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PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 [ Homo sapiens (human) ]

Gene ID: 5300, updated on 13-Jan-2019

Summary

Official Symbol
PIN1provided by HGNC
Official Full Name
peptidylprolyl cis/trans isomerase, NIMA-interacting 1provided by HGNC
Primary source
HGNC:HGNC:8988
See related
Ensembl:ENSG00000127445 MIM:601052
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DOD; UBL5
Summary
Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. This gene encodes one of the PPIases, which specifically binds to phosphorylated ser/thr-pro motifs to catalytically regulate the post-phosphorylation conformation of its substrates. The conformational regulation catalyzed by this PPIase has a profound impact on key proteins involved in the regulation of cell growth, genotoxic and other stress responses, the immune response, induction and maintenance of pluripotency, germ cell development, neuronal differentiation, and survival. This enzyme also plays a key role in the pathogenesis of Alzheimer's disease and many cancers. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011]
Expression
Ubiquitous expression in brain (RPKM 30.9), testis (RPKM 25.2) and 25 other tissues See more
Orthologs

Genomic context

See PIN1 in Genome Data Viewer
Location:
19p13.2
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (9835207..9849689)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (9945883..9960365)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100996288 Neighboring gene ubiquitin like 5 Neighboring gene olfactomedin 2 Neighboring gene collagen type V alpha 3 chain

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif(-) expression cooperates with Pin1 resulting in the reduction of A3G levels and the decreased incorporation of A3G into virions, suggesting the interaction between HIV-1 Vif and A3G PubMed
capsid gag Phosphorylation of HIV-1 CA at serine residue 16 is involved in the HIV-1 core uncoating process. Interaction of PIN1 with the CA core within the target cells is required for the uncoating process PubMed
integrase gag-pol HIV-1 IN is incapable of binding Pin1 Y23A mutant. The catalytically inactive Pin1 C113A mutant can bind HIV-1 IN, but completely ineffective at modifying IN sensitivity to subtilisin PubMed
gag-pol Cellular Pin1 binds phosphorylated HIV-1 IN wild type and controls IN stability, but not S57A IN mutant PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Antiviral mechanism by IFN-stimulated genes, organism-specific biosystem (from REACTOME)
    Antiviral mechanism by IFN-stimulated genes, organism-specific biosystemThe ISG proteins generated by IFN pathways plays key roles in the induction of innate and adaptive immune responses.
  • C-MYC pathway, organism-specific biosystem (from Pathway Interaction Database)
    C-MYC pathway, organism-specific biosystem
    C-MYC pathway
  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
  • ISG15 antiviral mechanism, organism-specific biosystem (from REACTOME)
    ISG15 antiviral mechanism, organism-specific biosystemInterferon-stimulated gene 15 (ISG15) is a member of the ubiquitin-like (Ubl) family. It is strongly induced upon exposure to type I Interferons (IFNs), viruses, bacterial LPS, and other stresses. On...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • Interferon Signaling, organism-specific biosystem (from REACTOME)
    Interferon Signaling, organism-specific biosystemInterferons (IFNs) are cytokines that play a central role in initiating immune responses, especially antiviral and antitumor effects. There are three types of IFNs:Type I (IFN-alpha, -beta and others...
  • Negative regulators of RIG-I/MDA5 signaling, organism-specific biosystem (from REACTOME)
    Negative regulators of RIG-I/MDA5 signaling, organism-specific biosystemAs with other cytokine systems, production of type I IFN is a transient process, and can be hazardous to the host if unregulated, resulting in chronic cellular toxicity or inflammatory and autoimmune...
  • PI5P Regulates TP53 Acetylation, organism-specific biosystem (from REACTOME)
    PI5P Regulates TP53 Acetylation, organism-specific biosystemUnder conditions of cellular stress, nuclear levels of phosphatidylinositol-5-phosphate (PI5P) increase and, through interaction with ING2, result in nuclear retention/accumulation of ING2. ING2 bind...
  • RIG-I-like Receptor Signaling, organism-specific biosystem (from WikiPathways)
    RIG-I-like Receptor Signaling, organism-specific biosystemViral pathogen RNA are recognized by host helicases called RIG-I-like receptors (RLRs) that include DDX58 (RIG-I), DHX58 (LGP2), IFIH1 (MDA5), SNW1, and DDX17. These RLR proteins then go on to initia...
  • RIG-I-like receptor signaling pathway, organism-specific biosystem (from KEGG)
    RIG-I-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular ...
  • RIG-I-like receptor signaling pathway, conserved biosystem (from KEGG)
    RIG-I-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular ...
  • RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways, organism-specific biosystem (from REACTOME)
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways, organism-specific biosystemRIG-I-like helicases (RLHs) the retinoic acid inducible gene-I (RIG-I) and melanoma differentiation associated gene 5 (MDA5) are RNA helicases that recognize viral RNA present within the cytoplasm. F...
  • Regulation of TP53 Activity, organism-specific biosystem (from REACTOME)
    Regulation of TP53 Activity, organism-specific biosystemProtein stability and transcriptional activity of TP53 (p53) tumor suppressor are regulated by post-translational modifications that include ubiquitination, phosphorylation, acetylation, methylation,...
  • Regulation of TP53 Activity through Acetylation, organism-specific biosystem (from REACTOME)
    Regulation of TP53 Activity through Acetylation, organism-specific biosystemTranscriptional activity of TP53 is positively regulated by acetylation of several of its lysine residues. BRD7 binds TP53 and promotes acetylation of TP53 lysine residue K382 by acetyltransferase EP...
  • Regulation of TP53 Activity through Phosphorylation, organism-specific biosystem (from REACTOME)
    Regulation of TP53 Activity through Phosphorylation, organism-specific biosystemPhosphorylation of TP53 (p53) at the N-terminal serine residues S15 and S20 plays a critical role in protein stabilization as phosphorylation at these sites interferes with binding of the ubiquitin l...
  • Transcriptional Regulation by TP53, organism-specific biosystem (from REACTOME)
    Transcriptional Regulation by TP53, organism-specific biosystemThe tumor suppressor TP53 (encoded by the gene p53) is a transcription factor. Under stress conditions, it recognizes specific responsive DNA elements and thus regulates the transcription of many gen...
  • p53 pathway, organism-specific biosystem (from Pathway Interaction Database)
    p53 pathway, organism-specific biosystem
    p53 pathway

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ40239, FLJ77628, MGC10717

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activating protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
beta-catenin binding IPI
Inferred from Physical Interaction
more info
PubMed 
beta-catenin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
mitogen-activated protein kinase kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
motor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
peptidyl-prolyl cis-trans isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-prolyl cis-trans isomerase activity IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-prolyl cis-trans isomerase activity NAS
Non-traceable Author Statement
more info
PubMed 
peptidyl-prolyl cis-trans isomerase activity TAS
Traceable Author Statement
more info
PubMed 
phosphoprotein binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
phosphoserine residue binding IDA
Inferred from Direct Assay
more info
PubMed 
phosphothreonine residue binding IDA
Inferred from Direct Assay
more info
PubMed 
phosphothreonine residue binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
tau protein binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cell cycle IEA
Inferred from Electronic Annotation
more info
 
NOT microtubule polymerization IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell motility IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
negative regulation of protein binding IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of type I interferon production TAS
Traceable Author Statement
more info
 
neuron differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of GTPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cell growth involved in cardiac muscle cell development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein binding IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein dephosphorylation TAS
Traceable Author Statement
more info
PubMed 
positive regulation of protein phosphorylation IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein peptidyl-prolyl isomerization TAS
Traceable Author Statement
more info
PubMed 
protein stabilization IDA
Inferred from Direct Assay
more info
PubMed 
protein stabilization ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cytokinesis IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
regulation of mitotic nuclear division TAS
Traceable Author Statement
more info
PubMed 
regulation of pathway-restricted SMAD protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of protein localization to nucleus IDA
Inferred from Direct Assay
more info
PubMed 
regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of signal transduction by p53 class mediator TAS
Traceable Author Statement
more info
 
synapse organization ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
midbody IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
neuron projection IEA
Inferred from Electronic Annotation
more info
 
nuclear speck IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus TAS
Traceable Author Statement
more info
PubMed 
postsynaptic cytosol IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Names
PPIase Pin1
protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1
rotamase Pin1
NP_006212.1
XP_011526370.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029167.1 RefSeqGene

    Range
    5001..19483
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_847

mRNA and Protein(s)

  1. NM_006221.3NP_006212.1  peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

    See identical proteins and their annotated locations for NP_006212.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes the functional protein.
    Source sequence(s)
    AK291074, BI827672, CA439440
    Consensus CDS
    CCDS12220.1
    UniProtKB/Swiss-Prot
    Q13526
    Related
    ENSP00000247970.4, ENST00000247970.8
    Conserved Domains (2) summary
    pfam00397
    Location:737
    WW; WW domain
    cl26124
    Location:51162
    Rotamase_2; PPIC-type PPIASE domain

RNA

  1. NR_038422.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) includes an alternate exon, compared to variant 1, resulting in a premature stop codon. The transcript is predicted to be subject to nonsense-mediated decay (NMD).
    Source sequence(s)
    BC002899, BI827672, CA439440, CD675162
  2. NR_038830.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) includes an alternate exon in the 5' region, resulting in a premature stop codon, and lacks a segment in the 3' region, compared to variant 1. The transcript is predicted to be subject to nonsense-mediated decay (NMD).
    Source sequence(s)
    BC031971, BG912418, BI827672, CA439440, CD675162
    Related
    ENST00000590540.5

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    9835207..9849689
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011528068.2XP_011526370.1  peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 isoform X1

    Conserved Domains (3) summary
    COG0760
    Location:58164
    SurA; Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]
    pfam00397
    Location:2542
    WW; WW domain
    cl08278
    Location:56167
    Rotamase_2; PPIC-type PPIASE domain
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