U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

MAPK10 mitogen-activated protein kinase 10 [ Bos taurus (domestic cattle) ]

Gene ID: 537631, updated on 10-Oct-2024

Summary

Go to the top of the page Help
Official Symbol
MAPK10provided by VGNC
Official Full Name
mitogen-activated protein kinase 10provided by VGNC
Primary source
VGNC:VGNC:31213
See related
BGD:BT11390; Ensembl:ENSBTAG00000020048
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Summary
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals, and thus are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons in the nervous system and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See MAPK10 in Genome Data Viewer
Location:
chromosome: 6
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 6 NC_037333.1 (100907861..101530086, complement)

Chromosome 6 - NC_037333.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112447118 Neighboring gene WD repeat and FYVE domain containing 3 Neighboring gene Rho GTPase activating protein 24 Neighboring gene ragulator complex protein LAMTOR5-like Neighboring gene SUMO-conjugating enzyme UBC9-like Neighboring gene transfer RNA glycine (anticodon UCC) Neighboring gene disks large-associated protein 4-like Neighboring gene protein tyrosine phosphatase non-receptor type 13 Neighboring gene solute carrier family 10 member 6

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_037333.1 Chromosome 6 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Identification of arrestin-3-specific residues necessary for JNK3 kinase activation. Seo J, et al. J Biol Chem, 2011 Aug 12. PMID 21715332, Free PMC Article
  2. SDF-1alpha stimulates JNK3 activity via eNOS-dependent nitrosylation of MKP7 to enhance endothelial migration. Pi X, et al. Proc Natl Acad Sci U S A, 2009 Apr 7. PMID 19307591, Free PMC Article
  3. Evidence of efficient stop codon readthrough in four mammalian genes. Loughran G, et al. Nucleic Acids Res, 2014 Aug. PMID 25013167, Free PMC Article
  4. Misreading of termination codons in eukaryotes by natural nonsense suppressor tRNAs. Beier H, et al. Nucleic Acids Res, 2001 Dec 1. PMID 11726686, Free PMC Article
  5. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. multiple residues on the non-receptor-binding side of arrestin-3 are crucial for JNK3 activation
    Title: Identification of arrestin-3-specific residues necessary for JNK3 kinase activation.
  2. identification of an intricate SDF-1alpha-induced signaling cascade that involves eNOS, JNK3, and MKP7and enhances endothelial migration
    Title: SDF-1alpha stimulates JNK3 activity via eNOS-dependent nitrosylation of MKP7 to enhance endothelial migration.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables JUN kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in JNK cascade IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
mitogen-activated protein kinase 10
NP_001077197.1
NP_001305129.1
NP_001305130.1
XP_005208248.1
XP_005208252.1
XP_005208254.1
XP_010804592.1
XP_010804594.1
XP_024849113.1
XP_024849114.1
XP_059743570.1
XP_059743571.1
XP_059743572.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083728.3 → NP_001077197.1  mitogen-activated protein kinase 10 isoform 2

    See identical proteins and their annotated locations for NP_001077197.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate acceptor splice site in the 5' region, which results in translation initiation from an in-frame, downstream start codon compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    BC123518, DV829805, EV784689
    UniProtKB/TrEMBL
    A0A3Q1LXD7, A4FV00, F1N456
    Related
    ENSBTAP00000026712.5, ENSBTAT00000026712.6
    Conserved Domains (1) summary
    cd07850
    Location:25 → 360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  2. NM_001318200.1 → NP_001305129.1  mitogen-activated protein kinase 10 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1, also known as JNK3 alpha2) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UGA termination codon. This RefSeq represents the shorter isoform (1).
    Source sequence(s)
    BC123518, DV829805, EH134072, EV784689
    UniProtKB/TrEMBL
    A0A3Q1LXD7
    Conserved Domains (1) summary
    cd07850
    Location:63 → 398
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  3. NM_001318201.1 → NP_001305130.1  mitogen-activated protein kinase 10 isoform 1x

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes two isoforms, which result from the use of alternative in-frame translation termination codons. The shorter isoform (1, also known as JNK3 alpha2) results from translation termination at the upstream UGA stop codon, while the longer isoform (1x) results from UGA stop codon readthrough to the downstream UGA termination codon. This RefSeq represents the longer, C-terminally extended isoform (1x). As the UGA stop codon has been reported to specify several alternative amino acids (tryptophan, cysteine, arginine and serine), the location of the upstream UGA stop codon in the longer isoform is denoted by an 'X'.
    Source sequence(s)
    BC123518, DV829805, EH134072, EV784689
    UniProtKB/TrEMBL
    A0A3Q1LXD7
    Conserved Domains (2) summary
    smart00220
    Location:64 → 359
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07850
    Location:63 → 398
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037333.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    100907861..101530086 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_059887589.1 → XP_059743572.1  mitogen-activated protein kinase 10 isoform X2

  2. XM_005208191.5 → XP_005208248.1  mitogen-activated protein kinase 10 isoform X2

    See identical proteins and their annotated locations for XP_005208248.1

    UniProtKB/TrEMBL
    A0A3Q1LXD7
    Conserved Domains (1) summary
    cd07850
    Location:63 → 398
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  3. XM_059887587.1 → XP_059743570.1  mitogen-activated protein kinase 10 isoform X2

  4. XM_024993345.2 → XP_024849113.1  mitogen-activated protein kinase 10 isoform X2

    UniProtKB/TrEMBL
    A0A3Q1LXD7
    Related
    ENSBTAP00000059818.2, ENSBTAT00000084303.2
    Conserved Domains (1) summary
    cd07850
    Location:63 → 398
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  5. XM_010806290.4 → XP_010804592.1  mitogen-activated protein kinase 10 isoform X1

    See identical proteins and their annotated locations for XP_010804592.1

    UniProtKB/TrEMBL
    A0A3Q1LXD7
    Related
    ENSBTAP00000101844.1, ENSBTAT00000131183.1
    Conserved Domains (1) summary
    cd07850
    Location:63 → 398
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  6. XM_010806292.4 → XP_010804594.1  mitogen-activated protein kinase 10 isoform X4

    See identical proteins and their annotated locations for XP_010804594.1

    UniProtKB/TrEMBL
    Q05B47
    Conserved Domains (1) summary
    cd07850
    Location:63 → 398
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  7. XM_024993346.2 → XP_024849114.1  mitogen-activated protein kinase 10 isoform X3

    UniProtKB/TrEMBL
    A0A3Q1LXD7, A4FV00, F1N456
    Conserved Domains (1) summary
    cd07850
    Location:25 → 360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  8. XM_005208195.5 → XP_005208252.1  mitogen-activated protein kinase 10 isoform X3

    See identical proteins and their annotated locations for XP_005208252.1

    UniProtKB/TrEMBL
    A0A3Q1LXD7, A4FV00, F1N456
    Conserved Domains (1) summary
    cd07850
    Location:25 → 360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase

  9. XM_059887588.1 → XP_059743571.1  mitogen-activated protein kinase 10 isoform X2

  10. XM_005208197.5 → XP_005208254.1  mitogen-activated protein kinase 10 isoform X3

    See identical proteins and their annotated locations for XP_005208254.1

    UniProtKB/TrEMBL
    A0A3Q1LXD7, A4FV00, F1N456
    Conserved Domains (1) summary
    cd07850
    Location:25 → 360
    STKc_JNK; Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials