

    Conserved Domains (3) summary
    COG5048
    Location:48149
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:5070
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:6287
    zf-H2C2_2; Zinc-finger double domain
  6. XM_011527073.1XP_011525375.1  zinc finger protein 444 isoform X4

    Conserved Domains (3) summary
    COG5048
    Location:29101
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:4969
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:6186
    zf-H2C2_2; Zinc-finger double domain
  7. XM_011527071.1XP_011525373.1  zinc finger protein 444 isoform X3

    See identical proteins and their annotated locations for XP_011525373.1

    Conserved Domains (3) summary
    COG5048
    Location:48149
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:5070
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:6287
    zf-H2C2_2; Zinc-finger double domain
  8. XM_011527069.1XP_011525371.1  zinc finger protein 444 isoform X2

    Conserved Domains (3) summary
    COG5048
    Location:82154
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:102122
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:114139
    zf-H2C2_2; Zinc-finger double domain
  9. XM_024451573.1XP_024307341.1  zinc finger protein 444 isoform X1

    Conserved Domains (4) summary
    COG5048
    Location:179280
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:181201
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam02023
    Location:2198
    SCAN; SCAN domain
    cl26247
    Location:60182
    DNA_pol3_delta2; DNA polymerase III, delta subunit
  10. XM_005259036.1XP_005259093.1  zinc finger protein 444 isoform X1

    See identical proteins and their annotated locations for XP_005259093.1

    UniProtKB/Swiss-Prot
    Q8N0Y2
    UniProtKB/TrEMBL
    A0A024R4S5
    Conserved Domains (4) summary
    COG5048
    Location:179280
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:181201
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam02023
    Location:2198
    SCAN; SCAN domain
    cl26247
    Location:60182
    DNA_pol3_delta2; DNA polymerase III, delta subunit
  11. XM_024451574.1XP_024307342.1  zinc finger protein 444 isoform X1

    Conserved Domains (4) summary
    COG5048
    Location:179280
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:181201
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam02023
    Location:2198
    SCAN; SCAN domain
    cl26247
    Location:60182
    DNA_pol3_delta2; DNA polymerase III, delta subunit
  12. XM_024451576.1XP_024307344.1  zinc finger protein 444 isoform X1

    Conserved Domains (4) summary
    COG5048
    Location:179280
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:181201
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam02023
    Location:2198
    SCAN; SCAN domain
    cl26247
    Location:60182
    DNA_pol3_delta2; DNA polymerase III, delta subunit
  13. XM_011527068.1XP_011525370.1  zinc finger protein 444 isoform X1

    See identical proteins and their annotated locations for XP_011525370.1

    UniProtKB/Swiss-Prot
    Q8N0Y2
    UniProtKB/TrEMBL
    A0A024R4S5
    Conserved Domains (4) summary
    COG5048
    Location:179280
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:181201
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam02023
    Location:2198
    SCAN; SCAN domain
    cl26247
    Location:60182
    DNA_pol3_delta2; DNA polymerase III, delta subunit
  14. XM_017026933.1XP_016882422.1  zinc finger protein 444 isoform X2

    Conserved Domains (3) summary
    COG5048
    Location:82154
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:102122
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:114139
    zf-H2C2_2; Zinc-finger double domain
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