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PLAGL1 PLAG1 like zinc finger 1 [ Homo sapiens (human) ]

Gene ID: 5325, updated on 24-Nov-2020

Summary

Official Symbol
PLAGL1provided by HGNC
Official Full Name
PLAG1 like zinc finger 1provided by HGNC
Primary source
HGNC:HGNC:9046
See related
Ensembl:ENSG00000118495 MIM:603044
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZAC; LOT1; ZAC1
Summary
This gene encodes a C2H2 zinc finger protein that functions as a suppressor of cell growth. This gene is often deleted or methylated and silenced in cancer cells. In addition, overexpression of this gene during fetal development is thought to be the causal factor for transient neonatal diabetes mellitus (TNDM). Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding two different protein isoforms. The P1 downstream promoter of this gene is imprinted, with preferential expression from the paternal allele in many tissues. [provided by RefSeq, Nov 2015]
Expression
Broad expression in placenta (RPKM 68.4), skin (RPKM 15.8) and 16 other tissues See more
Orthologs

Genomic context

See PLAGL1 in Genome Data Viewer
Location:
6q24.2
Exon count:
12
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (143940300..144064599, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (144261437..144385736, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene LTV1 ribosome biogenesis factor Neighboring gene zinc finger C2HC-type containing 1B Neighboring gene hydatidiform mole associated and imprinted Neighboring gene FKBP prolyl isomerase 7 pseudogene Neighboring gene uncharacterized LOC105378036 Neighboring gene splicing factor 3b subunit 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Copy number response

Description
Copy number response
Haploinsufficency

No evidence available (Last evaluated (2012-08-26)

ClinGen Genome Curation Page
Triplosensitivity

No evidence available (Last evaluated (2012-08-26)

ClinGen Genome Curation Page

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif downregulates the expression of pleiomorphic adenoma gene-like 1 (PLAGL1) in Vif-expression T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC126275, MGC126276, DKFZp781P1017

Gene Ontology Provided by GOA

Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
nuclear body IDA
Inferred from Direct Assay
more info
 
nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
zinc finger protein PLAGL1
Names
PLAG-like 1
lost on transformation 1
pleiomorphic adenoma gene-like 1
tumor suppressor ZAC

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_009384.2 RefSeqGene

    Range
    5000..129299
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001080951.3NP_001074420.1  zinc finger protein PLAGL1 isoform 2

    See identical proteins and their annotated locations for NP_001074420.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) initiates from the P2 promoter and differs in the 5' UTR compared to variant 2. Variants 2, 3, 4, 5, 6, 10, 12, 15, 16, 17, 18, 19, 20, 22, 23, 25, 27, and 28 all encode the same isoform (2).
    Source sequence(s)
    AI741398, AJ311395, DA675185, DA991276, EF100448
    Consensus CDS
    CCDS5202.1
    UniProtKB/Swiss-Prot
    Q9UM63
    UniProtKB/TrEMBL
    A1YLA1
    Conserved Domains (3) summary
    COG5189
    Location:29109
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    COG5236
    Location:80207
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:626
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. NM_001080952.3NP_001074421.1  zinc finger protein PLAGL1 isoform 2

    See identical proteins and their annotated locations for NP_001074421.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4, also known as P1G) initiates from the P1 promoter and differs in the 5' UTR compared to variant 2. Variants 2, 3, 4, 5, 6, 10, 12, 15, 16, 17, 18, 19, 20, 22, 23, 25, 27, and 28 all encode the same isoform (2).
    Source sequence(s)
    AI741398, AJ311395, EF100448, EF100452, U72621
    Consensus CDS
    CCDS5202.1
    UniProtKB/Swiss-Prot
    Q9UM63
    UniProtKB/TrEMBL
    A1YLA1
    Conserved Domains (3) summary
    COG5189
    Location:29109
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    COG5236
    Location:80207
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:626
    ZF_C2H2; C2H2 Zn finger [structural motif]
  3. NM_001080953.3NP_001074422.1  zinc finger protein PLAGL1 isoform 2

