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Plagl1 pleiomorphic adenoma gene-like 1 [ Mus musculus (house mouse) ]

Gene ID: 22634, updated on 12-May-2024

Summary

Official Symbol
Plagl1provided by MGI
Official Full Name
pleiomorphic adenoma gene-like 1provided by MGI
Primary source
MGI:MGI:1100874
See related
Ensembl:ENSMUSG00000019817 AllianceGenome:MGI:1100874
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lot1; Zac1; 2610311E24Rik
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within regulation of gene expression and skeletal muscle cell differentiation. Predicted to be located in Golgi apparatus and nuclear body. Is expressed in several structures, including alimentary system; brain; embryo mesenchyme; heart; and sensory organ. Orthologous to human PLAGL1 (PLAG1 like zinc finger 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in limb E14.5 (RPKM 270.7), CNS E11.5 (RPKM 64.6) and 8 other tissues See more
Orthologs
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Genomic context

See Plagl1 in Genome Data Viewer
Location:
10 A2; 10 4.72 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (12966576..13007438)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (13090832..13131694)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5119 Neighboring gene STARR-seq mESC enhancer starr_25807 Neighboring gene splicing factor 3b, subunit 5 Neighboring gene predicted gene, 40602 Neighboring gene STARR-seq mESC enhancer starr_25810 Neighboring gene hydatidiform mole associated and imprinted transcript Neighboring gene zinc finger, C2HC-type containing 1B Neighboring gene STARR-seq mESC enhancer starr_25812 Neighboring gene LTV1 ribosome biogenesis factor

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 
  • Targeted (2)  1 citation

General gene information

Markers

Gene Ontology Provided by MGI

Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
zinc finger protein PLAGL1
Names
zinc finger protein regulator of apoptosis and cell cycle arrest

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364643.1NP_001351572.1  zinc finger protein PLAGL1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AK142052, AK142210, BC065150
    Consensus CDS
    CCDS87960.1
    UniProtKB/TrEMBL
    Q3UQW2
    Related
    ENSMUSP00000112889.2, ENSMUST00000121325.8
    Conserved Domains (3) summary
    COG5189
    Location:29109
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:626
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:4973
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001364644.1NP_001351573.1  zinc finger protein PLAGL1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AK142052, AK142210, BC065150
    Consensus CDS
    CCDS87960.1
    UniProtKB/TrEMBL
    Q3UQW2
    Related
    ENSMUSP00000113710.2, ENSMUST00000121766.8
    Conserved Domains (3) summary
    COG5189
    Location:29109
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:626
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:4973
    zf-H2C2_2; Zinc-finger double domain
  3. NM_001364645.1NP_001351574.1  zinc finger protein PLAGL1 isoform b

    Status: VALIDATED

    Source sequence(s)
    AL691505, AL713985
    Consensus CDS
    CCDS87960.1
    UniProtKB/TrEMBL
    Q3UQW2
    Conserved Domains (3) summary
    COG5189
    Location:29109
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:626
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:4973
    zf-H2C2_2; Zinc-finger double domain
  4. NM_009538.3NP_033564.2  zinc finger protein PLAGL1 isoform a

    See identical proteins and their annotated locations for NP_033564.2

    Status: VALIDATED

    Source sequence(s)
    BC065150
    Consensus CDS
    CCDS48501.1
    UniProtKB/TrEMBL
    Q9JLQ4
    Related
    ENSMUSP00000112847.2, ENSMUST00000121646.8
    Conserved Domains (2) summary
    sd00017
    Location:626
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:4973
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    12966576..13007438
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)