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IL17RD interleukin 17 receptor D [ Homo sapiens (human) ]

Gene ID: 54756, updated on 2-Nov-2024

Summary

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Official Symbol
IL17RDprovided by HGNC
Official Full Name
interleukin 17 receptor Dprovided by HGNC
Primary source
HGNC:HGNC:17616
See related
Ensembl:ENSG00000144730 MIM:606807; AllianceGenome:HGNC:17616
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SEF; HH18; IL-17RD; IL17RLM
Summary
This gene encodes a membrane protein belonging to the interleukin-17 receptor (IL-17R) protein family. The encoded protein is a component of the interleukin-17 receptor signaling complex, and the interaction between this protein and IL-17R does not require the interleukin. The gene product also affects fibroblast growth factor signaling, inhibiting or stimulating growth through MAPK/ERK signaling. Alternate splicing generates multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016]
Expression
Broad expression in endometrium (RPKM 8.3), testis (RPKM 6.2) and 14 other tissues See more
Orthologs
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Genomic context

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See IL17RD in Genome Data Viewer
Location:
3p14.3
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (57089982..57170317, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (57130265..57210589, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (57124010..57204345, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene Rho guanine nucleotide exchange factor 3 Neighboring gene ARHGEF3 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:57040522-57041053 Neighboring gene Sharpr-MPRA regulatory region 6639 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:57049075-57049840 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:57086410-57086910 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:57086911-57087411 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:57097817-57098598 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19985 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14476 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14477 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:57131244-57132443 Neighboring gene spermatogenesis associated 12 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:57144939-57145652 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr3:57162623-57163448 and GRCh37_chr3:57163449-57164275 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:57165102-57165928 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:57164276-57165101 Neighboring gene uncharacterized LOC105377101 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:57192947-57193632 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:57193633-57194316 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14478 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14479 Neighboring gene ribosomal protein L19 pseudogene 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:57218732-57218927 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:57233699-57234296 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14480 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19986 Neighboring gene HESX homeobox 1 Neighboring gene uncharacterized LOC105377102 Neighboring gene adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 Neighboring gene ankyrin repeat and SOCS box containing 14

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Alternative splicing generates an isoform of the human Sef gene with altered subcellular localization and specificity. Preger E, et al. Proc Natl Acad Sci U S A, 2004 Feb 3. PMID 14742870, Free PMC Article
  2. Sef is an inhibitor of proinflammatory cytokine signaling, acting by cytoplasmic sequestration of NF-κB. Fuchs Y, et al. Dev Cell, 2012 Sep 11. PMID 22975329
  3. Similar expression to FGF (Sef) reduces endometrial adenocarcinoma cells proliferation via inhibiting fibroblast growth factor 2-mediated MAPK/ERK signaling pathway. Zhang H, et al. Gynecol Oncol, 2011 Sep. PMID 21663947
  4. IL-17RD (Sef or IL-17RLM) interacts with IL-17 receptor and mediates IL-17 signaling. Rong Z, et al. Cell Res, 2009 Feb. PMID 19079364, Free PMC Article
  5. Sef Regulates Epithelial-Mesenchymal Transition in Breast Cancer Cells. He Q, et al. J Cell Biochem, 2016 Oct. PMID 26950413, Free PMC Article

