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ZNF444 zinc finger protein 444 [ Homo sapiens (human) ]

Gene ID: 55311, updated on 6-Sep-2022

Summary

Official Symbol
ZNF444provided by HGNC
Official Full Name
zinc finger protein 444provided by HGNC
Primary source
HGNC:HGNC:16052
See related
Ensembl:ENSG00000167685 MIM:607874; AllianceGenome:HGNC:16052
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EZF2; EZF-2; ZSCAN17
Summary
This gene encodes a zinc finger protein which activates transcription of a scavenger receptor gene involved in the degradation of acetylated low density lipoprotein (Ac-LDL) (PMID: 11978792). This gene is located in a cluster of zinc finger genes on chromosome 19 at q13.4. A pseudogene of this gene is located on chromosome 15. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Expression
Ubiquitous expression in prostate (RPKM 3.1), stomach (RPKM 2.9) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF444 in Genome Data Viewer
Location:
19q13.43
Exon count:
13
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (56132553..56160893)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (59240168..59259774)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (56652656..56672262)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 787 Neighboring gene Sharpr-MPRA regulatory region 1998 Neighboring gene uncharacterized LOC124904772 Neighboring gene CRISPRi-validated cis-regulatory element chr19.6329 Neighboring gene galanin like peptide

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ11137

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger protein 444
Names
endothelial zinc finger protein 2
zinc finger and SCAN domain-containing protein 17

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001253792.2NP_001240721.1  zinc finger protein 444 isoform 2

    See identical proteins and their annotated locations for NP_001240721.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter compared to isoform 1.
    Source sequence(s)
    AB052954, AC024580
    Consensus CDS
    CCDS59426.1
    UniProtKB/Swiss-Prot
    Q8N0Y2
    UniProtKB/TrEMBL
    A0A024R4P4
    Related
    ENSP00000468069.1, ENST00000592949.5
    Conserved Domains (5) summary
    PRK14959
    Location:60181
    PRK14959; DNA polymerase III subunits gamma and tau; Provisional
    COG5048
    Location:178279
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:180200
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:277299
    zf-C2H2; Zinc finger, C2H2 type
    pfam02023
    Location:2198
    SCAN; SCAN domain
  2. NM_018337.4NP_060807.2  zinc finger protein 444 isoform 1

    See identical proteins and their annotated locations for NP_060807.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
    Source sequence(s)
    AL834130, BI823582
    Consensus CDS
    CCDS12939.1
    UniProtKB/Swiss-Prot
    Q8N0Y2, Q9NUU1
    UniProtKB/TrEMBL
    A0A024R4S5
    Related
    ENSP00000338860.3, ENST00000337080.8
    Conserved Domains (5) summary
    PRK14959
    Location:60182
    PRK14959; DNA polymerase III subunits gamma and tau; Provisional
    COG5048
    Location:179280
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:181201
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:278300
    zf-C2H2; Zinc finger, C2H2 type
    pfam02023
    Location:2198
    SCAN; SCAN domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    56132553..56160893
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451575.2XP_024307343.1  zinc finger protein 444 isoform X1

    UniProtKB/Swiss-Prot
    Q9NUU1
    UniProtKB/TrEMBL
    A0A024R4S5
    Conserved Domains (5) summary
    PRK14959
    Location:60182
    PRK14959; DNA polymerase III subunits gamma and tau; Provisional
    COG5048
    Location:179280
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:181201
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:278300
    zf-C2H2; Zinc finger, C2H2 type
    pfam02023
    Location:2198
    SCAN; SCAN domain
  2. XM_005259035.2XP_005259092.1  zinc finger protein 444 isoform X1

    See identical proteins and their annotated locations for XP_005259092.1

    UniProtKB/Swiss-Prot
    Q8N0Y2, Q9NUU1
    UniProtKB/TrEMBL
    A0A024R4S5
    Conserved Domains (5) summary
    PRK14959
    Location:60182
    PRK14959; DNA polymerase III subunits gamma and tau; Provisional
    COG5048
    Location:179280
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:181201
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:278300
    zf-C2H2; Zinc finger, C2H2 type
    pfam02023
    Location:2198
    SCAN; SCAN domain
  3. XM_047439042.1XP_047294998.1  zinc finger protein 444 isoform X2

    UniProtKB/TrEMBL
    A0A024R4P4
  4. XM_005259034.3XP_005259091.1  zinc finger protein 444 isoform X1

    See identical proteins and their annotated locations for XP_005259091.1

    UniProtKB/Swiss-Prot
    Q8N0Y2, Q9NUU1
    UniProtKB/TrEMBL
    A0A024R4S5
    Conserved Domains (5) summary
    PRK14959
    Location:60182
    PRK14959; DNA polymerase III subunits gamma and tau; Provisional
    COG5048
    Location:179280
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:181201
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:278300
    zf-C2H2; Zinc finger, C2H2 type
    pfam02023
    Location:2198
    SCAN; SCAN domain
  5. XM_047439039.1XP_047294995.1  zinc finger protein 444 isoform X1

    UniProtKB/Swiss-Prot
    Q9NUU1
    UniProtKB/TrEMBL
    A0A024R4S5
  6. XM_047439038.1XP_047294994.1  zinc finger protein 444 isoform X1

    UniProtKB/Swiss-Prot
    Q9NUU1
    UniProtKB/TrEMBL
    A0A024R4S5
  7. XM_047439037.1XP_047294993.1  zinc finger protein 444 isoform X1

    UniProtKB/Swiss-Prot
    Q9NUU1
    UniProtKB/TrEMBL
    A0A024R4S5
  8. XM_024451573.2XP_024307341.1  zinc finger protein 444 isoform X1

    UniProtKB/Swiss-Prot
    Q9NUU1
    UniProtKB/TrEMBL
    A0A024R4S5
    Conserved Domains (5) summary
    PRK14959
    Location:60182
    PRK14959; DNA polymerase III subunits gamma and tau; Provisional
    COG5048
    Location:179280
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:181201
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:278300
    zf-C2H2; Zinc finger, C2H2 type
    pfam02023
    Location:2198
    SCAN; SCAN domain
  9. XM_047439041.1XP_047294997.1  zinc finger protein 444 isoform X2

    UniProtKB/TrEMBL
    A0A024R4P4
  10. XM_005259036.2XP_005259093.1  zinc finger protein 444 isoform X1

    See identical proteins and their annotated locations for XP_005259093.1

    UniProtKB/Swiss-Prot
    Q8N0Y2, Q9NUU1
    UniProtKB/TrEMBL
    A0A024R4S5
    Conserved Domains (5) summary
    PRK14959
    Location:60182
    PRK14959; DNA polymerase III subunits gamma and tau; Provisional
    COG5048
    Location:179280
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:181201
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:278300
    zf-C2H2; Zinc finger, C2H2 type
    pfam02023
    Location:2198
    SCAN; SCAN domain
  11. XM_047439043.1XP_047294999.1  zinc finger protein 444 isoform X2

    UniProtKB/TrEMBL
    A0A024R4P4
  12. XM_024451576.1XP_024307344.1  zinc finger protein 444 isoform X1

    UniProtKB/Swiss-Prot
    Q9NUU1
    UniProtKB/TrEMBL
    A0A024R4S5
    Conserved Domains (5) summary
    PRK14959
    Location:60182
    PRK14959; DNA polymerase III subunits gamma and tau; Provisional
    COG5048
    Location:179280
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:181201
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:278300
    zf-C2H2; Zinc finger, C2H2 type
    pfam02023
    Location:2198
    SCAN; SCAN domain
  13. XM_047439044.1XP_047295000.1  zinc finger protein 444 isoform X2

    UniProtKB/TrEMBL
    A0A024R4P4
  14. XM_047439040.1XP_047294996.1  zinc finger protein 444 isoform X1

    UniProtKB/Swiss-Prot
    Q9NUU1
    UniProtKB/TrEMBL
    A0A024R4S5
  15. XM_017026933.2XP_016882422.1  zinc finger protein 444 isoform X3

    Conserved Domains (3) summary
    COG5048
    Location:82154
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:102122
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:114139
    zf-H2C2_2; Zinc-finger double domain
  16. XM_047439045.1XP_047295001.1  zinc finger protein 444 isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    59240168..59259774
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)