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PPM1G protein phosphatase, Mg2+/Mn2+ dependent 1G [ Homo sapiens (human) ]

Gene ID: 5496, updated on 12-May-2019

Summary

Official Symbol
PPM1Gprovided by HGNC
Official Full Name
protein phosphatase, Mg2+/Mn2+ dependent 1Gprovided by HGNC
Primary source
HGNC:HGNC:9278
See related
Ensembl:ENSG00000115241 MIM:605119
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PP2CG; PPP2CG; PP2CGAMMA
Summary
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase is found to be responsible for the dephosphorylation of Pre-mRNA splicing factors, which is important for the formation of functional spliceosome. Studies of a similar gene in mice suggested a role of this phosphatase in regulating cell cycle progression. [provided by RefSeq, Apr 2010]
Expression
Broad expression in testis (RPKM 133.0), lymph node (RPKM 28.8) and 24 other tissues See more
Orthologs

Genomic context

See PPM1G in Genome Data Viewer
Location:
2p23.3
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (27381199..27409683, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (27604066..27632550, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 2B subunit delta Neighboring gene sorting nexin 17 Neighboring gene zinc finger protein 513 Neighboring gene ferritin heavy chain 1 pseudogene 3 Neighboring gene nuclear receptor binding protein 1 Neighboring gene keratinocyte associated protein 3 Neighboring gene intraflagellar transport 172

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Loss of PPM1G expression by siRNA results in downregulation of HIV-1 Gag production in cells and CA in virions, indicating that HIV-1 transcription is regulated by PPM1G PubMed
Tat tat HIV-1 Tat binds PPM1G and the activation domain (residues 1-48) of Tat and the acidic domain of PPM1G are required to the binding. Tat mutant K41A abolishes the binding PubMed
tat HIV-1 Tat recruits PPM1G phosphatase protein to dephosphorylate the T loop of CDK9 and release P-TEFb from the 7SK snRNP complex PubMed
tat HIV-1 Tat complexes with LARP7, MEPCE, SART3, NPM1, PPM1G, hnRNP-F, and 7SK RNA to form a Tat-7SK RNP complex to control HIV-1 transcription PubMed
tat HIV-1 Tat is identified to have a physical interaction with protein phosphatase, Mg2+/Mn2+ dependent, 1G (PPM1G) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
capsid gag Loss of PPM1G expression by siRNA results in downregulation of HIV-1 Gag production in cells and CA in virions, indicating that HIV-1 transcription is regulated by PPM1G PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • mRNA Processing, organism-specific biosystem (from WikiPathways)
    mRNA Processing, organism-specific biosystemThis process describes the conversion of precursor messenger RNA into mature messenger RNA (mRNA). The pre-mRNA molecule undergoes three main modifications. These modifications are 5' capping, 3' po...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC1675, MGC2870

Gene Ontology Provided by GOA

Function Evidence Code Pubs
magnesium-dependent protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cell cycle arrest IEA
Inferred from Electronic Annotation
more info
 
peptidyl-threonine dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
protein dephosphorylation TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
protein phosphatase 1G
Names
PP2C-gamma
protein phosphatase 1C
protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform
protein phosphatase 2, catalytic subunit, gamma isoform
protein phosphatase 2C gamma isoform
protein phosphatase 2C isoform gamma
protein phosphatase magnesium-dependent 1 gamma
NP_817092.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177983.3NP_817092.1  protein phosphatase 1G

    See identical proteins and their annotated locations for NP_817092.1

    Status: REVIEWED

    Source sequence(s)
    BC000057, DA520893
    Consensus CDS
    CCDS1752.1
    UniProtKB/Swiss-Prot
    O15355
    UniProtKB/TrEMBL
    Q6IAU5
    Related
    ENSP00000342778.4, ENST00000344034.5
    Conserved Domains (2) summary
    smart00332
    Location:25110
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain
    cd00143
    Location:324505
    PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    27381199..27409683 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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