PPARD peroxisome proliferator activated receptor delta [Homo sapiens (human)] - Gene

Summary

Official Symbol: PPARDprovided by HGNC
Official Full Name: peroxisome proliferator activated receptor deltaprovided by HGNC
Primary source: HGNC:HGNC:9235
See related: Ensembl:ENSG00000112033 MIM:600409
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: FAAR; NUC1; NUCI; NR1C2; NUCII; PPARB
Summary: This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. The encoded protein is thought to function as an integrator of transcriptional repression and nuclear receptor signaling. It may inhibit the ligand-induced transcriptional activity of peroxisome proliferator activated receptors alpha and gamma, though evidence for this effect is inconsistent. Expression of this gene in colorectal cancer cells may be variable but is typically relatively low. Knockout studies in mice suggested a role for this protein in myelination of the corpus callosum, lipid metabolism, differentiation, and epidermal cell proliferation. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. [provided by RefSeq, Aug 2017]
Expression: Ubiquitous expression in placenta (RPKM 13.1), thyroid (RPKM 10.8) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 6p21.31

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
109.20210514	current	GRCh38.p13 (GCF_000001405.39)	6	NC_000006.12 (35342558..35428180)
105.20201022	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (35310335..35395955)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Single Nucleotide Polymorphisms in PPARD Associated with Systemic Lupus Erythematosus in Chinese Populations.
Title: Single Nucleotide Polymorphisms in PPARD Associated with Systemic Lupus Erythematosus in Chinese Populations.
Wnt/beta-catenin Pathway-Mediated PPARdelta Expression during Embryonic Development Differentiation and Disease.
Title: Wnt/β-catenin Pathway-Mediated PPARδ Expression during Embryonic Development Differentiation and Disease.
The NFkappaB Antagonist CDGSH Iron-Sulfur Domain 2 Is a Promising Target for the Treatment of Neurodegenerative Diseases.
Title: The NFκB Antagonist CDGSH Iron-Sulfur Domain 2 Is a Promising Target for the Treatment of Neurodegenerative Diseases.
Identification of host variants associated with overall survival of esophageal cancer patients receiving platinum-based therapy.
Title: Identification of host variants associated with overall survival of esophageal cancer patients receiving platinum-based therapy.
Pro12Ala PPAR-gamma2 and +294T/C PPAR-delta Polymorphisms and Association with Metabolic Traits in Teenagers from Northern Mexico.
Title: Pro12Ala PPAR-γ2 and +294T/C PPAR-δ Polymorphisms and Association with Metabolic Traits in Teenagers from Northern Mexico.
The function of peroxisome proliferator-activated receptors PPAR-gamma and PPAR-delta in Mycobacterium leprae-induced foam cell formation in host macrophages.
Title: The function of peroxisome proliferator-activated receptors PPAR-γ and PPAR-δ in Mycobacterium leprae-induced foam cell formation in host macrophages.
Aspirin Improves Nonalcoholic Fatty Liver Disease and Atherosclerosis through Regulation of the PPARdelta-AMPK-PGC-1alpha Pathway in Dyslipidemic Conditions.
Title: Aspirin Improves Nonalcoholic Fatty Liver Disease and Atherosclerosis through Regulation of the PPARδ-AMPK-PGC-1α Pathway in Dyslipidemic Conditions.
PPARdelta is a regulator of autophagy by its phosphorylation.
Title: PPARδ is a regulator of autophagy by its phosphorylation.
The Impact of PPARD and PPARG Polymorphisms on Glioma Risk and Prognosis.
Title: The Impact of PPARD and PPARG Polymorphisms on Glioma Risk and Prognosis.
PPARdelta agonist prevents endothelial dysfunction via induction of dihydrofolate reductase gene and activation of tetrahydrobiopterin salvage pathway.
Title: PPARδ agonist prevents endothelial dysfunction via induction of dihydrofolate reductase gene and activation of tetrahydrobiopterin salvage pathway.

