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Plekha5 pleckstrin homology domain containing, family A member 5 [ Mus musculus (house mouse) ]

Gene ID: 109135, updated on 28-Feb-2023

Summary

Official Symbol
Plekha5provided by MGI
Official Full Name
pleckstrin homology domain containing, family A member 5provided by MGI
Primary source
MGI:MGI:1923802
See related
Ensembl:ENSMUSG00000030231 AllianceGenome:MGI:1923802
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pepp2; AMH-Cre; Ayu21-9; 2810431N21Rik; Gt(pU21)9Imeg; Tg(AMH-cre)1Flor
Summary
Enables phosphatidylinositol phosphate binding activity. Acts upstream of or within reproductive system development. Located in cytosol and postsynaptic density. Is active in glutamatergic synapse. Is expressed in several structures, including brain; ganglia; gonad; metanephros; and trigeminal nerve. Orthologous to human PLEKHA5 (pleckstrin homology domain containing A5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in frontal lobe adult (RPKM 10.9), CNS E14 (RPKM 9.4) and 28 other tissues See more
Orthologs
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Genomic context

See Plekha5 in Genome Data Viewer
Location:
6; 6 G2
Exon count:
34
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (140369358..140542836)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (140423639..140597110)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38917 Neighboring gene predicted gene 5051 Neighboring gene AE binding protein 2 Neighboring gene predicted gene, 30215 Neighboring gene ribosomal protein L38, pseudogene 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Transgenic (1)  1 citation
  • Gene trapped (1) 
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC38455

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within reproductive system development IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynaptic density EXP
Inferred from Experiment
more info
PubMed 
is_active_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
pleckstrin homology domain-containing family A member 5
Names
Gt(Ayu21)9Imeg
phosphoinositol 3-phosphate-binding protein-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144920.3NP_659169.3  pleckstrin homology domain-containing family A member 5

    Status: VALIDATED

    Source sequence(s)
    AK129423, CJ170110
    Consensus CDS
    CCDS39688.1
    UniProtKB/TrEMBL
    E9Q6H8, Q6ZPK1
    Related
    ENSMUSP00000084904.4, ENSMUST00000087622.6
    Conserved Domains (3) summary
    COG1196
    Location:623864
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd13248
    Location:165268
    PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00397
    Location:5988
    WW; WW domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    140369358..140542836
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006506863.3XP_006506926.1  pleckstrin homology domain-containing family A member 5 isoform X1

    Conserved Domains (3) summary
    COG1196
    Location:623864
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd13248
    Location:165268
    PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00397
    Location:5988
    WW; WW domain
  2. XM_006506864.3XP_006506927.1  pleckstrin homology domain-containing family A member 5 isoform X8

    Conserved Domains (3) summary
    cd13248
    Location:165268
    PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    TIGR03185
    Location:632830
    DNA_S_dndD; DNA sulfur modification protein DndD
    pfam00397
    Location:5988
    WW; WW domain
  3. XM_006506869.3XP_006506932.1  pleckstrin homology domain-containing family A member 5 isoform X15

    Conserved Domains (3) summary
    cd13248
    Location:165268
    PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    TIGR03185
    Location:632830
    DNA_S_dndD; DNA sulfur modification protein DndD
    pfam00397
    Location:5988
    WW; WW domain
  4. XM_017321307.2XP_017176796.1  pleckstrin homology domain-containing family A member 5 isoform X2

    UniProtKB/TrEMBL
    E9Q6H8
    Conserved Domains (3) summary
    COG1196
    Location:623864
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd13248
    Location:165268
    PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00397
    Location:5988
    WW; WW domain
  5. XM_017321309.2XP_017176798.1  pleckstrin homology domain-containing family A member 5 isoform X16

    Conserved Domains (3) summary
    cd13248
    Location:165268
    PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    TIGR03185
    Location:632830
    DNA_S_dndD; DNA sulfur modification protein DndD
    pfam00397
    Location:5988
    WW; WW domain
  6. XM_006506866.3XP_006506929.1  pleckstrin homology domain-containing family A member 5 isoform X10

    Conserved Domains (2) summary
    cd13248
    Location:165268
    PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00397
    Location:5988
    WW; WW domain
  7. XM_006506861.3XP_006506924.1  pleckstrin homology domain-containing family A member 5 isoform X5

    Conserved Domains (3) summary
    COG1196
    Location:623852
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd13248
    Location:165268
    PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00397
    Location:5988
    WW; WW domain
  8. XM_006506862.3XP_006506925.1  pleckstrin homology domain-containing family A member 5 isoform X6

    Conserved Domains (3) summary
    COG1196
    Location:623852
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd13248
    Location:165268
    PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00397
    Location:5988
    WW; WW domain
  9. XM_036165737.1XP_036021630.1  pleckstrin homology domain-containing family A member 5 isoform X18

    Conserved Domains (3) summary
    COG1196
    Location:623852
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd13248
    Location:165268
    PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00397
    Location:5988
    WW; WW domain
  10. XM_006506867.3XP_006506930.1  pleckstrin homology domain-containing family A member 5 isoform X11

    Conserved Domains (3) summary
    COG1196
    Location:623842
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd13248
    Location:165268
    PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00397
    Location:5988
    WW; WW domain
  11. XM_030255075.2XP_030110935.1  pleckstrin homology domain-containing family A member 5 isoform X12

    Conserved Domains (3) summary
    COG1196
    Location:623842
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd13248
    Location:165268
    PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00397
    Location:5988
    WW; WW domain
  12. XM_006506868.3XP_006506931.1  pleckstrin homology domain-containing family A member 5 isoform X13

    Conserved Domains (3) summary
    cd13248
    Location:165268
    PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    TIGR02169
    Location:639835
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    pfam00397
    Location:5988
    WW; WW domain
  13. XM_006506873.3XP_006506936.1  pleckstrin homology domain-containing family A member 5 isoform X21

    Conserved Domains (3) summary
    COG1196
    Location:638767
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd13248
    Location:165268
    PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00397
    Location:5988
    WW; WW domain
  14. XM_006506880.3XP_006506943.1  pleckstrin homology domain-containing family A member 5 isoform X30

    Conserved Domains (3) summary
    COG1196
    Location:638767
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd13248
    Location:165268
    PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00397
    Location:5988
    WW; WW domain
  15. XM_006506874.3XP_006506937.1  pleckstrin homology domain-containing family A member 5 isoform X22

    Conserved Domains (3) summary
    COG1196
    Location:641809
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd13248
    Location:165268
    PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00397
    Location:5988
    WW; WW domain
  16. XM_006506878.3XP_006506941.1  pleckstrin homology domain-containing family A member 5 isoform X28

    Conserved Domains (3) summary
    COG1196
    Location:641809
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd13248
    Location:165268
    PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00397
    Location:5988
    WW; WW domain
  17. XM_030255080.2XP_030110940.1  pleckstrin homology domain-containing family A member 5 isoform X31

    Conserved Domains (3) summary
    COG1196
    Location:641806
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd13248
    Location:165268
    PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00397
    Location:5988
    WW; WW domain
  18. XM_006506883.3XP_006506946.1  pleckstrin homology domain-containing family A member 5 isoform X34

    Conserved Domains (3) summary
    COG1196
    Location:641806
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd13248
    Location:165268
    PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00397
    Location:5988
    WW; WW domain
  19. XM_006506860.3XP_006506923.1  pleckstrin homology domain-containing family A member 5 isoform X3

    Conserved Domains (3) summary
    COG1196
    Location:617858
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd13248
    Location:165268
    PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00397
    Location:5988
    WW; WW domain
  20. XM_036165734.1XP_036021627.1  pleckstrin homology domain-containing family A member 5 isoform X4

    Conserved Domains (3) summary
    COG1196
    Location:617858
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd13248
    Location:165268
    PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00397
    Location:5988
    WW; WW domain
  21. XM_036165736.1XP_036021629.1  pleckstrin homology domain-containing family A member 5 isoform X17

    Conserved Domains (3) summary
    COG1196
    Location:617858
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd13248
    Location:165268
    PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00397
    Location:5988
    WW; WW domain
  22. XM_006506898.3XP_006506961.1  pleckstrin homology domain-containing family A member 5 isoform X7

    Conserved Domains (3) summary
    cd13248
    Location:165268
    PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    TIGR03185
    Location:626812
    DNA_S_dndD; DNA sulfur modification protein DndD
    pfam00397
    Location:5988
    WW; WW domain
  23. XM_036165738.1XP_036021631.1  pleckstrin homology domain-containing family A member 5 isoform X19

    Conserved Domains (3) summary
    COG1196
    Location:617846
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd13248
    Location:165268
    PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00397
    Location:5988
    WW; WW domain
  24. XM_006506875.3XP_006506938.1  pleckstrin homology domain-containing family A member 5 isoform X25

    Related
    ENSMUSP00000145478.2, ENSMUST00000203517.3
    Conserved Domains (3) summary
    COG1196
    Location:617836
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd13248
    Location:165268
    PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00397
    Location:5988
    WW; WW domain
  25. XM_036165739.1XP_036021632.1  pleckstrin homology domain-containing family A member 5 isoform X23

    Conserved Domains (3) summary
    COG1196
    Location:632761
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd13248
    Location:165268
    PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00397
    Location:5988
    WW; WW domain
  26. XM_006506881.3XP_006506944.1  pleckstrin homology domain-containing family A member 5 isoform X32

    Conserved Domains (3) summary
    COG1196
    Location:632761
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd13248
    Location:165268
    PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00397
    Location:5988
    WW; WW domain
  27. XM_030255078.2XP_030110938.1  pleckstrin homology domain-containing family A member 5 isoform X24

    Conserved Domains (3) summary
    COG1196
    Location:635803
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd13248
    Location:165268
    PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00397
    Location:5988
    WW; WW domain
  28. XM_036165741.1XP_036021634.1  pleckstrin homology domain-containing family A member 5 isoform X29

    Conserved Domains (3) summary
    COG1196
    Location:635803
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd13248
    Location:165268
    PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00397
    Location:5988
    WW; WW domain
  29. XM_006506882.4XP_006506945.1  pleckstrin homology domain-containing family A member 5 isoform X33

    Conserved Domains (3) summary
    COG1196
    Location:635800
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd13248
    Location:165268
    PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00397
    Location:5988
    WW; WW domain
  30. XM_017321308.3XP_017176797.1  pleckstrin homology domain-containing family A member 5 isoform X9

    Conserved Domains (3) summary
    cd13248
    Location:165268
    PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    TIGR03185
    Location:632830
    DNA_S_dndD; DNA sulfur modification protein DndD
    pfam00397
    Location:5988
    WW; WW domain
  31. XM_030255077.2XP_030110937.1  pleckstrin homology domain-containing family A member 5 isoform X20

    Conserved Domains (3) summary
    cd13248
    Location:165268
    PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    TIGR03185
    Location:632830
    DNA_S_dndD; DNA sulfur modification protein DndD
    pfam00397
    Location:5988
    WW; WW domain
  32. XM_036165735.1XP_036021628.1  pleckstrin homology domain-containing family A member 5 isoform X14

    Conserved Domains (3) summary
    COG1196
    Location:623842
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd13248
    Location:165268
    PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00397
    Location:5988
    WW; WW domain
  33. XM_030255082.2XP_030110942.1  pleckstrin homology domain-containing family A member 5 isoform X36

    Conserved Domains (2) summary
    TIGR03185
    Location:402600
    DNA_S_dndD; DNA sulfur modification protein DndD
    cl17171
    Location:1544
    PH-like; Pleckstrin homology-like domain
  34. XM_030255083.2XP_030110943.1  pleckstrin homology domain-containing family A member 5 isoform X37

    Conserved Domains (2) summary
    COG1196
    Location:408537
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl17171
    Location:1544
    PH-like; Pleckstrin homology-like domain
  35. XM_036165742.1XP_036021635.1  pleckstrin homology domain-containing family A member 5 isoform X38

    Conserved Domains (2) summary
    COG1196
    Location:411576
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cl17171
    Location:1544
    PH-like; Pleckstrin homology-like domain
  36. XM_006506876.5XP_006506939.1  pleckstrin homology domain-containing family A member 5 isoform X26

    See identical proteins and their annotated locations for XP_006506939.1

    Conserved Domains (2) summary
    cd13248
    Location:56159
    PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
    TIGR03185
    Location:523721
    DNA_S_dndD; DNA sulfur modification protein DndD
  37. XM_036165740.1XP_036021633.1  pleckstrin homology domain-containing family A member 5 isoform X27

    Conserved Domains (2) summary
    COG1196
    Location:514755
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd13248
    Location:56159
    PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
  38. XM_006506885.3XP_006506948.1  pleckstrin homology domain-containing family A member 5 isoform X35

    Conserved Domains (2) summary
    TIGR03185
    Location:408606
    DNA_S_dndD; DNA sulfur modification protein DndD
    cl17171
    Location:1544
    PH-like; Pleckstrin homology-like domain

RNA

  1. XR_003956147.2 RNA Sequence

  2. XR_004942891.1 RNA Sequence

  3. XR_003956148.2 RNA Sequence

  4. XR_004942893.1 RNA Sequence

  5. XR_001785082.2 RNA Sequence

  6. XR_004942892.1 RNA Sequence

  7. XR_003956149.2 RNA Sequence

  8. XR_003956150.2 RNA Sequence

  9. XR_004942894.1 RNA Sequence

  10. XR_004942895.1 RNA Sequence

  11. XR_004942896.1 RNA Sequence

  12. XR_004942897.1 RNA Sequence