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PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 [ Homo sapiens (human) ]

Gene ID: 5300, updated on 25-Nov-2021

Summary

Official Symbol
PIN1provided by HGNC
Official Full Name
peptidylprolyl cis/trans isomerase, NIMA-interacting 1provided by HGNC
Primary source
HGNC:HGNC:8988
See related
Ensembl:ENSG00000127445 MIM:601052
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DOD; UBL5
Summary
Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. This gene encodes one of the PPIases, which specifically binds to phosphorylated ser/thr-pro motifs to catalytically regulate the post-phosphorylation conformation of its substrates. The conformational regulation catalyzed by this PPIase has a profound impact on key proteins involved in the regulation of cell growth, genotoxic and other stress responses, the immune response, induction and maintenance of pluripotency, germ cell development, neuronal differentiation, and survival. This enzyme also plays a key role in the pathogenesis of Alzheimer's disease and many cancers. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011]
Expression
Ubiquitous expression in brain (RPKM 30.9), testis (RPKM 25.2) and 25 other tissues See more
Orthologs
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Genomic context

See PIN1 in Genome Data Viewer
Location:
19p13.2
Exon count:
6
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (9835318..9849689)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (9945994..9960365)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene PIN1 divergent transcript Neighboring gene ubiquitin like 5 Neighboring gene olfactomedin 2 Neighboring gene collagen type V alpha 3 chain

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif(-) expression cooperates with Pin1 resulting in the reduction of A3G levels and the decreased incorporation of A3G into virions, suggesting the interaction between HIV-1 Vif and A3G PubMed
capsid gag Phosphorylation of HIV-1 CA at serine residue 16 is involved in the HIV-1 core uncoating process. Interaction of PIN1 with the CA core within the target cells is required for the uncoating process PubMed
integrase gag-pol HIV-1 IN is incapable of binding Pin1 Y23A mutant. The catalytically inactive Pin1 C113A mutant can bind HIV-1 IN, but completely ineffective at modifying IN sensitivity to subtilisin PubMed
gag-pol Cellular Pin1 binds phosphorylated HIV-1 IN wild type and controls IN stability, but not S57A IN mutant PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ40239, FLJ77628, MGC10717

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTPase activating protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables beta-catenin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables beta-catenin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables cis-trans isomerase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables cytoskeletal motor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables mitogen-activated protein kinase kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables peptidyl-prolyl cis-trans isomerase activity EXP
Inferred from Experiment
more info
PubMed 
enables peptidyl-prolyl cis-trans isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables peptidyl-prolyl cis-trans isomerase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables peptidyl-prolyl cis-trans isomerase activity NAS
Non-traceable Author Statement
more info
PubMed 
enables peptidyl-prolyl cis-trans isomerase activity TAS
Traceable Author Statement
more info
PubMed 
enables phosphoprotein binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables phosphoserine residue binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphothreonine residue binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphothreonine residue binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables tau protein binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
 
NOT involved_in microtubule polymerization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of amyloid-beta formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of amyloid-beta formation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of cell motility IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of protein binding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of GTPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein binding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein dephosphorylation TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within positive regulation of protein phosphorylation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein peptidyl-prolyl isomerization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein peptidyl-prolyl isomerization TAS
Traceable Author Statement
more info
PubMed 
involved_in protein stabilization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein stabilization ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within regulation of cytokinesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of mitotic nuclear division TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of pathway-restricted SMAD protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of protein localization to nucleus IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of protein stability IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to hypoxia IDA
Inferred from Direct Assay
more info
PubMed 
involved_in synapse organization ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in ciliary basal body IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
located_in midbody IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus TAS
Traceable Author Statement
more info
PubMed 
is_active_in postsynaptic cytosol IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Names
PPIase Pin1
protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1
protein interacting with never in mitosis A1
rotamase Pin1
NP_006212.1
XP_011526370.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029167.1 RefSeqGene

    Range
    5001..19483
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_847

mRNA and Protein(s)

  1. NM_006221.4NP_006212.1  peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

    See identical proteins and their annotated locations for NP_006212.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes the functional protein.
    Source sequence(s)
    AK291074, BI827672, CA439440
    Consensus CDS
    CCDS12220.1
    UniProtKB/Swiss-Prot
    Q13526
    Related
    ENSP00000247970.5, ENST00000247970.9
    Conserved Domains (2) summary
    pfam00397
    Location:737
    WW; WW domain
    cl29122
    Location:51162
    Rotamase_2; PPIC-type PPIASE domain

RNA

  1. NR_038422.3 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) includes an alternate exon, compared to variant 1, resulting in a premature stop codon. The transcript is predicted to be subject to nonsense-mediated decay (NMD).
    Source sequence(s)
    BC002899, BI827672, CA439440, CD675162
  2. NR_038830.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) includes an alternate exon in the 5' region, resulting in a premature stop codon, and lacks a segment in the 3' region, compared to variant 1. The transcript is predicted to be subject to nonsense-mediated decay (NMD).
    Source sequence(s)
    BC031971, BG912418, BI827672, CA439440, CD675162
    Related
    ENST00000590540.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    9835318..9849689
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528068.2XP_011526370.1  peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 isoform X1

    Conserved Domains (3) summary
    COG0760
    Location:58164
    SurA; Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]
    pfam00397
    Location:2542
    WW; WW domain
    cl08278
    Location:56167
    Rotamase_2; PPIC-type PPIASE domain
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