Submit: New GeneRIF Correction See all GeneRIFs (254)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. GeneReviews: Not available
Genomewide pharmacogenomic study of metabolic side effects to antipsychotic drugs. GeneReviews: Not available
Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry. GeneReviews: Not available
Novel susceptibility genes associated with diabetic cataract in a Taiwanese population. GeneReviews: Not available

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Vpr	vpr	HIV-1 Vpr regulates mitochondrial respiration and enhances the activity of hydroxyacyl-CoA dehydrogenase (HADH) through PPARbeta/delta	PubMed
	vpr	HIV-1 Vpr enhances PPARbeta/delta-induced PDK4, carnitine palmitoyltransferase I (CPT1), and acetyl-coenzyme A acyltransferase 2 (ACAA2) mRNA expression in cells	PubMed
	vpr	HIV-1 Vpr enhances PPARbeta/delta agonist GW501516-induced pyruvate dehydrogenase kinase 4 (PDK4) protein expression and phosphorylation of pyruvate dehydrogenase alpha 1 (PDHE1alpha) at serine 293 in cells	PubMed
	vpr	HIV-1 Vpr physically interacts with the LXXLL motif (residues 64-68) of PPARbeta/delta in vivo and in vitro and enhances PPARbeta/delta-induced transcription activity	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC33205P2 (e-PCR)
- UniSTS:273157

AL031219 (e-PCR)
- UniSTS:60934

RH123251 (e-PCR)
- UniSTS:138016

SHGC-80622 (e-PCR)
- UniSTS:102191

PMC156606P1 (e-PCR)
- UniSTS:271408

D8S2279 (e-PCR)
- UniSTS:473907

MARC_45796-45797:1102976080:1 (e-PCR)
- UniSTS:471629

MARC_45802-45803:1103063697:1 (e-PCR)
- UniSTS:471632

STS-L07592 (e-PCR)
- UniSTS:20056

D11S3114 (e-PCR)
- UniSTS:152207

RH120615 (e-PCR)
- UniSTS:132556

PMC137182P9 (e-PCR)
- UniSTS:270830

D6S1611 (e-PCR)
- UniSTS:44279

Homology

Homologs of the PPARD gene: The PPARD gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 357 organisms have orthologs with human gene PPARD
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	NAS Non-traceable Author Statement more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISA Inferred from Sequence Alignment more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISS Inferred from Sequence or Structural Similarity more info
enables NF-kappaB binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables drug binding	IDA Inferred from Direct Assay more info	PubMed
enables linoleic acid binding	IDA Inferred from Direct Assay more info	PubMed
enables lipid binding	IDA Inferred from Direct Assay more info	PubMed
enables nuclear receptor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables nuclear receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables steroid hormone receptor activity	TAS Traceable Author Statement more info	PubMed
enables transcription coactivator binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in adipose tissue development	IEA Inferred from Electronic Annotation more info
involved_in apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon ensheathment	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell-substrate adhesion	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hypoxia	IEA Inferred from Electronic Annotation more info
involved_in cellular response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
involved_in cholesterol metabolic process	TAS Traceable Author Statement more info	PubMed
involved_in decidualization	TAS Traceable Author Statement more info	PubMed
involved_in embryo implantation	TAS Traceable Author Statement more info	PubMed
involved_in fatty acid beta-oxidation	ISS Inferred from Sequence or Structural Similarity more info
involved_in fatty acid beta-oxidation	TAS Traceable Author Statement more info	PubMed
involved_in fatty acid catabolic process	TAS Traceable Author Statement more info	PubMed
involved_in fatty acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in fatty acid transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in generation of precursor metabolites and energy	TAS Traceable Author Statement more info	PubMed
involved_in glucose metabolic process	NAS Non-traceable Author Statement more info	PubMed
involved_in glucose transmembrane transport	NAS Non-traceable Author Statement more info	PubMed
involved_in heart development	IEA Inferred from Electronic Annotation more info
involved_in hormone-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in intracellular receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in keratinocyte migration	IEA Inferred from Electronic Annotation more info
involved_in keratinocyte proliferation	IEA Inferred from Electronic Annotation more info
involved_in lipid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell growth	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cholesterol storage	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in negative regulation of collagen biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of epithelial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of inflammatory response	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in negative regulation of myoblast differentiation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of pri-miRNA transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of smooth muscle cell migration	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of smooth muscle cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transcription, DNA-templated	ISS Inferred from Sequence or Structural Similarity more info
involved_in phospholipid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of epidermis development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of fat cell differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of fatty acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in positive regulation of fatty acid oxidation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of myoblast proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of phosphatidylinositol 3-kinase signaling	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of skeletal muscle tissue regeneration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in positive regulation of transcription, DNA-templated	IDA Inferred from Direct Assay more info	PubMed
involved_in proteoglycan metabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of lipid metabolic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in regulation of skeletal muscle satellite cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	TAS Traceable Author Statement more info	PubMed
involved_in response to activity	IEA Inferred from Electronic Annotation more info
involved_in response to glucose	IEA Inferred from Electronic Annotation more info
involved_in response to lipid	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in response to vitamin A	IEA Inferred from Electronic Annotation more info
involved_in steroid hormone mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in vasodilation	IEA Inferred from Electronic Annotation more info
involved_in vitamin A metabolic process	IEA Inferred from Electronic Annotation more info
involved_in wound healing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chromatin	ISA Inferred from Sequence Alignment more info
located_in chromatin	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: peroxisome proliferator-activated receptor delta

Names: PPAR-beta; PPAR-delta; PPARD/MYO1D fusion; nuclear hormone receptor 1; nuclear receptor subfamily 1 group C member 2; peroxisome proliferator-activated receptor beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012345.2 RefSeqGene

Range

5001..90621

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001171818.2 → NP_001165289.1 peroxisome proliferator-activated receptor delta isoform 1

See identical proteins and their annotated locations for NP_001165289.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Both variants 1 and 3 encode the same isoform (1).

Source sequence(s)

AB099507, AK122614, AL022721, BE503383, DA192442

Consensus CDS

CCDS4803.1

UniProtKB/Swiss-Prot

Q03181

UniProtKB/TrEMBL

A0A024RCW6

Related

ENSP00000310928.4, ENST00000311565.4

Conserved Domains (2) summary

cd06932
Location:173 → 440

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:73 → 156

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
NM_001171819.2 → NP_001165290.1 peroxisome proliferator-activated receptor delta isoform 3

See identical proteins and their annotated locations for NP_001165290.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.

Source sequence(s)

AK122614, AK296425, AL022721, BE503383, DA192442

Consensus CDS

CCDS54994.1

UniProtKB/Swiss-Prot

Q03181

Related

ENSP00000414372.2, ENST00000448077.6

Conserved Domains (2) summary

cd06932
Location:134 → 401

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:34 → 117

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
NM_001171820.2 → NP_001165291.1 peroxisome proliferator-activated receptor delta isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (5) lacks two in-frame exons in the coding region, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.

Source sequence(s)

AK122614, AK304878, AL022721, BE503383, DA192442

Consensus CDS

CCDS54995.1

UniProtKB/Swiss-Prot

Q03181

Related

ENSP00000413314.2, ENST00000418635.6

Conserved Domains (2) summary

cd06932
Location:75 → 342

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cl02596
Location:41 → 58

NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
NM_006238.5 → NP_006229.1 peroxisome proliferator-activated receptor delta isoform 1

See identical proteins and their annotated locations for NP_006229.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1). Both variants 1 and 3 encode the same isoform (1).

Source sequence(s)

AK122614, BE503383, DA192442

Consensus CDS

CCDS4803.1

UniProtKB/Swiss-Prot

Q03181

UniProtKB/TrEMBL

A0A024RCW6

Related

ENSP00000353916.3, ENST00000360694.8

Conserved Domains (2) summary

cd06932
Location:173 → 440

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:73 → 156

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
NM_177435.3 → NP_803184.1 peroxisome proliferator-activated receptor delta isoform 2

See identical proteins and their annotated locations for NP_803184.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate exon in the 3' coding region and 3'UTR. It encodes isoform 2, which is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AL022721, BC002715, CN332566, DA192442, DA476590

Consensus CDS

CCDS4804.1

UniProtKB/Swiss-Prot

Q03181

UniProtKB/TrEMBL

F1D8S7

Related

ENSP00000337063.2, ENST00000337400.6

Conserved Domains (2) summary

cd06965
Location:73 → 156

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

cl11397
Location:173 → 359

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

NC_000006.12 Reference GRCh38.p13 Primary Assembly

Range

35342558..35428180

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017010974.1 → XP_016866463.1 peroxisome proliferator-activated receptor delta isoform X1

UniProtKB/Swiss-Prot

Q03181

UniProtKB/TrEMBL

A0A024RCW6

Conserved Domains (2) summary

cd06932
Location:173 → 440

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:73 → 156

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
XM_005249193.1 → XP_005249250.1 peroxisome proliferator-activated receptor delta isoform X1

See identical proteins and their annotated locations for XP_005249250.1

UniProtKB/Swiss-Prot

Q03181

UniProtKB/TrEMBL

A0A024RCW6

Conserved Domains (2) summary

cd06932
Location:173 → 440

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:73 → 156

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
XM_011514707.1 → XP_011513009.1 peroxisome proliferator-activated receptor delta isoform X1

See identical proteins and their annotated locations for XP_011513009.1

UniProtKB/Swiss-Prot

Q03181

UniProtKB/TrEMBL

A0A024RCW6

Conserved Domains (2) summary

cd06932
Location:173 → 440

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:73 → 156

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
XM_017010972.1 → XP_016866461.1 peroxisome proliferator-activated receptor delta isoform X1

UniProtKB/Swiss-Prot

Q03181

UniProtKB/TrEMBL

A0A024RCW6

Conserved Domains (2) summary

cd06932
Location:173 → 440

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:73 → 156

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
XM_006715120.1 → XP_006715183.1 peroxisome proliferator-activated receptor delta isoform X1

See identical proteins and their annotated locations for XP_006715183.1

UniProtKB/Swiss-Prot

Q03181

UniProtKB/TrEMBL

A0A024RCW6

Conserved Domains (2) summary

cd06932
Location:173 → 440

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:73 → 156

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
XM_011514710.1 → XP_011513012.1 peroxisome proliferator-activated receptor delta isoform X1

See identical proteins and their annotated locations for XP_011513012.1

UniProtKB/Swiss-Prot

Q03181

UniProtKB/TrEMBL

A0A024RCW6

Conserved Domains (2) summary

cd06932
Location:173 → 440

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:73 → 156

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
XM_017010973.1 → XP_016866462.1 peroxisome proliferator-activated receptor delta isoform X1

UniProtKB/Swiss-Prot

Q03181

UniProtKB/TrEMBL

A0A024RCW6

Conserved Domains (2) summary

cd06932
Location:173 → 440

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:73 → 156

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
XM_006715123.1 → XP_006715186.1 peroxisome proliferator-activated receptor delta isoform X1

See identical proteins and their annotated locations for XP_006715186.1

UniProtKB/Swiss-Prot

Q03181

UniProtKB/TrEMBL

A0A024RCW6

Conserved Domains (2) summary

cd06932
Location:173 → 440

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:73 → 156

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
XM_024446474.1 → XP_024302242.1 peroxisome proliferator-activated receptor delta isoform X2

Conserved Domains (2) summary

cd06965
Location:73 → 156

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

cl11397
Location:173 → 359

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators