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PPP2R2C protein phosphatase 2 regulatory subunit Bgamma [ Homo sapiens (human) ]

Gene ID: 5522, updated on 7-Oct-2018

Summary

Official Symbol
PPP2R2Cprovided by HGNC
Official Full Name
protein phosphatase 2 regulatory subunit Bgammaprovided by HGNC
Primary source
HGNC:HGNC:9306
See related
Ensembl:ENSG00000074211 MIM:605997; Vega:OTTHUMG00000090445
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PR52; PR55G; IMYPNO; IMYPNO1; B55gamma; B55-GAMMA
Summary
The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 39.0), endometrium (RPKM 11.7) and 4 other tissues See more
Orthologs

Genomic context

See PPP2R2C in Genome Data Viewer
Location:
4p16.1
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 4 NC_000004.12 (6320578..6563600, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (6322305..6565327, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene VISTA enhancer hs1979 Neighboring gene wolframin ER transmembrane glycoprotein Neighboring gene uncharacterized LOC107986257 Neighboring gene uncharacterized LOC105374365 Neighboring gene mannosidase alpha class 2B member 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the total levels of PP2A protein and downregulates the inactive form of phosphorylated PP2A, which leads to inhibit hTERT activity directly or indirectly in CD4+ T cells PubMed
tat Protein phosphatase-2A (PP2A) and protein phosphatase-1 (PP1) regulate HIV-1 Tat-activated transcription through dephosphorylation of CDK9 PubMed
tat An increase in the amount of PP2A core enzyme with a concomitant decrease in the amount of PP2A holoenzyme inhibits HIV-1 Tat-stimulated transcription from the HIV-1 LTR promoter, indicating a role for PP2A in the modulation of HIV-1 gene expression PubMed
Vpr vpr HIV-1 Vpr cell death causing peptide (amino acid residues 71-96) can activate the expression of PP2A when applied extracellularly to CD4+ T cells as well as cause the activation of PP2A from brain, liver, and adipose tissues PubMed
vpr HIV-1 Vpr was found to upregulate PP2A in fission yeast PubMed
vpr HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A PubMed
nucleocapsid gag HIV-1 Vpr forms a complex with HIV-1 nucleocapsid that directly activates PP2A PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • AMPK signaling pathway, organism-specific biosystem (from KEGG)
    AMPK signaling pathway, organism-specific biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
  • AMPK signaling pathway, conserved biosystem (from KEGG)
    AMPK signaling pathway, conserved biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
  • Adrenergic signaling in cardiomyocytes, organism-specific biosystem (from KEGG)
    Adrenergic signaling in cardiomyocytes, organism-specific biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
  • Adrenergic signaling in cardiomyocytes, conserved biosystem (from KEGG)
    Adrenergic signaling in cardiomyocytes, conserved biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
  • Chagas disease (American trypanosomiasis), organism-specific biosystem (from KEGG)
    Chagas disease (American trypanosomiasis), organism-specific biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
  • Chagas disease (American trypanosomiasis), conserved biosystem (from KEGG)
    Chagas disease (American trypanosomiasis), conserved biosystemTrypanosoma cruzi is an intracellular protozoan parasite that causes Chagas disease. The parasite life cycle involves hematophagous reduviid bugs as vectors. Once parasites enter the host body, they ...
  • Dopaminergic synapse, organism-specific biosystem (from KEGG)
    Dopaminergic synapse, organism-specific biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
  • Dopaminergic synapse, conserved biosystem (from KEGG)
    Dopaminergic synapse, conserved biosystemDopamine (DA) is an important and prototypical slow neurotransmitter in the mammalian brain, where it controls a variety of functions including locomotor activity, motivation and reward, learning an...
  • Glycogen Metabolism, organism-specific biosystem (from WikiPathways)
    Glycogen Metabolism, organism-specific biosystemGlycogen is a very large, branched polymer of glucose residues. Within skeletal muscle and liver glucose is stored as glycogen. In the liver, glycogen synthesis and degradation are regulated to maint...
  • Hepatitis C, organism-specific biosystem (from KEGG)
    Hepatitis C, organism-specific biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
  • Hepatitis C, conserved biosystem (from KEGG)
    Hepatitis C, conserved biosystemHepatitis C virus (HCV) is a major cause of chronic liver disease. The HCV employ several strategies to perturb host cell immunity. After invasion, HCV RNA genome functions directly as an mRNA in the...
  • Hippo signaling pathway, organism-specific biosystem (from KEGG)
    Hippo signaling pathway, organism-specific biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
  • Hippo signaling pathway, conserved biosystem (from KEGG)
    Hippo signaling pathway, conserved biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
  • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
    PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
    PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • Sphingolipid signaling pathway, organism-specific biosystem (from KEGG)
    Sphingolipid signaling pathway, organism-specific biosystemSphingomyelin (SM) and its metabolic products are now known to have second messenger functions in a variety of cellular signaling pathways. Particularly, the sphingolipid metabolites, ceramide (Cer) ...
  • Sphingolipid signaling pathway, conserved biosystem (from KEGG)
    Sphingolipid signaling pathway, conserved biosystemSphingomyelin (SM) and its metabolic products are now known to have second messenger functions in a variety of cellular signaling pathways. Particularly, the sphingolipid metabolites, ceramide (Cer) ...
  • Tight junction, organism-specific biosystem (from KEGG)
    Tight junction, organism-specific biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
  • Tight junction, conserved biosystem (from KEGG)
    Tight junction, conserved biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
  • Wnt Signaling Pathway and Pluripotency, organism-specific biosystem (from WikiPathways)
    Wnt Signaling Pathway and Pluripotency, organism-specific biosystemThis pathway was adapted from several resources and is designed to provide a theoretical frame-work for examining Wnt signaling and interacting components in the context of embryonic stem-cell plurip...
  • mRNA surveillance pathway, organism-specific biosystem (from KEGG)
    mRNA surveillance pathway, organism-specific biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...
  • mRNA surveillance pathway, conserved biosystem (from KEGG)
    mRNA surveillance pathway, conserved biosystemThe mRNA surveillance pathway is a quality control mechanism that detects and degrades abnormal mRNAs. These pathways include nonsense-mediated mRNA decay (NMD), nonstop mRNA decay (NSD), and no-go ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC33570