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Prevalence and associated phenotypes of DUSP6, IL17RD and SPRY4 variants in a large Chinese cohort with isolated hypogonadotropic hypogonadism.
    Title: Prevalence and associated phenotypes of DUSP6, IL17RD and SPRY4 variants in a large Chinese cohort with isolated hypogonadotropic hypogonadism.
  2. Elevation of circ-PITX1 upregulates interleukin 17 receptor D expression via sponging miR-518a-5p and facilitates cell progression in glioma.
    Title: Elevation of circ-PITX1 upregulates interleukin 17 receptor D expression via sponging miR-518a-5p and facilitates cell progression in glioma.
  3. This study provides new insights into structure-function relation of Sef protein and the molecular mechanism by which Sef serves to limit classical NF-kappaB transcriptional activity.
    Title: The tumor suppressor Sef is a scaffold for the classical NF-κB/RELA:P50 signaling module.
  4. IL-17RD is a functional receptor for IL-17A in vitro and in vivo and mediates the proinflammatory gene expression downstream of IL-17A..
    Title: Interleukin-17 receptor D constitutes an alternative receptor for interleukin-17A important in psoriasis-like skin inflammation.
  5. MAPK signaling dependency in epithelial lung cancer cells is due to the scaffold protein interleukin-17 receptor D (IL17RD), which is directly repressed by ZEB1.
    Title: ZEB1 suppression sensitizes KRAS mutant cancers to MEK inhibition by an IL17RD-dependent mechanism.
  6. miR-193a-3p is downregulated in ulcerative colitis neoplasia, and its loss promotes carcinogenesis through upregulation of IL17RD. These findings provide novel insight into inflammation-driven colorectal cancer and could suggest new therapeutic targets in this high-risk population
    Title: miR-193a-3p is a Key Tumor Suppressor in Ulcerative Colitis-Associated Colon Cancer and Promotes Carcinogenesis through Upregulation of IL17RD.
  7. Low SEF expression is associated with Epithelial-Mesenchymal Transition in Breast Cancer and thus Metastasis in breast Cancer.
    Title: Sef Regulates Epithelial-Mesenchymal Transition in Breast Cancer Cells.
  8. Taken together, these data suggest evidence that loss of hSef may be a critical event facilitating tumor dissemination of prostate cancer through alteration of EMT.
    Title: Loss of hSef promotes metastasis through upregulation of EMT in prostate cancer.
  9. IL17RD negatively regulates Toll-like receptor (TLR)-induced responses.
    Title: Orphan receptor IL-17RD regulates Toll-like receptor signalling via SEFIR/TIR interactions.
  10. Demonstrate SEF expression in a healthy ovary during folliculogenesis and suggest hormonal regulation of its expression may be an important factor involved in intra-ovarian control mechanisms.
    Title: Expression and regulation of the tumor suppressor, SEF, during folliculogenesis in humans and mice.
Submit: New GeneRIF Correction See all GeneRIFs (30)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ35755, MGC133309, DKFZp434N1928

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables interleukin-17 receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cytokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of epithelial to mesenchymal transition ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in negative regulation of transforming growth factor beta receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
  
located_in Golgi membrane TAS
Traceable Author Statement
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
interleukin-17 receptor D
Names
IL-17 receptor D
IL17Rhom
interleukin-17 receptor-like protein
sef homolog
similar expression to fgf genes

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047158.1 RefSeqGene

    Range
    9965..85336
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001318864.2 → NP_001305793.1  interleukin-17 receptor D isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start site, compared to variant 2. It encodes a shorter isoform (b) which has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AC097358, AF494211, BQ017683, HY005493
    Consensus CDS
    CCDS82790.1
    UniProtKB/TrEMBL
    B4DXM5
    Related
    ENSP00000322250.5, ENST00000320057.9
    Conserved Domains (2) summary
    pfam08357
    Location:212 → 367
    SEFIR; SEFIR domain
    pfam16742
    Location:1 → 25
    IL17R_D_N; N-terminus of interleukin 17 receptor D

  2. NM_017563.5 → NP_060033.3  interleukin-17 receptor D isoform a precursor

    See identical proteins and their annotated locations for NP_060033.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the shorter transcript and encodes the longer isoform a (also known as hSef-a).
    Source sequence(s)
    AC097358, AF458067, AK302045, BQ017683, HY024286
    Consensus CDS
    CCDS2880.2
    UniProtKB/Swiss-Prot
    Q2NKP7, Q58EZ7, Q6RVF4, Q6UWI5, Q8N113, Q8NFM7, Q8NFS0, Q9UFA0
    Related
    ENSP00000296318.7, ENST00000296318.12
    Conserved Domains (2) summary
    pfam08357
    Location:356 → 511
    SEFIR; SEFIR domain
    pfam16742
    Location:48 → 169
    IL17R_D_N; N-terminus of interleukin 17 receptor D

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    57089982..57170317 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047448369.1 → XP_047304325.1  interleukin-17 receptor D isoform X1

  2. XM_005265238.5 → XP_005265295.1  interleukin-17 receptor D isoform X2

    Conserved Domains (2) summary
    pfam08357
    Location:328 → 483
    SEFIR; SEFIR domain
    pfam16742
    Location:20 → 141
    IL17R_D_N; N-terminus of interleukin 17 receptor D

  3. XM_011533849.2 → XP_011532151.2  interleukin-17 receptor D isoform X1

    UniProtKB/TrEMBL
    B4DXM5
    Related
    ENSP00000417516.1, ENST00000463523.5
    Conserved Domains (2) summary
    pfam08357
    Location:212 → 367
    SEFIR; SEFIR domain
    pfam16742
    Location:1 → 25
    IL17R_D_N; N-terminus of interleukin 17 receptor D

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    57130265..57210589 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054346953.1 → XP_054202928.1  interleukin-17 receptor D isoform X2

  2. XM_054346954.1 → XP_054202929.1  interleukin-17 receptor D isoform X1

  3. XM_054346952.1 → XP_054202927.1  interleukin-17 receptor D isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NFM7.3 GenPept UniProtKB/Swiss-Prot:Q8NFM7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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