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PLS3 plastin 3 [ Homo sapiens (human) ]

Gene ID: 5358, updated on 9-Dec-2018

Summary

Official Symbol
PLS3provided by HGNC
Official Full Name
plastin 3provided by HGNC
Primary source
HGNC:HGNC:9091
See related
Ensembl:ENSG00000102024 MIM:300131
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BMND18; T-plastin
Summary
Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). The C-terminal 570 amino acids of the T-plastin and L-plastin proteins are 83% identical. It contains a potential calcium-binding site near the N terminus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2010]
Expression
Ubiquitous expression in thyroid (RPKM 88.8), lung (RPKM 70.6) and 23 other tissues See more
Orthologs

Genomic context

See PLS3 in Genome Data Viewer
Location:
Xq23
Exon count:
20
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) X NC_000023.11 (115560850..115650861)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (114795177..114885181)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene tubulin alpha 1a pseudogene Neighboring gene UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like protein 1 Neighboring gene PLS3 antisense RNA 1 Neighboring gene PHD finger-like domain-containing protein 5A pseudogene Neighboring gene PHD finger protein 5F pseudogene Neighboring gene argininosuccinate synthetase 1 pseudogene 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify plastin 3 (PLS3), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
env HIV-1 gp120 upregulates the expression of T-plastin and downregulates the expression of L-plastin in T-cell lines PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify plastin 3 (PLS3), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify plastin 3 (PLS3), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify plastin 3 (PLS3), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
retropepsin gag-pol A number of focal adhesion plaque proteins are specifically cleaved by HIV-1 protease, including fimbrin, focal adhesion plaque kinase (FAK), talin, and, to a lesser extent, filamin, spectrin and fibronectin PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp686G1497

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
actin filament bundle assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin filament network formation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
bone development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
actin filament IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin filament bundle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
plastin-3
Names
T fimbrin
T plastin

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012518.2 RefSeqGene

    Range
    4972..94983
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001136025.4NP_001129497.1  plastin-3 isoform 1

    See identical proteins and their annotated locations for NP_001129497.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' non-coding exon compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AA704125, BC039049, BM979335, DC357886
    Consensus CDS
    CCDS14568.1
    UniProtKB/Swiss-Prot
    P13797
    Related
    ENSP00000445339.2, ENST00000539310.5
    Conserved Domains (1) summary
    COG5069
    Location:19623
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
  2. NM_001172335.2NP_001165806.1  plastin-3 isoform 2

    See identical proteins and their annotated locations for NP_001165806.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate 5' non-coding exon, and uses an alternate in-frame donor splice site in the coding region, compared to variant 1. The encoded isoform (2) is shorter lacking an internal protein segment compared to isoform 1.
    Source sequence(s)
    AA704125, AK298530, BC039049, BM979335, DC357886
    UniProtKB/Swiss-Prot
    P13797
    UniProtKB/TrEMBL
    B4DPW9
    Conserved Domains (2) summary
    COG5069
    Location:79596
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cl08302
    Location:1649
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  3. NM_001282337.1NP_001269266.1  plastin-3 isoform 3

    See identical proteins and their annotated locations for NP_001269266.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) contains an exon in the 5' region (which results in the use of an alternate translation initiation codon) and another in-frame exon in the mid-coding region, which are not found in variant 1. The encoded isoform (3) is shorter with a distinct N-terminus, and contains a novel 9 aa protein segment compared to isoform 1.
    Source sequence(s)
    AA704125, AK294509, BC039049, BM979335, DC320695, M34427
    Consensus CDS
    CCDS78499.1
    UniProtKB/Swiss-Prot
    P13797
    Related
    ENSP00000289290.4, ENST00000289290.7
    Conserved Domains (2) summary
    COG5069
    Location:45610
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]
    cd00051
    Location:360
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  4. NM_001282338.1NP_001269267.1  plastin-3 isoform 4

    See identical proteins and their annotated locations for NP_001269267.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) contains an alternate 5' non-coding exon and a novel exon in the 5' region that results in translation initiation from an in-frame downstream start codon compared to variant 1. The encoded isoform (4) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AA704125, AK300575, BC039049, BM979335, DC357886
    UniProtKB/Swiss-Prot
    P13797
    Conserved Domains (4) summary
    smart00033
    Location:356459
    CH; Calponin homology domain
    cd00014
    Location:79194
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam13499
    Location:136
    EF-hand_7; EF-hand domain pair
    cl08302
    Location:637
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
  5. NM_005032.7NP_005023.2  plastin-3 isoform 1

    See identical proteins and their annotated locations for NP_005023.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AA704125, AK312391, BC039049, BM979335, DC320695, M34427
    Consensus CDS
    CCDS14568.1
    UniProtKB/Swiss-Prot
    P13797
    Related
    ENSP00000348163.3, ENST00000355899.7
    Conserved Domains (1) summary
    COG5069
    Location:19623
    SAC6; Ca2+-binding actin-bundling protein fimbrin/plastin (EF-Hand superfamily) [Cytoskeleton]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p12 Primary Assembly

    Range
    115560850..115650861
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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