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IL17RD interleukin 17 receptor D [ Homo sapiens (human) ]

Gene ID: 54756, updated on 17-May-2020

Summary

Official Symbol
IL17RDprovided by HGNC
Official Full Name
interleukin 17 receptor Dprovided by HGNC
Primary source
HGNC:HGNC:17616
See related
Ensembl:ENSG00000144730 MIM:606807
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SEF; HH18; IL-17RD; IL17RLM
Summary
This gene encodes a membrane protein belonging to the interleukin-17 receptor (IL-17R) protein family. The encoded protein is a component of the interleukin-17 receptor signaling complex, and the interaction between this protein and IL-17R does not require the interleukin. The gene product also affects fibroblast growth factor signaling, inhibiting or stimulating growth through MAPK/ERK signaling. Alternate splicing generates multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016]
Expression
Broad expression in endometrium (RPKM 8.3), testis (RPKM 6.2) and 14 other tissues See more
Orthologs

Genomic context

See IL17RD in Genome Data Viewer
Location:
3p14.3
Exon count:
16
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (57089982..57170317, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (57124010..57204345, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene Rho guanine nucleotide exchange factor 3 Neighboring gene Sharpr-MPRA regulatory region 6639 Neighboring gene spermatogenesis associated 12 Neighboring gene uncharacterized LOC105377101 Neighboring gene ribosomal protein L19 pseudogene 2 Neighboring gene HESX homeobox 1 Neighboring gene uncharacterized LOC105377102 Neighboring gene adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 Neighboring gene ankyrin repeat and SOCS box containing 14

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ35755, MGC133309, DKFZp434N1928

Gene Ontology Provided by GOA

Function Evidence Code Pubs
interleukin-17 receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
MAPK cascade TAS
Traceable Author Statement
more info
 
cytokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
Golgi membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
interleukin-17 receptor D
Names
IL-17 receptor D
IL17Rhom
interleukin-17 receptor-like protein
sef homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047158.1 RefSeqGene

    Range
    9965..85336
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001318864.1NP_001305793.1  interleukin-17 receptor D isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start site, compared to variant 2. It encodes a shorter isoform (b) which has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AC097358, AF494211, BQ017683, HY005493
    Consensus CDS
    CCDS82790.1
    UniProtKB/Swiss-Prot
    Q8NFM7
    Related
    ENSP00000322250.5, ENST00000320057.9
    Conserved Domains (2) summary
    pfam08357
    Location:212367
    SEFIR; SEFIR domain
    pfam16742
    Location:125
    IL17R_D_N; N-terminus of interleukin 17 receptor D
  2. NM_017563.5NP_060033.3  interleukin-17 receptor D isoform a precursor

    See identical proteins and their annotated locations for NP_060033.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the shorter transcript and encodes the longer isoform a (also known as hSef-a).
    Source sequence(s)
    AC097358, AF458067, AK302045, BQ017683, HY024286
    Consensus CDS
    CCDS2880.2
    UniProtKB/Swiss-Prot
    Q8NFM7
    UniProtKB/TrEMBL
    B4DXM5
    Related
    ENSP00000296318.7, ENST00000296318.12
    Conserved Domains (2) summary
    pfam08357
    Location:356511
    SEFIR; SEFIR domain
    pfam16742
    Location:48169
    IL17R_D_N; N-terminus of interleukin 17 receptor D

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    57089982..57170317 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005265238.4XP_005265295.1  interleukin-17 receptor D isoform X2

    Conserved Domains (2) summary
    pfam08357
    Location:328483
    SEFIR; SEFIR domain
    pfam16742
    Location:20141
    IL17R_D_N; N-terminus of interleukin 17 receptor D
  2. XM_011533849.2XP_011532151.2  interleukin-17 receptor D isoform X1

    UniProtKB/Swiss-Prot
    Q8NFM7
    Related
    ENSP00000417516.1, ENST00000463523.5
    Conserved Domains (2) summary
    pfam08357
    Location:212367
    SEFIR; SEFIR domain
    pfam16742
    Location:125
    IL17R_D_N; N-terminus of interleukin 17 receptor D
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