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MAPK10 mitogen-activated protein kinase 10 [ Bos taurus (cattle) ]

Gene ID: 537631, updated on 17-Aug-2022

Summary

Official Symbol
MAPK10provided by VGNC
Official Full Name
mitogen-activated protein kinase 10provided by VGNC
Primary source
VGNC:VGNC:31213
See related
BGD:BT11390; Ensembl:ENSBTAG00000020048
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Summary
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals, and thus are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons in the nervous system and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]
Orthologs
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Genomic context

See MAPK10 in Genome Data Viewer
Location:
chromosome: 6
Exon count:
19
Annotation release Status Assembly Chr Location
106 current ARS-UCD1.2 (GCF_002263795.1) 6 NC_037333.1 (100904659..101530092, complement)
105 previous assembly Bos_taurus_UMD_3.1.1 (GCF_000003055.6) 6 AC_000163.1 (102683802..103320828, complement)

Chromosome 6 - NC_037333.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112447118 Neighboring gene WD repeat and FYVE domain containing 3 Neighboring gene Rho GTPase activating protein 24 Neighboring gene uncharacterized LOC112447119 Neighboring gene transfer RNA cysteine (anticodon GCA) Neighboring gene transfer RNA cysteine (anticodon GCA) Neighboring gene SUMO-conjugating enzyme UBC9 pseudogene Neighboring gene transfer RNA glycine (anticodon UCC) Neighboring gene solute carrier family 10 member 6-like Neighboring gene protein tyrosine phosphatase non-receptor type 13

Genomic regions, transcripts, and products

Pathways from PubChem

General gene information

Markers

Homology

General protein information

Preferred Names
mitogen-activated protein kinase 10
NP_001077197.1
NP_001305129.1
NP_001305130.1
XP_005208248.1
XP_005208252.1
XP_005208254.1
XP_010804592.1
XP_010804594.1
XP_024849112.1
XP_024849113.1
XP_024849114.1
XP_024849115.1
XP_024849116.1
XP_024849117.1
XP_024849118.1
XP_024849119.1
XP_024849120.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083728.3NP_001077197.1  mitogen-activated protein kinase 10 isoform 2

    See identical proteins and their annotated locations for NP_001077197.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate acceptor splice site in the 5' region, which results in translation initiation from an in-frame, downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    BC123518, DV829805, EV784689
    UniProtKB/TrEMBL
    A0A8C0AFI4, A4FV00, F1N456
    Related
    ENSBTAP00000026712.5, ENSBTAT00000026712.6
    Conserved Domains (1) summary
    cd07850
    Location:25360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
  2. NM_001318200.1NP_001305129.1  mitogen-activated protein kinase 10 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1, also known as JNK3 alpha2) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UGA termination codon. This RefSeq represents the shorter isoform (1).
    Source sequence(s)
    BC123518, DV829805, EH134072, EV784689
    UniProtKB/TrEMBL
    A4FV00
    Conserved Domains (1) summary
    cd07850
    Location:63398
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
  3. NM_001318201.1NP_001305130.1  mitogen-activated protein kinase 10 isoform 1x

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1, also known as JNK3 alpha2) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UGA termination codon. This RefSeq represents the longer, C-terminally extended isoform (1x). As the UGA stop codon has been reported to specify several alternative amino acids (tryptophan, cysteine, arginine and serine), the location of the upstream UGA stop codon in the longer isoform is denoted by an 'X'.
    Source sequence(s)
    BC123518, DV829805, EH134072, EV784689
    UniProtKB/TrEMBL
    A4FV00
    Conserved Domains (2) summary
    smart00220
    Location:64359
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07850
    Location:63398
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

RefSeqs of Annotated Genomes: Bos taurus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD1.2 Primary Assembly

Genomic

  1. NC_037333.1 Reference ARS-UCD1.2 Primary Assembly

    Range
    100904659..101530092 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_010806290.3XP_010804592.1  mitogen-activated protein kinase 10 isoform X2

    See identical proteins and their annotated locations for XP_010804592.1

    Conserved Domains (1) summary
    cd07850
    Location:63398
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
  2. XM_010806292.3XP_010804594.1  mitogen-activated protein kinase 10 isoform X4

    See identical proteins and their annotated locations for XP_010804594.1

    Conserved Domains (1) summary
    cd07850
    Location:63398
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
  3. XM_024993352.1XP_024849120.1  mitogen-activated protein kinase 10 isoform X6

    UniProtKB/TrEMBL
    A0A4W2D554, A0A8B9XWA5
    Conserved Domains (1) summary
    cd07850
    Location:25360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
  4. XM_024993351.1XP_024849119.1  mitogen-activated protein kinase 10 isoform X5

    UniProtKB/TrEMBL
    A0A4W2I2C6, A0A8B9Y3U3
    Conserved Domains (1) summary
    cd07850
    Location:25360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
  5. XM_024993348.1XP_024849116.1  mitogen-activated protein kinase 10 isoform X3

    UniProtKB/TrEMBL
    A0A8C0AFI4, F1N456
    Conserved Domains (1) summary
    cd07850
    Location:25360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
  6. XM_005208191.4XP_005208248.1  mitogen-activated protein kinase 10 isoform X1

    See identical proteins and their annotated locations for XP_005208248.1

    Conserved Domains (1) summary
    cd07850
    Location:63398
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
  7. XM_005208195.4XP_005208252.1  mitogen-activated protein kinase 10 isoform X3

    See identical proteins and their annotated locations for XP_005208252.1

    UniProtKB/TrEMBL
    A0A8C0AFI4, A4FV00, F1N456
    Conserved Domains (1) summary
    cd07850
    Location:25360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
  8. XM_024993346.1XP_024849114.1  mitogen-activated protein kinase 10 isoform X3

    UniProtKB/TrEMBL
    A0A8C0AFI4, F1N456
    Conserved Domains (1) summary
    cd07850
    Location:25360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
  9. XM_024993344.1XP_024849112.1  mitogen-activated protein kinase 10 isoform X1

    Conserved Domains (1) summary
    cd07850
    Location:63398
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
  10. XM_024993347.1XP_024849115.1  mitogen-activated protein kinase 10 isoform X3

    UniProtKB/TrEMBL
    A0A8C0AFI4, F1N456
    Conserved Domains (1) summary
    cd07850
    Location:25360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
  11. XM_024993345.1XP_024849113.1  mitogen-activated protein kinase 10 isoform X1

    Conserved Domains (1) summary
    cd07850
    Location:63398
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
  12. XM_005208197.4XP_005208254.1  mitogen-activated protein kinase 10 isoform X3

    See identical proteins and their annotated locations for XP_005208254.1

    UniProtKB/TrEMBL
    A0A8C0AFI4, A4FV00, F1N456
    Related
    ENSBTAP00000059818.1, ENSBTAT00000084303.1
    Conserved Domains (1) summary
    cd07850
    Location:25360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
  13. XM_024993349.1XP_024849117.1  mitogen-activated protein kinase 10 isoform X5

    UniProtKB/TrEMBL
    A0A4W2I2C6, A0A8B9Y3U3
    Conserved Domains (1) summary
    cd07850
    Location:25360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
  14. XM_024993350.1XP_024849118.1  mitogen-activated protein kinase 10 isoform X5

    UniProtKB/TrEMBL
    A0A4W2I2C6, A0A8B9Y3U3
    Conserved Domains (1) summary
    cd07850
    Location:25360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase