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PLEKHA5 pleckstrin homology domain containing A5 [ Homo sapiens (human) ]

Gene ID: 54477, updated on 24-Nov-2020

Summary

Official Symbol
PLEKHA5provided by HGNC
Official Full Name
pleckstrin homology domain containing A5provided by HGNC
Primary source
HGNC:HGNC:30036
See related
Ensembl:ENSG00000052126 MIM:607770
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PEPP2; PEPP-2
Expression
Ubiquitous expression in kidney (RPKM 6.7), ovary (RPKM 5.6) and 24 other tissues See more
Orthologs

Genomic context

See PLEKHA5 in Genome Data Viewer
Location:
12p12.3
Exon count:
44
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (19129680..19376400)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (19282626..19529334)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein L7 pseudogene 6 Neighboring gene MEF2B neighbor pseudogene 1 Neighboring gene RNA, 7SL, cytoplasmic 459, pseudogene Neighboring gene uncharacterized LOC112268092 Neighboring gene RNA, 7SL, cytoplasmic 67, pseudogene Neighboring gene serine and arginine rich splicing factor 11 pseudogene 1 Neighboring gene programmed cell death 5 pseudogene 1 Neighboring gene AE binding protein 2 Neighboring gene RNA, U6 small nuclear 254, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10667, FLJ26734, FLJ31492, KIAA1686

Gene Ontology Provided by GOA

Function Evidence Code Pubs
phosphatidylinositol-3,5-bisphosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol-3-phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol-4-phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol-5-phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
biological_process ND
No biological Data available
more info
 
reproductive system development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
membrane HDA PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
pleckstrin homology domain-containing family A member 5
Names
PH domain-containing family A member 5
phosphoinositol 3-phosphate-binding protein-2
pleckstrin homology domain containing, family A member 5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001143821.3NP_001137293.2  pleckstrin homology domain-containing family A member 5 isoform 2

    See identical proteins and their annotated locations for NP_001137293.2

    Status: VALIDATED

    Source sequence(s)
    AB051473, AC087314, AC091805, AC092828
    Consensus CDS
    CCDS44840.2
    UniProtKB/Swiss-Prot
    Q9HAU0
    UniProtKB/TrEMBL
    A0A024RAY7
    Related
    ENSP00000439673.1, ENST00000538714.5
    Conserved Domains (3) summary
    cd13248
    Location:164267
    PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00169
    Location:170266
    PH; PH domain
    pfam00397
    Location:5887
    WW; WW domain
  2. NM_001190860.3NP_001177789.2  pleckstrin homology domain-containing family A member 5 isoform 3

    See identical proteins and their annotated locations for NP_001177789.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the 3' coding region, lacks several 3' coding exons and differs in the 3' UTR, compared to variant 5. This results in a shorter protein (isoform 3), compared to isoform 4.
    Source sequence(s)
    AC024902, AC092828, BC044245
    Consensus CDS
    CCDS55809.1
    UniProtKB/Swiss-Prot
    Q9HAU0
    Related
    ENSP00000439396.1, ENST00000540972.5
    Conserved Domains (1) summary
    pfam00397
    Location:1241
    WW; WW domain
  3. NM_001256470.2NP_001243399.1  pleckstrin homology domain-containing family A member 5 isoform 4

    See identical proteins and their annotated locations for NP_001243399.1

    Status: VALIDATED

    Source sequence(s)
    AB642244, AC091805, AC092828, AL834259
    Consensus CDS
    CCDS58213.1
    UniProtKB/Swiss-Prot
    Q9HAU0
    Related
    ENSP00000404296.2, ENST00000429027.6
    Conserved Domains (3) summary
    cd13248
    Location:164267
    PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00169
    Location:170266
    PH; PH domain
    pfam00397
    Location:5887
    WW; WW domain
  4. NM_001256787.2NP_001243716.1  pleckstrin homology domain-containing family A member 5 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC024902, AC087314, AC091805
    Consensus CDS
    CCDS58214.1
    UniProtKB/Swiss-Prot
    Q9HAU0
    Related
    ENSP00000400411.2, ENST00000424268.5
    Conserved Domains (2) summary
    cd13248
    Location:56159
    PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00169
    Location:62158
    PH; PH domain
  5. NM_001385923.1NP_001372852.1  pleckstrin homology domain-containing family A member 5 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC024902, AC087314, AC091805, AC092828
  6. NM_001385924.1NP_001372853.1  pleckstrin homology domain-containing family A member 5 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC024902, AC087314, AC091805, AC092828
  7. NM_001385925.1NP_001372854.1  pleckstrin homology domain-containing family A member 5 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC024902, AC087314, AC091805, AC092828
  8. NM_001385926.1NP_001372855.1  pleckstrin homology domain-containing family A member 5 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC024902, AC087314, AC091805, AC092828
  9. NM_001385927.1NP_001372856.1  pleckstrin homology domain-containing family A member 5 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC024902, AC087314, AC091805, AC092828
  10. NM_001385928.1NP_001372857.1  pleckstrin homology domain-containing family A member 5 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC024902, AC087314, AC091805, AC092828
  11. NM_001385929.1NP_001372858.1  pleckstrin homology domain-containing family A member 5 isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC024902, AC087314, AC091805, AC092828
  12. NM_001385930.1NP_001372859.1  pleckstrin homology domain-containing family A member 5 isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC024902, AC087314, AC091805, AC092828
  13. NM_001385931.1NP_001372860.1  pleckstrin homology domain-containing family A member 5 isoform 14

    Status: VALIDATED

    Source sequence(s)
    AC024902, AC087314, AC091805, AC092828
  14. NM_001385932.1NP_001372861.1  pleckstrin homology domain-containing family A member 5 isoform 15

    Status: VALIDATED

    Source sequence(s)
    AC024902, AC087314, AC091805, AC092828
  15. NM_001385933.1NP_001372862.1  pleckstrin homology domain-containing family A member 5 isoform 16

    Status: VALIDATED

    Source sequence(s)
    AC024902, AC087314, AC091805
  16. NM_001385934.1NP_001372863.1  pleckstrin homology domain-containing family A member 5 isoform 17

    Status: VALIDATED

    Source sequence(s)
    AC024902, AC087314, AC091805, AC092828
  17. NM_001385935.1NP_001372864.1  pleckstrin homology domain-containing family A member 5 isoform 18

    Status: VALIDATED

    Source sequence(s)
    AC024902, AC087314, AC091805
  18. NM_001385936.1NP_001372865.1  pleckstrin homology domain-containing family A member 5 isoform 19

    Status: VALIDATED

    Source sequence(s)
    AC024902, AC087314, AC091805, AC092828
  19. NM_001385937.1NP_001372866.1  pleckstrin homology domain-containing family A member 5 isoform 20

    Status: VALIDATED

    Source sequence(s)
    AC024902, AC087314, AC091805, AC092828
  20. NM_001385938.1NP_001372867.1  pleckstrin homology domain-containing family A member 5 isoform 21

    Status: VALIDATED

    Source sequence(s)
    AC024902, AC087314, AC091805, AC092828
  21. NM_001385939.1NP_001372868.1  pleckstrin homology domain-containing family A member 5 isoform 22

    Status: VALIDATED

    Source sequence(s)
    AC024902, AC087314, AC091805
  22. NM_001385940.1NP_001372869.1  pleckstrin homology domain-containing family A member 5 isoform 23

    Status: VALIDATED

    Source sequence(s)
    AC024902, AC087314, AC091805
  23. NM_001385941.1NP_001372870.1  pleckstrin homology domain-containing family A member 5 isoform 24

    Status: VALIDATED

    Source sequence(s)
    AC024902, AC087314, AC091805
  24. NM_001385942.1NP_001372871.1  pleckstrin homology domain-containing family A member 5 isoform 25

    Status: VALIDATED

    Source sequence(s)
    AC024902, AC087314, AC091805
  25. NM_001385943.1NP_001372872.1  pleckstrin homology domain-containing family A member 5 isoform 26

    Status: VALIDATED

    Source sequence(s)
    AC024902, AC087314, AC091805, AC092828
  26. NM_001385944.1NP_001372873.1  pleckstrin homology domain-containing family A member 5 isoform 27

    Status: VALIDATED

    Source sequence(s)
    AC024902, AC087314, AC091805
  27. NM_001385945.1NP_001372874.1  pleckstrin homology domain-containing family A member 5 isoform 28

    Status: VALIDATED

    Source sequence(s)
    AC024902, AC087314, AC091805
  28. NM_001385946.1NP_001372875.1  pleckstrin homology domain-containing family A member 5 isoform 29

    Status: VALIDATED

    Source sequence(s)
    AC024902, AC087314, AC091805, AC092828
  29. NM_001385947.1NP_001372876.1  pleckstrin homology domain-containing family A member 5 isoform 30

    Status: VALIDATED

    Source sequence(s)
    AC024902, AC087314, AC091805
  30. NM_001385948.1NP_001372877.1  pleckstrin homology domain-containing family A member 5 isoform 31

    Status: VALIDATED

    Source sequence(s)
    AC024902, AC087314, AC091805, AC092828
  31. NM_001385949.1NP_001372878.1  pleckstrin homology domain-containing family A member 5 isoform 32

    Status: VALIDATED

    Source sequence(s)
    AC024902, AC087314, AC091805, AC092828
  32. NM_001385950.1NP_001372879.1  pleckstrin homology domain-containing family A member 5 isoform 33

    Status: VALIDATED

    Source sequence(s)
    AC024902, AC087314, AC091805
    Related
    ENSP00000440371.1, ENST00000536974.5
  33. NM_001385951.1NP_001372880.1  pleckstrin homology domain-containing family A member 5 isoform 34

    Status: VALIDATED

    Source sequence(s)
    AC024902, AC087314, AC091805
  34. NM_001385952.1NP_001372881.1  pleckstrin homology domain-containing family A member 5 isoform 35

    Status: VALIDATED

    Source sequence(s)
    AC024902, AC087314, AC091805
  35. NM_001385953.1NP_001372882.1  pleckstrin homology domain-containing family A member 5 isoform 36

    Status: VALIDATED

    Source sequence(s)
    AC024902, AC087314, AC091805
  36. NM_001385954.1NP_001372883.1  pleckstrin homology domain-containing family A member 5 isoform 37

    Status: VALIDATED

    Source sequence(s)
    AC024902, AC087314, AC091805
  37. NM_001385955.1NP_001372884.1  pleckstrin homology domain-containing family A member 5 isoform 38

    Status: VALIDATED

    Source sequence(s)
    AC024902, AC087314, AC091805
    Related
    ENSP00000440611.1, ENST00000539256.5
  38. NM_001385956.1NP_001372885.1  pleckstrin homology domain-containing family A member 5 isoform 38

    Status: VALIDATED

    Source sequence(s)
    AC024902, AC087314, AC091805
  39. NM_001385957.1NP_001372886.1  pleckstrin homology domain-containing family A member 5 isoform 38

    Status: VALIDATED

    Source sequence(s)
    AC024902, AC087314, AC091805
  40. NM_001385958.1NP_001372887.1  pleckstrin homology domain-containing family A member 5 isoform 39

    Status: VALIDATED

    Source sequence(s)
    AC024902, AC087314, AC091805
  41. NM_001385959.1NP_001372888.1  pleckstrin homology domain-containing family A member 5 isoform 40

    Status: VALIDATED

    Source sequence(s)
    AC024902, AC087314, AC091805
  42. NM_001385960.1NP_001372889.1  pleckstrin homology domain-containing family A member 5 isoform 41

    Status: VALIDATED

    Source sequence(s)
    AC024902, AC087314, AC091805
  43. NM_001385961.1NP_001372890.1  pleckstrin homology domain-containing family A member 5 isoform 42

    Status: VALIDATED

    Source sequence(s)
    AC024902, AC087314, AC091805
  44. NM_001385962.1NP_001372891.1  pleckstrin homology domain-containing family A member 5 isoform 43

    Status: VALIDATED

    Source sequence(s)
    AC024902, AC087314, AC091805
  45. NM_001385963.1NP_001372892.1  pleckstrin homology domain-containing family A member 5 isoform 44

    Status: VALIDATED

    Source sequence(s)
    AC024902, AC087314, AC091805
  46. NM_001385964.1NP_001372893.1  pleckstrin homology domain-containing family A member 5 isoform 45

    Status: VALIDATED

    Source sequence(s)
    AC024902, AC087314, AC091805
  47. NM_001385965.1NP_001372894.1  pleckstrin homology domain-containing family A member 5 isoform 46

    Status: VALIDATED

    Source sequence(s)
    AC024902, AC087314, AC091805
  48. NM_001385966.1NP_001372895.1  pleckstrin homology domain-containing family A member 5 isoform 47

    Status: VALIDATED

    Source sequence(s)
    AC024902, AC087314, AC091805
  49. NM_001385967.1NP_001372896.1  pleckstrin homology domain-containing family A member 5 isoform 48

    Status: VALIDATED

    Source sequence(s)
    AC024902, AC087314, AC091805
  50. NM_001385968.1NP_001372897.1  pleckstrin homology domain-containing family A member 5 isoform 16

    Status: VALIDATED

    Source sequence(s)
    AC024902, AC087314, AC091805, AC092828
  51. NM_001385969.1NP_001372898.1  pleckstrin homology domain-containing family A member 5 isoform 39

    Status: VALIDATED

    Source sequence(s)
    AC024902, AC087314, AC091805
  52. NM_001385970.1NP_001372899.1  pleckstrin homology domain-containing family A member 5 isoform 39

    Status: VALIDATED

    Source sequence(s)
    AC024902, AC087314, AC091805
  53. NM_001385971.1NP_001372900.1  pleckstrin homology domain-containing family A member 5 isoform 39

    Status: VALIDATED

    Source sequence(s)
    AC024902, AC087314, AC091805
  54. NM_001385972.1NP_001372901.1  pleckstrin homology domain-containing family A member 5 isoform 39

    Status: VALIDATED

    Source sequence(s)
    AC024902, AC087314, AC091805
  55. NM_001385973.1NP_001372902.1  pleckstrin homology domain-containing family A member 5 isoform 39

    Status: VALIDATED

    Source sequence(s)
    AC024902, AC087314, AC091805
  56. NM_019012.6NP_061885.2  pleckstrin homology domain-containing family A member 5 isoform 1

    See identical proteins and their annotated locations for NP_061885.2

    Status: VALIDATED

    Source sequence(s)
    AC091805, AC092828, AF302150
    Consensus CDS
    CCDS8682.1
    UniProtKB/Swiss-Prot
    Q9HAU0
    Related
    ENSP00000299275.6, ENST00000299275.10
    Conserved Domains (3) summary
    cd13248
    Location:164267
    PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00169
    Location:170266
    PH; PH domain
    pfam00397
    Location:5887
    WW; WW domain

RNA

  1. NR_169816.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC024902, AC087314, AC091805, AC092828
  2. NR_169817.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC024902, AC087314, AC091805, AC092828
  3. NR_169818.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC024902, AC087314, AC091805, AC092828
  4. NR_169819.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC024902, AC087314, AC091805, AC092828
  5. NR_169820.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC024902, AC087314, AC091805, AC092828
  6. NR_169821.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC024902, AC087314, AC091805, AC092828

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    19129680..19376400
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017019502.1XP_016874991.1  pleckstrin homology domain-containing family A member 5 isoform X16

  2. XM_017019503.1XP_016874992.1  pleckstrin homology domain-containing family A member 5 isoform X17

    UniProtKB/Swiss-Prot
    Q9HAU0
    Conserved Domains (1) summary
    pfam00397
    Location:1241
    WW; WW domain
  3. XM_017019495.1XP_016874984.1  pleckstrin homology domain-containing family A member 5 isoform X2

  4. XM_017019496.1XP_016874985.1  pleckstrin homology domain-containing family A member 5 isoform X6

  5. XM_011520715.1XP_011519017.1  pleckstrin homology domain-containing family A member 5 isoform X4

    Conserved Domains (3) summary
    cd13248
    Location:164267
    PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00169
    Location:170266
    PH; PH domain
    pfam00397
    Location:5887
    WW; WW domain
  6. XM_006719091.1XP_006719154.1  pleckstrin homology domain-containing family A member 5 isoform X7

    Conserved Domains (3) summary
    cd13248
    Location:164267
    PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00169
    Location:170266
    PH; PH domain
    pfam00397
    Location:5887
    WW; WW domain
  7. XM_006719093.1XP_006719156.1  pleckstrin homology domain-containing family A member 5 isoform X11

    Conserved Domains (3) summary
    cd13248
    Location:164267
    PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00169
    Location:170266
    PH; PH domain
    pfam00397
    Location:5887
    WW; WW domain
  8. XM_017019499.1XP_016874988.1  pleckstrin homology domain-containing family A member 5 isoform X13

  9. XM_017019500.1XP_016874989.1  pleckstrin homology domain-containing family A member 5 isoform X14

  10. XM_017019501.1XP_016874990.1  pleckstrin homology domain-containing family A member 5 isoform X15

  11. XM_017019497.1XP_016874986.1  pleckstrin homology domain-containing family A member 5 isoform X10

RNA

  1. XR_001748773.1 RNA Sequence

  2. XR_001748772.1 RNA Sequence

  3. XR_002957340.1 RNA Sequence

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