    See identical proteins and their annotated locations for NP_001074422.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5, also known as P1E) initiates from the P1 promoter and differs in the 5' UTR compared to variant 2. Variants 2, 3, 4, 5, 6, 10, 12, 15, 16, 17, 18, 19, 20, 22, 23, 25, 27, and 28 all encode the same isoform (2).
    Source sequence(s)
    AI741398, AJ311395, EF100448, EF100450, U72621
    Consensus CDS
    CCDS5202.1
    UniProtKB/Swiss-Prot
    Q9UM63
    UniProtKB/TrEMBL
    A1YLA1
    Related
    ENSP00000496979.1, ENST00000649307.1
    Conserved Domains (3) summary
    COG5189
    Location:29109
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    COG5236
    Location:80207
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:626
    ZF_C2H2; C2H2 Zn finger [structural motif]
  4. NM_001080954.3NP_001074423.1  zinc finger protein PLAGL1 isoform 2

    See identical proteins and their annotated locations for NP_001074423.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6, also known as P1D) initiates from the P1 promoter and differs in the 5' UTR compared to variant 2. Variants 2, 3, 4, 5, 6, 10, 12, 15, 16, 17, 18, 19, 20, 22, 23, 25, 27, and 28 all encode the same isoform (2).
    Source sequence(s)
    AI741398, AJ311395, DA595200, EF100448, EF100449, U72621
    Consensus CDS
    CCDS5202.1
    UniProtKB/Swiss-Prot
    Q9UM63
    UniProtKB/TrEMBL
    A1YLA1
    Conserved Domains (3) summary
    COG5189
    Location:29109
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    COG5236
    Location:80207
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:626
    ZF_C2H2; C2H2 Zn finger [structural motif]
  5. NM_001080955.3NP_001074424.1  zinc finger protein PLAGL1 isoform 1

    See identical proteins and their annotated locations for NP_001074424.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7, also known as P2C) initiates from the P2 promoter, differs in the 5' UTR and 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (1, also known as ZACdelta2) has a shorter N-terminus than isoform 2. Variants 7, 8, 9, 11, 13, 14, 21, 24, and 26 all encode the same isoform (1).
    Source sequence(s)
    AI741398, AJ311395, DA675185, DA991276, EF100440
    Consensus CDS
    CCDS5203.1
    UniProtKB/Swiss-Prot
    Q9UM63
    UniProtKB/TrEMBL
    A1YLA2
    Conserved Domains (3) summary
    COG5236
    Location:28155
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:7090
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:1032
    zf-C2H2; Zinc finger, C2H2 type
  6. NM_001080956.3NP_001074425.1  zinc finger protein PLAGL1 isoform 1

    See identical proteins and their annotated locations for NP_001074425.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) initiates from the P1 promoter, differs in the 5' UTR and 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (1, also known as ZACdelta2) has a shorter N-terminus than isoform 2. Variants 7, 8, 9, 11, 13, 14, 21, 24, and 26 all encode the same isoform (1).
    Source sequence(s)
    AI741398, AJ311395, DA426770
    Consensus CDS
    CCDS5203.1
    UniProtKB/Swiss-Prot
    Q9UM63
    Related
    ENSP00000395960.2, ENST00000417959.4
    Conserved Domains (3) summary
    COG5236
    Location:28155
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:7090
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:1032
    zf-C2H2; Zinc finger, C2H2 type
  7. NM_001289037.2NP_001275966.1  zinc finger protein PLAGL1 isoform 1

    See identical proteins and their annotated locations for NP_001275966.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9, also known as P2B) initiates from the P2 promoter, differs in the 5' UTR and 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (1, also known as ZACdelta2) has a shorter N-terminus than isoform 2. Variants 7, 8, 9, 11, 13, 14, 21, 24, and 26 all encode the same isoform (1).
    Source sequence(s)
    AJ311395, AW136077, DA675185, EF100439
    Consensus CDS
    CCDS5203.1
    UniProtKB/Swiss-Prot
    Q9UM63
    UniProtKB/TrEMBL
    A1YLA2
    Conserved Domains (3) summary
    COG5236
    Location:28155
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:7090
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:1032
    zf-C2H2; Zinc finger, C2H2 type
  8. NM_001289038.2NP_001275967.1  zinc finger protein PLAGL1 isoform 1

    See identical proteins and their annotated locations for NP_001275967.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11, also known as P2D) initiates from the P2 promoter, differs in the 5' UTR and 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (1, also known as ZACdelta2) has a shorter N-terminus than isoform 2. Variants 7, 8, 9, 11, 13, 14, 21, 24, and 26 all encode the same isoform (1).
    Source sequence(s)
    AJ311395, AW136077, DA675185, EF100441
    Consensus CDS
    CCDS5203.1
    UniProtKB/Swiss-Prot
    Q9UM63
    UniProtKB/TrEMBL
    A1YLA2
    Related
    ENSP00000392418.1, ENST00000437412.5
    Conserved Domains (3) summary
    COG5236
    Location:28155
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:7090
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:1032
    zf-C2H2; Zinc finger, C2H2 type
  9. NM_001289039.2NP_001275968.1  zinc finger protein PLAGL1 isoform 1

    See identical proteins and their annotated locations for NP_001275968.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13, also known as P2H) initiates from the P2 promoter, differs in the 5' UTR and 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (1, also known as ZACdelta2) has a shorter N-terminus than isoform 2. Variants 7, 8, 9, 11, 13, 14, 21, 24, and 26 all encode the same isoform (1).
    Source sequence(s)
    AJ311395, AW136077, DA675185, EF100443
    Consensus CDS
    CCDS5203.1
    UniProtKB/Swiss-Prot
    Q9UM63
    UniProtKB/TrEMBL
    A1YLA2
    Conserved Domains (3) summary
    COG5236
    Location:28155
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:7090
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:1032
    zf-C2H2; Zinc finger, C2H2 type
  10. NM_001289040.2NP_001275969.1  zinc finger protein PLAGL1 isoform 1

    See identical proteins and their annotated locations for NP_001275969.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14, also known as P2I) initiates from the P2 promoter, differs in the 5' UTR and 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (1, also known as ZACdelta2) has a shorter N-terminus than isoform 2. Variants 7, 8, 9, 11, 13, 14, 21, 24, and 26 all encode the same isoform (1).
    Source sequence(s)
    AJ311395, AW136077, DA675185, EF100439, EF100444
    Consensus CDS
    CCDS5203.1
    UniProtKB/Swiss-Prot
    Q9UM63
    UniProtKB/TrEMBL
    A1YLA2
    Conserved Domains (3) summary
    COG5236
    Location:28155
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:7090
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:1032
    zf-C2H2; Zinc finger, C2H2 type
  11. NM_001289041.2NP_001275970.1  zinc finger protein PLAGL1 isoform 1

    See identical proteins and their annotated locations for NP_001275970.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (21, also known as P1F) initiates from the P1 promoter, differs in the 5' UTR and 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (1, also known as ZACdelta2) has a shorter N-terminus than isoform 2. Variants 7, 8, 9, 11, 13, 14, 21, 24, and 26 all encode the same isoform (1).
    Source sequence(s)
    AJ311395, AW136077, DA717476, DA806571
    Consensus CDS
    CCDS5203.1
    UniProtKB/Swiss-Prot
    Q9UM63
    Conserved Domains (3) summary
    COG5236
    Location:28155
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:7090
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:1032
    zf-C2H2; Zinc finger, C2H2 type
  12. NM_001289042.2NP_001275971.1  zinc finger protein PLAGL1 isoform 2

    See identical proteins and their annotated locations for NP_001275971.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10, also known as P2A) initiates from the P2 promoter and differs in the 5' UTR compared to variant 2. Variants 2, 3, 4, 5, 6, 10, 12, 15, 16, 17, 18, 19, 20, 22, 23, 25, 27, and 28 all encode the same isoform (2).
    Source sequence(s)
    AJ311395, AW136077, DA675185, EF100438
    Consensus CDS
    CCDS5202.1
    UniProtKB/Swiss-Prot
    Q9UM63
    UniProtKB/TrEMBL
    A1YLA1
    Conserved Domains (3) summary
    COG5189
    Location:29109
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    COG5236
    Location:80207
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:626
    ZF_C2H2; C2H2 Zn finger [structural motif]
  13. NM_001289043.2NP_001275972.1  zinc finger protein PLAGL1 isoform 2

    See identical proteins and their annotated locations for NP_001275972.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12, also known as P2E) initiates from the P2 promoter and differs in the 5' UTR compared to variant 2. Variants 2, 3, 4, 5, 6, 10, 12, 15, 16, 17, 18, 19, 20, 22, 23, 25, 27, and 28 all encode the same isoform (2).
    Source sequence(s)
    AJ311395, AW136077, DA675185, EF100442
    Consensus CDS
    CCDS5202.1
    UniProtKB/Swiss-Prot
    Q9UM63
    UniProtKB/TrEMBL
    A1YLA1
    Related
    ENSP00000400929.1, ENST00000444202.5
    Conserved Domains (3) summary
    COG5189
    Location:29109
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    COG5236
    Location:80207
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:626
    ZF_C2H2; C2H2 Zn finger [structural motif]
  14. NM_001289044.2NP_001275973.1  zinc finger protein PLAGL1 isoform 2

    See identical proteins and their annotated locations for NP_001275973.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15, also known as P2J) initiates from the P2 promoter and differs in the 5' UTR compared to variant 2. Variants 2, 3, 4, 5, 6, 10, 12, 15, 16, 17, 18, 19, 20, 22, 23, 25, 27, and 28 all encode the same isoform (2).
    Source sequence(s)
    AJ311395, AW136077, DA675185, EF100445
    Consensus CDS
    CCDS5202.1
    UniProtKB/Swiss-Prot
    Q9UM63
    UniProtKB/TrEMBL
    A1YLA1
    Conserved Domains (3) summary
    COG5189
    Location:29109
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    COG5236
    Location:80207
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:626
    ZF_C2H2; C2H2 Zn finger [structural motif]
  15. NM_001289045.2NP_001275974.1  zinc finger protein PLAGL1 isoform 2

    See identical proteins and their annotated locations for NP_001275974.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16) initiates from the P1 promoter and differs in the 5' UTR compared to variant 2. Variants 2, 3, 4, 5, 6, 10, 12, 15, 16, 17, 18, 19, 20, 22, 23, 25, 27, and 28 all encode the same isoform (2).
    Source sequence(s)
    AJ311395, AK096331, AW136077, DA385311
    Consensus CDS
    CCDS5202.1
    UniProtKB/Swiss-Prot
    Q9UM63
    Related
    ENSP00000486355.1, ENST00000625622.2
    Conserved Domains (3) summary
    COG5189
    Location:29109
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    COG5236
    Location:80207
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:626
    ZF_C2H2; C2H2 Zn finger [structural motif]
  16. NM_001289046.2NP_001275975.1  zinc finger protein PLAGL1 isoform 2

    See identical proteins and their annotated locations for NP_001275975.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17) initiates from the P1 promoter and differs in the 5' UTR compared to variant 2. Variants 2, 3, 4, 5, 6, 10, 12, 15, 16, 17, 18, 19, 20, 22, 23, 25, 27, and 28 all encode the same isoform (2).
    Source sequence(s)
    AJ311395, AW136077
    Consensus CDS
    CCDS5202.1
    UniProtKB/Swiss-Prot
    Q9UM63
    Related
    ENSP00000346810.2, ENST00000354765.6
    Conserved Domains (3) summary
    COG5189
    Location:29109
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    COG5236
    Location:80207
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:626
    ZF_C2H2; C2H2 Zn finger [structural motif]
  17. NM_001289047.2NP_001275976.1  zinc finger protein PLAGL1 isoform 2

    See identical proteins and their annotated locations for NP_001275976.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (18, also known as P1A) initiates from the P1 promoter and differs in the 5' UTR compared to variant 2. Variants 2, 3, 4, 5, 6, 10, 12, 15, 16, 17, 18, 19, 20, 22, 23, 25, 27, and 28 all encode the same isoform (2).
    Source sequence(s)
    AJ311395, AW136077, DA806571, EF100446
    Consensus CDS
    CCDS5202.1
    UniProtKB/Swiss-Prot
    Q9UM63
    UniProtKB/TrEMBL
    A1YLA1
    Related
    ENSP00000400060.1, ENST00000416623.5
    Conserved Domains (3) summary
    COG5189
    Location:29109
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    COG5236
    Location:80207
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:626
    ZF_C2H2; C2H2 Zn finger [structural motif]
  18. NM_001289048.2NP_001275977.1  zinc finger protein PLAGL1 isoform 2

    See identical proteins and their annotated locations for NP_001275977.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (19, also known as P1B) initiates from the P1 promoter and differs in the 5' UTR compared to variant 2. Variants 2, 3, 4, 5, 6, 10, 12, 15, 16, 17, 18, 19, 20, 22, 23, 25, 27, and 28 all encode the same isoform (2).
    Source sequence(s)
    AJ311395, AW136077, DA806571, EF100447
    Consensus CDS
    CCDS5202.1
    UniProtKB/Swiss-Prot
    Q9UM63
    UniProtKB/TrEMBL
    A1YLA1
    Related
    ENSP00000497492.1, ENST00000649211.1
    Conserved Domains (3) summary
    COG5189
    Location:29109
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    COG5236
    Location:80207
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:626
    ZF_C2H2; C2H2 Zn finger [structural motif]
  19. NM_001289049.2NP_001275978.1  zinc finger protein PLAGL1 isoform 2

    See identical proteins and their annotated locations for NP_001275978.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (20, also known as P1C) initiates from the P1 promoter and differs in the 5' UTR compared to variant 2. Variants 2, 3, 4, 5, 6, 10, 12, 15, 16, 17, 18, 19, 20, 22, 23, 25, 27, and 28 all encode the same isoform (2).
    Source sequence(s)
    AJ311395, AW136077, DA806571, EF100448
    Consensus CDS
    CCDS5202.1
    UniProtKB/Swiss-Prot
    Q9UM63
    UniProtKB/TrEMBL
    A1YLA1
    Conserved Domains (3) summary
    COG5189
    Location:29109
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    COG5236
    Location:80207
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:626
    ZF_C2H2; C2H2 Zn finger [structural motif]
  20. NM_001317156.1NP_001304085.1  zinc finger protein PLAGL1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (22) differs in the 5' UTR compared to variant 2. Variants 2, 3, 4, 5, 6, 10, 12, 15, 16, 17, 18, 19, 20, 22, 23, 25, 27, and 28 all encode the same isoform (2).
    Source sequence(s)
    AL049844, AL109755
    Consensus CDS
    CCDS5202.1
    UniProtKB/Swiss-Prot
    Q9UM63
    Related
    ENSP00000353734.2, ENST00000360537.6
    Conserved Domains (3) summary
    COG5189
    Location:29109
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    COG5236
    Location:80207
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:626
    ZF_C2H2; C2H2 Zn finger [structural motif]
  21. NM_001317157.2NP_001304086.1  zinc finger protein PLAGL1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (23) differs in the 5' UTR compared to variant 2. Variants 2, 3, 4, 5, 6, 10, 12, 15, 16, 17, 18, 19, 20, 22, 23, 25, 27, and 28 all encode the same isoform (2).
    Source sequence(s)
    AI741398, AJ006354, AJ311395, AL109755, EF100447
    Consensus CDS
    CCDS5202.1
    UniProtKB/Swiss-Prot
    Q9UM63
    UniProtKB/TrEMBL
    A1YLA1
    Related
    ENSP00000356543.1, ENST00000367571.3
    Conserved Domains (3) summary
    COG5189
    Location:29109
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    COG5236
    Location:80207
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:626
    ZF_C2H2; C2H2 Zn finger [structural motif]
  22. NM_001317158.1NP_001304087.1  zinc finger protein PLAGL1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (24) differs in the 5' UTR and 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (1, also known as ZACdelta2) has a shorter N-terminus than isoform 2. Variants 7, 8, 9, 11, 13, 14, 21, 24, and 26 all encode the same isoform (1).
    Source sequence(s)
    AL049844, AL109755, U81992
    Consensus CDS
    CCDS5203.1
    UniProtKB/Swiss-Prot
    Q9UM63
    Related
    ENSP00000356544.1, ENST00000367572.3
    Conserved Domains (3) summary
    COG5236
    Location:28155
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:7090
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:1032
    zf-C2H2; Zinc finger, C2H2 type
  23. NM_001317159.2NP_001304088.1  zinc finger protein PLAGL1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (25) differs in the 5' UTR compared to variant 2. Variants 2, 3, 4, 5, 6, 10, 12, 15, 16, 17, 18, 19, 20, 22, 23, 25, 27, and 28 all encode the same isoform (2).
    Source sequence(s)
    AI741398, AJ311395, AL031390, DB177852, EF100448
    Consensus CDS
    CCDS5202.1
    UniProtKB/Swiss-Prot
    Q9UM63
    UniProtKB/TrEMBL
    A1YLA1
    Conserved Domains (3) summary
    COG5189
    Location:29109
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    COG5236
    Location:80207
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:626
    ZF_C2H2; C2H2 Zn finger [structural motif]
  24. NM_001317160.2NP_001304089.1  zinc finger protein PLAGL1 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (26) initiates from the P1 promoter, differs in the 5' UTR and 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (1) has a shorter N-terminus than isoform 2. Variants 7, 8, 9, 11, 13, 14, 21, 24, and 26 all encode the same isoform (1).
    Source sequence(s)
    AI741398, AJ311395, DA549753
    Consensus CDS
    CCDS5203.1
    UniProtKB/Swiss-Prot
    Q9UM63
    Related
    ENSP00000496815.1, ENST00000647880.1
    Conserved Domains (3) summary
    COG5236
    Location:28155
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:7090
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:1032
    zf-C2H2; Zinc finger, C2H2 type
  25. NM_001317161.2NP_001304090.1  zinc finger protein PLAGL1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (27) initiates from the P1 promoter and differs in the 5' UTR compared to variant 2. Variants 2, 3, 4, 5, 6, 10, 12, 15, 16, 17, 18, 19, 20, 22, 23, 25, 27, and 28 all encode the same isoform (2).
    Source sequence(s)
    AI741398, AJ311395, AL109755, DA025970
    Consensus CDS
    CCDS5202.1
    UniProtKB/Swiss-Prot
    Q9UM63
    Conserved Domains (3) summary
    COG5189
    Location:29109
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    COG5236
    Location:80207
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:626
    ZF_C2H2; C2H2 Zn finger [structural motif]
  26. NM_001317162.2NP_001304091.1  zinc finger protein PLAGL1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (28) initiates from the P1 promoter and differs in the 5' UTR compared to variant 2. Variants 2, 3, 4, 5, 6, 10, 12, 15, 16, 17, 18, 19, 20, 22, 23, 25, 27, and 28 all encode the same isoform (2).
    Source sequence(s)
    AI741398, AJ311395, DA370204
    Consensus CDS
    CCDS5202.1
    UniProtKB/Swiss-Prot
    Q9UM63
    Related
    ENSP00000501459.1, ENST00000674357.1
    Conserved Domains (3) summary
    COG5189
    Location:29109
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    COG5236
    Location:80207
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:626
    ZF_C2H2; C2H2 Zn finger [structural motif]
  27. NM_006718.5NP_006709.2  zinc finger protein PLAGL1 isoform 2

    See identical proteins and their annotated locations for NP_006709.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) initiates from the P1 promoter and encodes the longer isoform (2). Variants 2, 3, 4, 5, 6, 10, 12, 15, 16, 17, 18, 19, 20, 22, 23, 25, 27, and 28 all encode the same isoform (2).
    Source sequence(s)
    AI741398, AJ311395, DA391124, DA549753, EF100447
    Consensus CDS
    CCDS5202.1
    UniProtKB/Swiss-Prot
    Q9UM63
    UniProtKB/TrEMBL
    A1YLA1
    Conserved Domains (3) summary
    COG5189
    Location:29109
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    COG5236
    Location:80207
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:626
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    143940300..144064599 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_002656.3: Suppressed sequence

    Description
    NM_002656.3: This RefSeq was removed because currently there is insufficient support for the transcript.
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