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QPCTL glutaminyl-peptide cyclotransferase like [ Homo sapiens (human) ]

Gene ID: 54814, updated on 21-Apr-2019

Summary

Official Symbol
QPCTLprovided by HGNC
Official Full Name
glutaminyl-peptide cyclotransferase likeprovided by HGNC
Primary source
HGNC:HGNC:25952
See related
Ensembl:ENSG00000011478
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
gQC
Expression
Ubiquitous expression in thyroid (RPKM 3.4), prostate (RPKM 3.3) and 25 other tissues See more
Orthologs

Genomic context

See QPCTL in Genome Data Viewer
Location:
19q13.32
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (45692400..45703990)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (46195741..46207248)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene gastric inhibitory polypeptide receptor Neighboring gene microRNA 642a Neighboring gene microRNA 642b Neighboring gene small nuclear ribonucleoprotein D2 polypeptide Neighboring gene F-box protein 46 Neighboring gene basic helix-loop-helix and HMG-box containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
NHGRI GWA Catalog
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
NHGRI GWA Catalog
Meta-analysis identifies common variants associated with body mass index in east Asians.
NHGRI GWA Catalog
Meta-analysis of genome-wide association studies in East Asian-ancestry populations identifies four new loci for body mass index.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with QPCTL; predicted interaction to be within the Golgi PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ20084

Gene Ontology Provided by GOA

Function Evidence Code Pubs
glutaminyl-peptide cyclotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 

General protein information

Preferred Names
glutaminyl-peptide cyclotransferase-like protein
Names
glutaminyl cyclase-like
golgi-resident glutaminyl-peptide cyclotransferase
isoQC
NP_001156849.1
NP_060129.2
XP_011525350.1
XP_016882389.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163377.1NP_001156849.1  glutaminyl-peptide cyclotransferase-like protein isoform 2

    See identical proteins and their annotated locations for NP_001156849.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AC007191, AK222636, BC011553, BP216511
    Consensus CDS
    CCDS54282.1
    UniProtKB/Swiss-Prot
    Q9NXS2
    Related
    ENSP00000387944.2, ENST00000366382.8
    Conserved Domains (1) summary
    cl14876
    Location:116285
    Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42
  2. NM_017659.4NP_060129.2  glutaminyl-peptide cyclotransferase-like protein isoform 1

    See identical proteins and their annotated locations for NP_060129.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC007191, AK000091, AK222636, BC011553, BP216511
    Consensus CDS
    CCDS12672.1
    UniProtKB/Swiss-Prot
    Q9NXS2
    Related
    ENSP00000012049.4, ENST00000012049.10
    Conserved Domains (1) summary
    cd03880
    Location:79379
    M28_QC_like; M28 Zn-Peptidase Glutaminyl Cyclase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    45692400..45703990
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011527048.3XP_011525350.1  glutaminyl-peptide cyclotransferase-like protein isoform X2

    Conserved Domains (1) summary
    cl14876
    Location:79191
    Zinc_peptidase_like; Zinc peptidases M18, M20, M28, and M42
  2. XM_017026900.1XP_016882389.1  glutaminyl-peptide cyclotransferase-like protein isoform X1

RNA

  1. XR_001753711.1 RNA Sequence

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