PPARD peroxisome proliferator activated receptor delta [Homo sapiens (human)] - Gene

Summary

Official Symbol: PPARDprovided by HGNC
Official Full Name: peroxisome proliferator activated receptor deltaprovided by HGNC
Primary source: HGNC:HGNC:9235
See related: Ensembl:ENSG00000112033 MIM:600409; Vega:OTTHUMG00000014567
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: FAAR; NUC1; NUCI; NR1C2; NUCII; PPARB
Summary: This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. The encoded protein is thought to function as an integrator of transcriptional repression and nuclear receptor signaling. It may inhibit the ligand-induced transcriptional activity of peroxisome proliferator activated receptors alpha and gamma, though evidence for this effect is inconsistent. Expression of this gene in colorectal cancer cells may be variable but is typically relatively low. Knockout studies in mice suggested a role for this protein in myelination of the corpus callosum, lipid metabolism, differentiation, and epidermal cell proliferation. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. [provided by RefSeq, Aug 2017]
Expression: Ubiquitous expression in placenta (RPKM 13.1), thyroid (RPKM 10.8) and 25 other tissues See more
Orthologs: mouse all

Genomic context

Location:: 6p21.31

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
109	current	GRCh38.p12 (GCF_000001405.38)	6	NC_000006.12 (35342558..35428191)
105	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (35310335..35395968)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

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GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

PPARD rs7770619 is a novel candidate variant for impaired fasting glucose and type 2 diabetes and shows association with malondialdehyde levels.
Title: PPARD rs7770619 polymorphism in a Korean population: Association with plasma malondialdehyde and impaired fasting glucose or newly diagnosed type 2 diabetes.
The negative responders for aerobic training are carriers of the PPARD rs2267668 G allele. The best responders to aerobic training are PPARD rs1053049 TT and rs2267668 AA.
Title: The Role of Peroxisome Proliferator-Activated Receptors and Their Transcriptional Coactivators Gene Variations in Human Trainability: A Systematic Review.
The current results suggest that A/A carriers of PPAR-delta SNP (rs2267668) may enjoy fewer beneficial effects of exercise-centered lifestyle intervention on anthropometric indices and blood measurements.
Title: Influence of Single-Nucleotide Polymorphisms in PPAR-δ, PPAR-γ, and PRKAA2 on the Changes in Anthropometric Indices and Blood Measurements through Exercise-Centered Lifestyle Intervention in Japanese Middle-Aged Men.
Polymorphism of PPARD is associated with late onset of type 2 diabetes mellitus.
Title: Association of polymorphisms of peroxisome proliferator activated receptors in early and late onset of type 2 diabetes mellitus.
findings suggest that PPARdelta conditions CLL cells to survive in harsh microenvironmental conditions by reducing oxidative stress and increasing metabolic efficiency.
Title: PPAR-delta promotes survival of chronic lymphocytic leukemia cells in energetically unfavorable conditions.
Here, theauthors describe a novel PPARbeta/delta-dependent molecular cascade involving TGFbeta1 and miR-21-3p, which is activated in the epidermis in response to UV exposure.
Title: Identification of a novel PPARβ/δ/miR-21-3p axis in UV-induced skin inflammation.
findings identified previously unrecognized role of IP-PPARdelta signal transduction pathway in the production of sAPPalpha in cerebral microvasculature.
Title: Role of prostacyclin signaling in endothelial production of soluble amyloid precursor protein-α in cerebral microvessels.
the metabolic events, controlled by PPARs, occurring during neuronal precursor differentiation, the glucose and lipid metabolism was investigated.
Title: Roles of PPAR transcription factors in the energetic metabolic switch occurring during adult neurogenesis.
PPAR-delta activation prevents in-stent restenosis and stent thrombosis.
Title: Activation of Peroxisome Proliferator-Activated Receptor-δ as Novel Therapeutic Strategy to Prevent In-Stent Restenosis and Stent Thrombosis.
findings identify LPCAT3 as a direct PPARdelta target gene and suggest a novel function of PPARdelta in regulation of phospholipid metabolism through LPCAT3.
Title: Identification of Hepatic Lysophosphatidylcholine Acyltransferase 3 as a Novel Target Gene Regulated by Peroxisome Proliferator-activated Receptor δ.

