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HPGDS hematopoietic prostaglandin D synthase [ Homo sapiens (human) ]

Gene ID: 27306, updated on 12-Oct-2019

Summary

Official Symbol
HPGDSprovided by HGNC
Official Full Name
hematopoietic prostaglandin D synthaseprovided by HGNC
Primary source
HGNC:HGNC:17890
See related
Ensembl:ENSG00000163106 MIM:602598
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GSTS; PGD2; PGDS; GSTS1; GSTS1-1
Summary
Prostaglandin-D synthase is a sigma class glutathione-S-transferase family member. The enzyme catalyzes the conversion of PGH2 to PGD2 and plays a role in the production of prostanoids in the immune system and mast cells. The presence of this enzyme can be used to identify the differentiation stage of human megakaryocytes. [provided by RefSeq, Jul 2008]
Expression
Broad expression in placenta (RPKM 12.7), lung (RPKM 6.6) and 16 other tissues See more
Orthologs

Genomic context

See HPGDS in Genome Data Viewer
Location:
4q22.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (94298535..94342876, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (95219707..95264027, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101929210 Neighboring gene high mobility group box 3 pseudogene 15 Neighboring gene SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1 Neighboring gene ribosomal protein L35a pseudogene 11 Neighboring gene PDZ and LIM domain 5

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
glutathione transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
prostaglandin-D synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cyclooxygenase pathway TAS
Traceable Author Statement
more info
 
glutathione derivative biosynthetic process TAS
Traceable Author Statement
more info
 
glutathione metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
locomotory behavior TAS
Traceable Author Statement
more info
PubMed 
negative regulation of male germ cell proliferation IEA
Inferred from Electronic Annotation
more info
 
prostaglandin metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
signal transduction NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
hematopoietic prostaglandin D synthase
Names
GST class-sigma
epididymis secretory sperm binding protein
glutathione S-transferase sigma
glutathione-dependent PGD synthase
glutathione-dependent PGD synthetase
glutathione-requiring prostaglandin D synthase
hematopoietic prostaglandin D2 synthase
prostaglandin-H2 D-isomerase
NP_055300.1
XP_005262989.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032150.1 RefSeqGene

    Range
    5041..49342
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_014485.3NP_055300.1  hematopoietic prostaglandin D synthase

    See identical proteins and their annotated locations for NP_055300.1

    Status: REVIEWED

    Source sequence(s)
    AC096746, BC020734
    Consensus CDS
    CCDS3640.1
    UniProtKB/Swiss-Prot
    O60760
    Related
    ENSP00000295256.5, ENST00000295256.10
    Conserved Domains (2) summary
    cd10295
    Location:82181
    GST_C_Sigma; C-terminal, alpha helical domain of Class Sigma Glutathione S-transferases
    cd03039
    Location:473
    GST_N_Sigma_like; GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    94298535..94342876 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005262932.3XP_005262989.1  hematopoietic prostaglandin D synthase isoform X1

    Conserved Domains (3) summary
    PTZ00057
    Location:3166
    PTZ00057; glutathione s-transferase; Provisional
    cd10295
    Location:51150
    GST_C_Sigma; C-terminal, alpha helical domain of Class Sigma Glutathione S-transferases
    cd03039
    Location:443
    GST_N_Sigma_like; GST_N family, Class Sigma_like; composed of GSTs belonging to class Sigma and similar proteins, including GSTs from class Mu, Pi and Alpha. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of ...
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