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FEBS Lett. 2013 Dec 11;587(24):3892-7. doi: 10.1016/j.febslet.2013.09.029. Epub 2013 Oct 11.

Over expression of PPP2R2C inhibits human glioma cells growth through the suppression of mTOR pathway.

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1
Department of Neurosurgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China.

Abstract

PPP2R2C encodes a gamma isoform of the subunit B55 subfamily, which is a regulatory subunit of Protein phosphatase type 2A (PP2A). Our study shows that PPP2R2C is downregulated in glioma cells and human brain cancer patient samples. Overexpression of PPP2R2C inhibited cancer cell proliferation both in vitro and in vivo through the suppression of the activity of S6K in the mTOR pathway. Moreover, exogenous expression of PPP2R2C promoted the formation of a complex with the PP2A-C subunit to further enhance the binding of PP2A-C with S6K. Our results suggest that PPP2R2C is a potential tumor suppressor gene in human brain cancers. This study will provide novel insight into the development of therapeutic strategies in the treatment of human brain tumors.

KEYWORDS:

B55 Gamma; PPP2R2C; mTOR; p-S6K

PMID:
24126060
DOI:
10.1016/j.febslet.2013.09.029
[Indexed for MEDLINE]
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