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase regulator activity NAS
Non-traceable Author Statement
more info
PubMed 
contributes_to protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-serine dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphatase type 2A complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphatase type 2A complex NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
protein phosphatase 2, regulatory subunit B, gamma
Names
PP2A, subunit B, B-gamma isoform
PP2A, subunit B, B55-gamma isoform
PP2A, subunit B, PR55-gamma isoform
PP2A, subunit B, R2-gamma isoform
gamma isoform of regulatory subunit B55, protein phosphatase 2
phosphoprotein phosphatase 2A BR gamma regulatory chain
protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), gamma isoform
protein phosphatase 2A1 B gamma subunit
serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform
NP_001193923.1
NP_001193924.1
NP_001193925.1
NP_065149.2
NP_870991.1
XP_005248036.1
XP_011511797.1
XP_011511798.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029233.1 RefSeqGene

    Range
    5001..248023
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001206994.1NP_001193923.1  protein phosphatase 2, regulatory subunit B, gamma isoform c

    See identical proteins and their annotated locations for NP_001193923.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains alternate 5' exon structure, and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (c) has a distinct N-terminus and is shorter than isoform a. Both variants 3 and 4 encode isoform c.
    Source sequence(s)
    AC116317, AK296474, BC045682
    Consensus CDS
    CCDS56305.1
    UniProtKB/Swiss-Prot
    Q9Y2T4
    Related
    ENSP00000423649.1, OTTHUMP00000217568, ENST00000506140.5, OTTHUMT00000359298
    Conserved Domains (2) summary
    COG5170
    Location:17431
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:2068
    7WD40; WD40 repeat [structural motif]
  2. NM_001206995.1NP_001193924.1  protein phosphatase 2, regulatory subunit B, gamma isoform c

    See identical proteins and their annotated locations for NP_001193924.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains alternate 5' exon structure, and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (c) has a distinct N-terminus and is shorter than isoform a. Both variants 3 and 4 encode isoform c.
    Source sequence(s)
    AC116317, AK316003, BC045682, DC327075
    Consensus CDS
    CCDS56305.1
    UniProtKB/Swiss-Prot
    Q9Y2T4
    Related
    ENSP00000425247.1, OTTHUMP00000217634, ENST00000507294.1, OTTHUMT00000359369
    Conserved Domains (2) summary
    COG5170
    Location:17431
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:2068
    7WD40; WD40 repeat [structural motif]
  3. NM_001206996.1NP_001193925.1  protein phosphatase 2, regulatory subunit B, gamma isoform d

    See identical proteins and their annotated locations for NP_001193925.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains alternate 5' exon structure, and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (d) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AC116317, BC032954, BC045682
    Consensus CDS
    CCDS56304.1
    UniProtKB/Swiss-Prot
    Q9Y2T4
    Related
    ENSP00000422374.1, OTTHUMP00000217635, ENST00000515571.5, OTTHUMT00000359381
    Conserved Domains (2) summary
    COG5170
    Location:7421
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:1058
    7WD40; WD40 repeat [structural motif]
  4. NM_001363388.1NP_001350317.1  protein phosphatase 2, regulatory subunit B, gamma isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses an alternate 5' splice site and is predicted to use an alternate start codon, compared to variant 1. This variant encodes a protein (isoform e) with a shorter and distinct N-terminus, compared to isoform a.
    Source sequence(s)
    AC114815, AC116317
    Conserved Domains (2) summary
    COG5170
    Location:8424
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:1361
    7WD40; WD40 repeat [structural motif]
  5. NM_020416.3NP_065149.2  protein phosphatase 2, regulatory subunit B, gamma isoform a

    See identical proteins and their annotated locations for NP_065149.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform a.
    Source sequence(s)
    AC116317, AK093115, BM551976
    Consensus CDS
    CCDS3387.1
    UniProtKB/Swiss-Prot
    Q9Y2T4
    Related
    ENSP00000372042.4, OTTHUMP00000115505, ENST00000382599.8, OTTHUMT00000206889
    Conserved Domains (2) summary
    COG5170
    Location:21438
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:2775
    7WD40; WD40 repeat [structural motif]
  6. NM_181876.2NP_870991.1  protein phosphatase 2, regulatory subunit B, gamma isoform b

    See identical proteins and their annotated locations for NP_870991.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is the same length as isoform a.
    Source sequence(s)
    AC116317, AK093115
    Consensus CDS
    CCDS3388.1
    UniProtKB/Swiss-Prot
    Q9Y2T4
    Related
    ENSP00000335083.5, OTTHUMP00000115506, ENST00000335585.9, OTTHUMT00000206890
    Conserved Domains (2) summary
    COG5170
    Location:22438
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:2775
    7WD40; WD40 repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p12 Primary Assembly

    Range
    6320578..6563600 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011513495.1XP_011511797.1  protein phosphatase 2, regulatory subunit B, gamma isoform X1

    Conserved Domains (2) summary
    COG5170
    Location:8424
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:1361
    7WD40; WD40 repeat [structural motif]
  2. XM_011513496.1XP_011511798.1  protein phosphatase 2, regulatory subunit B, gamma isoform X2

    See identical proteins and their annotated locations for XP_011511798.1

    Conserved Domains (2) summary
    COG5170
    Location:2283
    CDC55; Serine/threonine protein phosphatase 2A, regulatory subunit [Signal transduction mechanisms]
    sd00039
    Location:2156
    7WD40; WD40 repeat [structural motif]
  3. XM_005247979.4XP_005248036.1  protein phosphatase 2, regulatory subunit B, gamma isoform X3

    Conserved Domains (2) summary
    sd00039
    Location:960
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:16149
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
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