U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Pin1 peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1 [ Mus musculus (house mouse) ]

Gene ID: 23988, updated on 5-Mar-2024

Summary

Official Symbol
Pin1provided by MGI
Official Full Name
peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1provided by MGI
Primary source
MGI:MGI:1346036
See related
Ensembl:ENSMUSG00000032171 AllianceGenome:MGI:1346036
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D9Bwg1161e; 0610025L01Rik
Summary
Enables several functions, including beta-catenin binding activity; peptidyl-prolyl cis-trans isomerase activity; and phosphoprotein binding activity. Involved in several processes, including negative regulation of amyloid-beta formation; protein peptidyl-prolyl isomerization; and protein stabilization. Acts upstream of or within regulation of cell population proliferation and regulation of cytokinesis. Located in cytosol and nucleus. Is expressed in several structures, including 2-cell stage embryo; gut; nucleus pulposus; and reproductive system. Used to study Alzheimer's disease. Orthologous to human PIN1 (peptidylprolyl cis/trans isomerase, NIMA-interacting 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 15.3), CNS E18 (RPKM 13.4) and 28 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Pin1 in Genome Data Viewer
Location:
9 A3; 9 7.6 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (20563335..20575008)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (20652118..20663712)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene F-box and leucine-rich repeat protein 12, opposite strand Neighboring gene STARR-seq mESC enhancer starr_23463 Neighboring gene F-box and leucine-rich repeat protein 12 Neighboring gene STARR-positive B cell enhancer ABC_E458 Neighboring gene ubiquitin-like 5 Neighboring gene olfactomedin 2 Neighboring gene predicted gene, 39299 Neighboring gene predicted gene, 35860

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activating protein binding ISO
Inferred from Sequence Orthology
more info
 
enables beta-catenin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables beta-catenin binding ISO
Inferred from Sequence Orthology
more info
 
enables cis-trans isomerase activity ISO
Inferred from Sequence Orthology
more info
 
enables cytoskeletal motor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
 
enables mitogen-activated protein kinase kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables peptidyl-prolyl cis-trans isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables peptidyl-prolyl cis-trans isomerase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables peptidyl-prolyl cis-trans isomerase activity ISO
Inferred from Sequence Orthology
more info
 
enables phosphoprotein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables phosphoserine residue binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphothreonine residue binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin ligase activator activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of SMAD protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of amyloid-beta formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of amyloid-beta formation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell motility ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of canonical Wnt signaling pathway IC
Inferred by Curator
more info
PubMed 
involved_in positive regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell growth involved in cardiac muscle cell development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in protein peptidyl-prolyl isomerization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein peptidyl-prolyl isomerization ISO
Inferred from Sequence Orthology
more info
 
involved_in protein stabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of protein stability ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation protein catabolic process at postsynapse EXP
Inferred from Experiment
more info
PubMed 
involved_in regulation protein catabolic process at postsynapse IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation protein catabolic process at postsynapse IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in regulation protein catabolic process at postsynapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in synapse organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse EXP
Inferred from Experiment
more info
PubMed 
located_in glutamatergic synapse IC
Inferred by Curator
more info
PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IEP
Inferred from Expression Pattern
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 
located_in midbody ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in postsynapse IEP
Inferred from Expression Pattern
more info
PubMed 
is_active_in postsynaptic cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in synapse IEP
Inferred from Expression Pattern
more info
PubMed 

General protein information

Preferred Names
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1
Names
PPIase Pin1
peptidyl-prolyl cis-trans isomerase Pin1
protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1
rotamase Pin1
NP_001351424.1
NP_075860.1
XP_036010827.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364495.1NP_001351424.1  peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC164565
    Conserved Domains (2) summary
    pfam00397
    Location:737
    WW; WW domain
    cl26124
    Location:53129
    Rotamase_2; PPIC-type PPIASE domain
  2. NM_023371.4NP_075860.1  peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 isoform 1

    See identical proteins and their annotated locations for NP_075860.1

    Status: VALIDATED

    Source sequence(s)
    AK003931, AK054045
    Consensus CDS
    CCDS22882.1
    UniProtKB/Swiss-Prot
    Q543B3, Q9QUR7
    UniProtKB/TrEMBL
    Q3UTI7
    Related
    ENSMUSP00000034689.7, ENSMUST00000034689.8
    Conserved Domains (3) summary
    COG0760
    Location:55161
    SurA; Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]
    pfam00397
    Location:737
    WW; WW domain
    cl08278
    Location:53164
    Rotamase_2; PPIC-type PPIASE domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    20563335..20575008
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154934.1XP_036010827.1  peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 isoform X1

    Conserved Domains (2) summary
    pfam00397
    Location:737
    WW; WW domain
    cl29122
    Location:5389
    Rotamase_2; PPIC-type PPIASE domain