Hpgds hematopoietic prostaglandin D synthase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hpgdsprovided by MGI
Official Full Name: hematopoietic prostaglandin D synthaseprovided by MGI
Primary source: MGI:MGI:1859384
See related: Ensembl:ENSMUSG00000029919 AllianceGenome:MGI:1859384
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: H-PGDS; Ptgds2
Summary: Enables prostaglandin-D synthase activity. Acts upstream of or within negative regulation of male germ cell proliferation and prostaglandin metabolic process. Predicted to be located in cytosol and nucleoplasm. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human HPGDS (hematopoietic prostaglandin D synthase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in placenta adult (RPKM 3.7), limb E14.5 (RPKM 1.5) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6; 6 C1

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (65094277..65121961, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (65117293..65144981, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Overexpressing HPGDS in adipose-derived mesenchymal stem cells reduces inflammatory state and improves wound healing in type 2 diabetic mice.
Title: Overexpressing HPGDS in adipose-derived mesenchymal stem cells reduces inflammatory state and improves wound healing in type 2 diabetic mice.
Validation of differentially expressed genes (DEGs) by quantitative RT-PCR showed a significant increase in PLA2 group 4c (Pla2g4c)/COX-2 (Ptgs2)/PGD2 synthase 2 (Hpgds) axis. PGD2 level in bronchoalveolar fluids of the OA-challenged mice was significantly increased. A 24-h incubation of BSM tissues with PGD2 caused a hyperresponsiveness to acetylcholine in naive control mice.
Title: Augmented Pla2g4c/Ptgs2/Hpgds axis in bronchial smooth muscle tissues of experimental asthma.
H-PGDS deficiency accelerates the production of SDF-1alpha and the activity of MMP-9 in the antigen-stimulated intestine. SDF-1alpha receptor blockade or MMP-9 inhibition relieves the exacerbated mast cell hyperplasia and manifestations observed in H-PGDS(-/-).
Title: PGD2 deficiency exacerbates food antigen-induced mast cell hyperplasia.
HPGDS may play a role in the regulation of inflammation and epithelial cell health within the oviduct.
Title: Hematopoetic prostaglandin D synthase: an ESR1-dependent oviductal epithelial cell synthase.
Data suggest a role for hematopoietic prostaglandin D synthase-produced prostaglandin D(2) in the initial nuclear translocation of SOX9.
Title: Hematopoietic prostaglandin D synthase (H-Pgds) is expressed in the early embryonic gonad and participates to the initial nuclear translocation of the SOX9 protein.
These data suggest that PGD(2) generated via HPGDS has detrimental effects after spinal cord injury and that blocking the activity of this enzyme can be beneficial.
Title: Expression and detrimental role of hematopoietic prostaglandin D synthase in spinal cord contusion injury.
Our results demonstrated that the neuroprotective effects of HPGDS in our model are mediated by suppression of activation and infiltration of inflammatory cells.
Title: Protective role of hematopoietic prostaglandin D synthase in transient focal cerebral ischemia in mice.
hPGD(2)S-derived cyclopentenone prostaglandins may protect against inflammatory diseases, where T lymphocytes play a pathogenic role, as in rheumatoid arthritis, atopic eczema, and chronic rejection
Title: Essential role for hematopoietic prostaglandin D2 synthase in the control of delayed type hypersensitivity.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (1)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:491413

D6Mit174 (e-PCR), detects polymorphism
- UniSTS:130718

Homology

Homologs of the Hpgds gene: The Hpgds gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, fruit fly, mosquito, C.elegans, and frog.
Orthologs from Annotation Pipeline: 325 organisms have orthologs with human gene Hpgds
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables glutathione transferase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables glutathione transferase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables isomerase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables prostaglandin-D synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables prostaglandin-D synthase activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glutathione metabolic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of male germ cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within prostaglandin biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within prostaglandin metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in prostaglandin metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: hematopoietic prostaglandin D synthase

Names: GST class-sigma; glutathione S-transferase; glutathione-dependent PGD synthase; glutathione-dependent PGD synthetase; glutathione-requiring prostaglandin D synthase; prostaglandin D2 synthase 2, hematopoietic; prostaglandin-H2 D-isomerase

NP_062328.3

EC 2.5.1.18

EC 5.3.99.2

XP_006506461.1

EC 2.5.1.18

EC 5.3.99.2

XP_036008129.1

EC 2.5.1.18

EC 5.3.99.2

XP_036008130.1

EC 2.5.1.18

EC 5.3.99.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001411252.1 → NP_001398181.1 hematopoietic prostaglandin D synthase isoform 2

Status: VALIDATED

Source sequence(s)

AC143330
NM_019455.5 → NP_062328.3 hematopoietic prostaglandin D synthase isoform 1

See identical proteins and their annotated locations for NP_062328.3

Status: VALIDATED

Source sequence(s)

AC143330

Consensus CDS

CCDS20205.1

UniProtKB/Swiss-Prot

Q8CA80, Q9JHF7

Related

ENSMUSP00000031982.5, ENSMUST00000031982.5

Conserved Domains (3) summary

PTZ00057
Location:3 → 197

PTZ00057; glutathione s-transferase; Provisional

cd10295
Location:83 → 181

GST_C_Sigma; C-terminal, alpha helical domain of Class Sigma Glutathione S-transferases

cd03039
Location:4 → 73

GST_N_Sigma_like; GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

65094277..65121961 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006506398.5 → XP_006506461.1 hematopoietic prostaglandin D synthase isoform X1

Conserved Domains (2) summary

cd10295
Location:83 → 182

GST_C_Sigma; C-terminal, alpha helical domain of Class Sigma Glutathione S-transferases

cd03039
Location:4 → 73

GST_N_Sigma_like; GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of ...
XM_036152236.1 → XP_036008129.1 hematopoietic prostaglandin D synthase isoform X1

Conserved Domains (2) summary

cd10295
Location:83 → 182

GST_C_Sigma; C-terminal, alpha helical domain of Class Sigma Glutathione S-transferases

cd03039
Location:4 → 73

GST_N_Sigma_like; GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of ...
XM_036152237.1 → XP_036008130.1 hematopoietic prostaglandin D synthase isoform X2

Conserved Domains (2) summary

cd03039
Location:4 → 73

GST_N_Sigma_like; GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of ...

cl02776
Location:83 → 123

GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family