Submit: New GeneRIF Correction See all GeneRIFs (227)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

NHGRI GWAS Catalog

Description
Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Genomewide pharmacogenomic study of metabolic side effects to antipsychotic drugs. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Novel susceptibility genes associated with diabetic cataract in a Taiwanese population. NHGRI GWA Catalog NHGRI GWA CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Vpr	vpr	HIV-1 Vpr regulates mitochondrial respiration and enhances the activity of hydroxyacyl-CoA dehydrogenase (HADH) through PPARbeta/delta	PubMed
	vpr	HIV-1 Vpr enhances PPARbeta/delta-induced PDK4, carnitine palmitoyltransferase I (CPT1), and acetyl-coenzyme A acyltransferase 2 (ACAA2) mRNA expression in cells	PubMed
	vpr	HIV-1 Vpr enhances PPARbeta/delta agonist GW501516-induced pyruvate dehydrogenase kinase 4 (PDK4) protein expression and phosphorylation of pyruvate dehydrogenase alpha 1 (PDHE1alpha) at serine 293 in cells	PubMed
	vpr	HIV-1 Vpr physically interacts with the LXXLL motif (residues 64-68) of PPARbeta/delta in vivo and in vitro and enhances PPARbeta/delta-induced transcription activity	PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

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Acute myeloid leukemia, organism-specific biosystem (from KEGG)
Acute myeloid leukemia, organism-specific biosystemAcute myeloid leukemia (AML) is a disease that is characterized by uncontrolled proliferation of clonal neoplastic cells and accumulation in the bone marrow of blasts with an impaired differentiation...
Acute myeloid leukemia, conserved biosystem (from KEGG)
Acute myeloid leukemia, conserved biosystemAcute myeloid leukemia (AML) is a disease that is characterized by uncontrolled proliferation of clonal neoplastic cells and accumulation in the bone marrow of blasts with an impaired differentiation...
Adipogenesis, organism-specific biosystem (from WikiPathways)
Adipogenesis, organism-specific biosystemThe different classess of factors involved in adipogenesis are shown. Adipogenesis is the process by which fat cells differentiate from predadipocytes to adipocytes (fat cells). Adipose tissue, compo...
Ectoderm Differentiation, organism-specific biosystem (from WikiPathways)
Ectoderm Differentiation, organism-specific biosystemModel depicting ectoderm specification based on the literature and highly enriched gene expression profiles via comparison across dozens of independent induced and embryonic pluripotent stem cell lin...
Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem (from REACTOME)
Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystemThe reactions involved in the metabolism of fatty acids and of the triacylglycerols and ketone bodies derived from them form a closely interrelated, coordinately regulated module that plays a central...
Gene Expression, organism-specific biosystem (from REACTOME)
Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
Import of palmitoyl-CoA into the mitochondrial matrix, organism-specific biosystem (from REACTOME)
Import of palmitoyl-CoA into the mitochondrial matrix, organism-specific biosystemThe mitochondrial carnitine system catalyzes the transport of long-chain fatty acids into the mitochondrial matrix where they undergo beta oxidation. This transport system consists of the malonyl-Co...
Metabolism, organism-specific biosystem (from REACTOME)
Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
NRF2 pathway, organism-specific biosystem (from WikiPathways)
NRF2 pathway, organism-specific biosystemNRF2 is part of a group of transcription factors called nuclear receptors. It is activated under oxidative stress conditions and subsequently activates several antioxidative genes and proteins.
Nuclear Receptor transcription pathway, organism-specific biosystem (from REACTOME)
Nuclear Receptor transcription pathway, organism-specific biosystemA classic example of bifunctional transcription factors is the family of Nuclear Receptor (NR) proteins. These are DNA-binding transcription factors that bind certain hormones, vitamins, and other s...
Nuclear Receptors, organism-specific biosystem (from WikiPathways)
Nuclear Receptors, organism-specific biosystemNuclear receptors are a class of proteins found within the interior of cells that are responsible for sensing the presence of steroid and thyroid hormones and certain other molecules. In response, th...
Nuclear Receptors in Lipid Metabolism and Toxicity, organism-specific biosystem (from WikiPathways)
Nuclear Receptors in Lipid Metabolism and Toxicity, organism-specific biosystemNuclear receptors are transcription factors that are activated upon binding to its ligands. Initially, they had been classified as classic endocrine nuclear hormone receptors and orphan receptors. Ho...
PPAR signaling pathway, organism-specific biosystem (from KEGG)
PPAR signaling pathway, organism-specific biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
PPAR signaling pathway, conserved biosystem (from KEGG)
PPAR signaling pathway, conserved biosystemPeroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) s...
Pathways in cancer, organism-specific biosystem (from KEGG)
Pathways in cancer, organism-specific biosystem
Pathways in cancer
Presenilin action in Notch and Wnt signaling, organism-specific biosystem (from Pathway Interaction Database)
Presenilin action in Notch and Wnt signaling, organism-specific biosystem
Presenilin action in Notch and Wnt signaling
Pyruvate metabolism, organism-specific biosystem (from REACTOME)
Pyruvate metabolism, organism-specific biosystemPyruvate sits at an intersection of key pathways of energy metabolism. It is the end product of glycolysis and the starting point for gluconeogenesis, and can be generated by transamination of alanin...
Pyruvate metabolism and Citric Acid (TCA) cycle, organism-specific biosystem (from REACTOME)
Pyruvate metabolism and Citric Acid (TCA) cycle, organism-specific biosystemPyruvate metabolism and the citric acid (TCA) cycle together link the processes of energy metabolism in a human cell with one another and with key biosynthetic reactions. Pyruvate, derived from the r...
Regulation of pyruvate dehydrogenase (PDH) complex, organism-specific biosystem (from REACTOME)
Regulation of pyruvate dehydrogenase (PDH) complex, organism-specific biosystemThe mitochondrial pyruvate dehydrogenase (PDH) complex catalyzes the oxidative decarboxylation of pyruvate, linking glycolysis to the tricarboxylic acid cycle and fatty acid synthesis. PDH inactivati...
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
Signaling by Retinoic Acid, organism-specific biosystem (from REACTOME)
Signaling by Retinoic Acid, organism-specific biosystemVitamin A (retinol) can be metabolised into active retinoid metabolites that function either as a chromophore in vision or in regulating gene expression transcriptionally and post-transcriptionally. ...
The citric acid (TCA) cycle and respiratory electron transport, organism-specific biosystem (from REACTOME)
The citric acid (TCA) cycle and respiratory electron transport, organism-specific biosystemThe metabolism of pyruvate provides one source of acetyl-CoA which enters the citric acid (TCA, tricarboxylic acid) cycle to generate energy and the reducing equivalent NADH. These reducing equivalen...
Wnt Signaling Pathway and Pluripotency, organism-specific biosystem (from WikiPathways)
Wnt Signaling Pathway and Pluripotency, organism-specific biosystemThis pathway was adapted from several resources and is designed to provide a theoretical frame-work for examining Wnt signaling and interacting components in the context of embryonic stem-cell plurip...
Wnt signaling pathway, organism-specific biosystem (from KEGG)
Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
Wnt signaling pathway, conserved biosystem (from KEGG)
Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
Wnt/beta-catenin Signaling Pathway in Leukemia, organism-specific biosystem (from WikiPathways)
Wnt/beta-catenin Signaling Pathway in Leukemia, organism-specific biosystemThe Wnt/Beta-catenin pathway mediates the transcription of proteins important for maintenance and growth of hematopoietic stem cells. The inhibition of Wnt leads to protein degradation through Beta-C...

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC33205P2 (e-PCR)
- UniSTS:273157

AL031219 (e-PCR)
- UniSTS:60934

RH123251 (e-PCR)
- UniSTS:138016

SHGC-80622 (e-PCR)
- UniSTS:102191

PMC156606P1 (e-PCR)
- UniSTS:271408

D8S2279 (e-PCR)
- UniSTS:473907

MARC_45796-45797:1102976080:1 (e-PCR)
- UniSTS:471629

MARC_45802-45803:1103063697:1 (e-PCR)
- UniSTS:471632

STS-L07592 (e-PCR)
- UniSTS:20056

D11S3114 (e-PCR)
- UniSTS:152207

RH120615 (e-PCR)
- UniSTS:132556

PMC137182P9 (e-PCR)
- UniSTS:270830

D6S1611 (e-PCR)
- UniSTS:44279

Homology

Homologs of the PPARD gene: The PPARD gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 241 organisms have orthologs with human gene PPARD
The Hierarchical Catalog of Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
DNA binding	ISS Inferred from Sequence or Structural Similarity more info
DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
DNA-binding transcription factor activity	NAS Non-traceable Author Statement more info	PubMed
DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info	PubMed
DNA-binding transcription factor activity, RNA polymerase II-specific	ISA Inferred from Sequence Alignment more info
DNA-binding transcription factor activity, RNA polymerase II-specific	ISM Inferred from Sequence Model more info	PubMed
DNA-binding transcription factor activity, RNA polymerase II-specific	NAS Non-traceable Author Statement more info	PubMed
DNA-binding transcription repressor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info	PubMed
DNA-binding transcription repressor activity, RNA polymerase II-specific	ISS Inferred from Sequence or Structural Similarity more info
NF-kappaB binding	IEA Inferred from Electronic Annotation more info
RNA polymerase II regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
RNA polymerase II repressing transcription factor binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
drug binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
drug binding	IDA Inferred from Direct Assay more info	PubMed
fatty acid binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
linoleic acid binding	IDA Inferred from Direct Assay more info	PubMed
lipid binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
lipid binding	IDA Inferred from Direct Assay more info	PubMed
nuclear receptor activity	IDA Inferred from Direct Assay more info	PubMed
nuclear receptor transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info	PubMed
signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
steroid hormone receptor activity	IEA Inferred from Electronic Annotation more info
transcription factor binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
adipose tissue development	IEA Inferred from Electronic Annotation more info
apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
axon ensheathment	ISS Inferred from Sequence or Structural Similarity more info
cell differentiation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
cell proliferation	TAS Traceable Author Statement more info	PubMed
cell-substrate adhesion	IEA Inferred from Electronic Annotation more info
cellular response to hypoxia	IEA Inferred from Electronic Annotation more info
cellular response to lipopolysaccharide	IEA Inferred from Electronic Annotation more info
cholesterol metabolic process	TAS Traceable Author Statement more info	PubMed
decidualization	TAS Traceable Author Statement more info	PubMed
embryo implantation	TAS Traceable Author Statement more info	PubMed
fatty acid beta-oxidation	ISS Inferred from Sequence or Structural Similarity more info
fatty acid beta-oxidation	TAS Traceable Author Statement more info	PubMed
fatty acid catabolic process	TAS Traceable Author Statement more info	PubMed
fatty acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
fatty acid transport	ISS Inferred from Sequence or Structural Similarity more info
generation of precursor metabolites and energy	TAS Traceable Author Statement more info	PubMed
glucose metabolic process	NAS Non-traceable Author Statement more info	PubMed
glucose transmembrane transport	NAS Non-traceable Author Statement more info	PubMed
heart development	IEA Inferred from Electronic Annotation more info
hormone-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
intracellular receptor signaling pathway	IEA Inferred from Electronic Annotation more info
keratinocyte migration	IEA Inferred from Electronic Annotation more info
keratinocyte proliferation	IEA Inferred from Electronic Annotation more info
lipid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
mRNA transcription	IEA Inferred from Electronic Annotation more info
multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info	PubMed
negative regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
negative regulation of cell growth	IEA Inferred from Electronic Annotation more info
negative regulation of cholesterol storage	IBA Inferred from Biological aspect of Ancestor more info	PubMed
negative regulation of collagen biosynthetic process	IEA Inferred from Electronic Annotation more info
negative regulation of epithelial cell proliferation	IEA Inferred from Electronic Annotation more info
negative regulation of inflammatory response	IBA Inferred from Biological aspect of Ancestor more info	PubMed
negative regulation of myoblast differentiation	IEA Inferred from Electronic Annotation more info
negative regulation of pri-miRNA transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of smooth muscle cell migration	IEA Inferred from Electronic Annotation more info
negative regulation of smooth muscle cell proliferation	IEA Inferred from Electronic Annotation more info
negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info	PubMed
negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of transcription, DNA-templated	IBA Inferred from Biological aspect of Ancestor more info	PubMed
negative regulation of transcription, DNA-templated	ISS Inferred from Sequence or Structural Similarity more info
phospholipid biosynthetic process	IEA Inferred from Electronic Annotation more info
positive regulation of blood vessel diameter	IEA Inferred from Electronic Annotation more info
positive regulation of epidermis development	IEA Inferred from Electronic Annotation more info
positive regulation of fat cell differentiation	NAS Non-traceable Author Statement more info	PubMed
positive regulation of insulin secretion	IEA Inferred from Electronic Annotation more info
positive regulation of myoblast proliferation	IEA Inferred from Electronic Annotation more info
positive regulation of phosphatidylinositol 3-kinase signaling	IEA Inferred from Electronic Annotation more info
positive regulation of skeletal muscle tissue regeneration	IEA Inferred from Electronic Annotation more info
positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info	PubMed
positive regulation of transcription, DNA-templated	IDA Inferred from Direct Assay more info	PubMed
proteoglycan metabolic process	IEA Inferred from Electronic Annotation more info
regulation of lipid metabolic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
regulation of skeletal muscle satellite cell proliferation	IEA Inferred from Electronic Annotation more info
regulation of transcription by RNA polymerase II	TAS Traceable Author Statement more info	PubMed
response to activity	IEA Inferred from Electronic Annotation more info
response to glucose	IEA Inferred from Electronic Annotation more info
response to lipid	IBA Inferred from Biological aspect of Ancestor more info	PubMed
response to vitamin A	IEA Inferred from Electronic Annotation more info
steroid hormone mediated signaling pathway	IEA Inferred from Electronic Annotation more info
transcription initiation from RNA polymerase II promoter	TAS Traceable Author Statement more info
vitamin A metabolic process	IEA Inferred from Electronic Annotation more info
wound healing	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
RNA polymerase II transcription factor complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
nuclear chromatin	ISS Inferred from Sequence or Structural Similarity more info
nucleoplasm	TAS Traceable Author Statement more info
nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
nucleus	NAS Non-traceable Author Statement more info	PubMed

General protein information

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Preferred Names: peroxisome proliferator-activated receptor delta

Names: PPAR-beta; PPAR-delta; PPARD/MYO1D fusion; nuclear hormone receptor 1; nuclear receptor subfamily 1 group C member 2; peroxisome proliferator-activated receptor beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012345.1 RefSeqGene

Range

5001..90634

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001171818.1 → NP_001165289.1 peroxisome proliferator-activated receptor delta isoform 1

See identical proteins and their annotated locations for NP_001165289.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Both variants 1 and 3 encode the same isoform (1).

Source sequence(s)

AB099507, AK122614, AL022721, BE503383, DA192442

Consensus CDS

CCDS4803.1

UniProtKB/Swiss-Prot

Q03181

UniProtKB/TrEMBL

A0A024RCW6

Related

ENSP00000310928.4, OTTHUMP00000016256, ENST00000311565.4, OTTHUMT00000040288

Conserved Domains (2) summary

cd06932
Location:173 → 440

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:73 → 156

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
NM_001171819.1 → NP_001165290.1 peroxisome proliferator-activated receptor delta isoform 3

See identical proteins and their annotated locations for NP_001165290.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) has a distinct N-terminus and is shorter than isoform 1.

Source sequence(s)

AK122614, AK296425, AL022721, BE503383, DA192442

Consensus CDS

CCDS54994.1

UniProtKB/Swiss-Prot

Q03181

Related

ENSP00000414372.2, ENST00000448077.6

Conserved Domains (2) summary

cd06932
Location:134 → 401

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:34 → 117

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
NM_001171820.1 → NP_001165291.1 peroxisome proliferator-activated receptor delta isoform 4

Status: REVIEWED

Description

Transcript Variant: This variant (5) lacks two in-frame exons in the coding region, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.

Source sequence(s)

AK122614, AK304878, AL022721, BE503383, DA192442

Consensus CDS

CCDS54995.1

UniProtKB/Swiss-Prot

Q03181

Related

ENSP00000413314.2, ENST00000418635.6

Conserved Domains (2) summary

cd06932
Location:75 → 342

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cl02596
Location:41 → 58

NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
NM_006238.4 → NP_006229.1 peroxisome proliferator-activated receptor delta isoform 1

See identical proteins and their annotated locations for NP_006229.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1). Both variants 1 and 3 encode the same isoform (1).

Source sequence(s)

AK122614, BE503383, DA192442

Consensus CDS

CCDS4803.1

UniProtKB/Swiss-Prot

Q03181

UniProtKB/TrEMBL

A0A024RCW6

Related

ENSP00000353916.3, ENST00000360694.7

Conserved Domains (2) summary

cd06932
Location:173 → 440

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:73 → 156

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
NM_177435.2 → NP_803184.1 peroxisome proliferator-activated receptor delta isoform 2

See identical proteins and their annotated locations for NP_803184.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate exon in the 3' coding region and 3'UTR. It encodes isoform 2, which is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

BC002715, CN332566, DA192442, DA476590

Consensus CDS

CCDS4804.1

UniProtKB/Swiss-Prot

Q03181

UniProtKB/TrEMBL

F1D8S7

Related

ENSP00000337063.2, OTTHUMP00000016257, ENST00000337400.6, OTTHUMT00000040289

Conserved Domains (2) summary

cd06965
Location:73 → 156

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

cl11397
Location:173 → 359

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

NC_000006.12 Reference GRCh38.p12 Primary Assembly

Range

35342558..35428191

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017010974.1 → XP_016866463.1 peroxisome proliferator-activated receptor delta isoform X1

UniProtKB/Swiss-Prot

Q03181

UniProtKB/TrEMBL

A0A024RCW6

Conserved Domains (2) summary

cd06932
Location:173 → 440

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:73 → 156

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
XM_005249193.1 → XP_005249250.1 peroxisome proliferator-activated receptor delta isoform X1

See identical proteins and their annotated locations for XP_005249250.1

UniProtKB/Swiss-Prot

Q03181

UniProtKB/TrEMBL

A0A024RCW6

Conserved Domains (2) summary

cd06932
Location:173 → 440

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:73 → 156

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
XM_011514707.1 → XP_011513009.1 peroxisome proliferator-activated receptor delta isoform X1

See identical proteins and their annotated locations for XP_011513009.1

UniProtKB/Swiss-Prot

Q03181

UniProtKB/TrEMBL

A0A024RCW6

Conserved Domains (2) summary

cd06932
Location:173 → 440

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:73 → 156

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
XM_017010972.1 → XP_016866461.1 peroxisome proliferator-activated receptor delta isoform X1

UniProtKB/Swiss-Prot

Q03181

UniProtKB/TrEMBL

A0A024RCW6

Conserved Domains (2) summary

cd06932
Location:173 → 440

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:73 → 156

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
XM_006715120.1 → XP_006715183.1 peroxisome proliferator-activated receptor delta isoform X1

See identical proteins and their annotated locations for XP_006715183.1

UniProtKB/Swiss-Prot

Q03181

UniProtKB/TrEMBL

A0A024RCW6

Conserved Domains (2) summary

cd06932
Location:173 → 440

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:73 → 156

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
XM_011514710.1 → XP_011513012.1 peroxisome proliferator-activated receptor delta isoform X1

See identical proteins and their annotated locations for XP_011513012.1

UniProtKB/Swiss-Prot

Q03181

UniProtKB/TrEMBL

A0A024RCW6

Conserved Domains (2) summary

cd06932
Location:173 → 440

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:73 → 156

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
XM_017010973.1 → XP_016866462.1 peroxisome proliferator-activated receptor delta isoform X1

UniProtKB/Swiss-Prot

Q03181

UniProtKB/TrEMBL

A0A024RCW6

Conserved Domains (2) summary

cd06932
Location:173 → 440

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:73 → 156

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
XM_006715123.1 → XP_006715186.1 peroxisome proliferator-activated receptor delta isoform X1

See identical proteins and their annotated locations for XP_006715186.1

UniProtKB/Swiss-Prot

Q03181

UniProtKB/TrEMBL

A0A024RCW6

Conserved Domains (2) summary

cd06932
Location:173 → 440

NR_LBD_PPAR; The ligand binding domain of peroxisome proliferator-activated receptors

cd06965
Location:73 → 156

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers
XM_024446474.1 → XP_024302242.1 peroxisome proliferator-activated receptor delta isoform X2

Conserved Domains (2) summary

cd06965
Location:73 → 156

NR_DBD_Ppar; DNA-binding domain of peroxisome proliferator-activated receptors (PPAR) is composed of two C4-type zinc fingers

cl11397
Location:173 → 359

NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators