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PIK3C3 phosphatidylinositol 3-kinase catalytic subunit type 3 [ Homo sapiens (human) ]

Gene ID: 5289, updated on 1-Jun-2020

Summary

Official Symbol
PIK3C3provided by HGNC
Official Full Name
phosphatidylinositol 3-kinase catalytic subunit type 3provided by HGNC
Primary source
HGNC:HGNC:8974
See related
Ensembl:ENSG00000078142 MIM:602609
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
VPS34; Vps34; hVps34
Expression
Ubiquitous expression in testis (RPKM 7.2), brain (RPKM 7.0) and 25 other tissues See more
Orthologs

Genomic context

See PIK3C3 in Genome Data Viewer
Location:
18q12.3
Exon count:
27
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (41955226..42087830)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (39535165..39662272)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene chromosome 15 open reading frame 40 pseudogene Neighboring gene uncharacterized LOC105372085 Neighboring gene long intergenic non-protein coding RNA 907 Neighboring gene RNA, 5S ribosomal pseudogene 454 Neighboring gene Ras like without CAAX 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies loci affecting blood copper, selenium and zinc.
NHGRI GWA Catalog
Genome-wide association study of chronic periodontitis in a general German population.
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env CCR5 activation by gp120 triggers the assembly of endogenous Lyn, PI3K, and Pyk2 and is associated with PI3K and Pyk2 translocation from the cytoplasm to the membrane where they colocalized with Lyn PubMed
env Concomitant activation of Lyn, Pyk2, and class IA PI3K are required for gp120-induced IL-1beta production PubMed
env Insulin-like growth factor-I (IGF-I) and erythropoietin treatment protect against HIV/gp120-mediated neuronal damage in culture and in vivo, in part, through cooperative activation of phosphatidylinositol 3-kinase/Akt/GSK-3beta signaling PubMed
env HIV-1 gp120-induced TNF-alpha production by primary human macrophages is mediated by phosphatidylinositol-3 (PI-3) kinase and mitogen-activated protein (MAP) kinase pathways PubMed
env CD45 modulates HIV-1 gp120-induced apoptosis by regulating Fas ligand induction and activation of the phosphoinositide 3-kinase/Akt pathway PubMed
env Pre-treatment of endothelial cells with fibroblast growth factor 2 (FGF2) protects cells from HIV-1 gp120 angiotoxicity; this protection is regulated by crosstalk among the ERK, PI3K-AKT and PKC signaling pathways PubMed
env HIV-1 gp120-induced PI3-kinase activity and calcium mobilization are inhibited by pertussis toxin and blocking antibodies directed against CCR5 and CXCR4, suggesting that this signaling is mediated through these chemokine receptors PubMed
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 disrupts the association between phospholipase C gamma-1 and phosphoinositide 3 kinase (PI3-kinase), and this effect is dependent on PI3-kinase activity PubMed
env PI3-kinase activation induced by HIV-1 gp160 leads to downregulation of LFA-1-mediated T cell adhesion to B cells PubMed
Nef nef Downregulation of cell surface major histocompatibility complex class I (MHC-I) protein expression by HIV-1 Nef depends on a phosphoinositide 3-kinase (PI3K)-regulated signaling pathway, suggesting an interaction between Nef and PI3K PubMed
nef In the context of Nef-associated kinase complex (NAKC), hnRNP-K interacts with HIV-1 Nef and recruits LCK, PKCdelta, and PI-3 kinase PubMed
nef The presence of HIV-1 Nef in Jurkat cells stimulated with a combination of PMA and anti-CD28 upregulates the levels of PI3K production PubMed
nef The association of phosphatidylinositol (PI) 3-kinase with platelet-derived growth factor (PDGF) activated receptor was downregulated by HIV-1 nef expression PubMed
Tat tat HIV-1 Tat induces phosphorylation of PI3K, AKT, PTEN, and GSK-3beta activating PI3K and AKT and inactivating PTEN and GSK-3beta in vIL-6 expressing cells PubMed
tat HIV-1 Tat-induced upregulation of IDO production requires the activity of IFN-gamma signaling pathway such as JAK and PI3K in human monocyte derived-dendritic cells PubMed
tat Phosphatidylinositol 3-kinase/Akt signaling pathway is involved in HIV-1 Tat-induced NADPH oxidase stimulation and LTR transactivation PubMed
tat HIV-1 Tat in combination with KSHV kaposin A activates the MEK/ERK, STAT3, and PI3K/Akt signals in NIH3T3 cells PubMed
tat HIV-1 Tat-mediated cytopathic changes in human brain micro vascular endothelial cells involves its interaction with phosphatidylinositol 3-kinase (PI3K) PubMed
tat Pro-survival effects of intracellular HIV-1 Tat in a microglial cell line is attributed to activation of the PI-3-kinase (PI3K)/Akt pathway via decreasing expression of PTEN, a negative regulator of the PI-3-K pathway PubMed
tat HIV-1 Tat activates phosphatidylinositol 3-kinase (PI3K), leading to the activation of Akt/PKB, decreased levels of cAMP and CREB phosphorylation, and the protection of cells from apoptosis PubMed
tat Phosphatidylinositol 3-kinase inhibits HIV-1 Tat-mediated transactivation of the HIV-1 LTR promoter by affecting the formation of the Tat-associated kinase transactivating complex PubMed
tat HIV-1 Tat induced release of MCP-1 from human lung microvascular endothelial cells involves an interaction between Tat and PI3 kinase PubMed
tat Activation of protein kinase C-epsilon by HIV-1 Tat involves an interaction with PI 3-kinase PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC61518

Gene Ontology Provided by GOA

Function Evidence Code Pubs
1-phosphatidylinositol-3-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
1-phosphatidylinositol-3-kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
1-phosphatidylinositol-3-kinase activity TAS
Traceable Author Statement
more info
 
ATP binding IEA
Inferred from Electronic Annotation
more info
 
kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylinositol kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
autophagy of peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
cellular response to glucose starvation ISS
Inferred from Sequence or Structural Similarity
more info
 
early endosome to late endosome transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endosome organization IEA
Inferred from Electronic Annotation
more info
 
macroautophagy ISS
Inferred from Sequence or Structural Similarity
more info
 
macroautophagy TAS
Traceable Author Statement
more info
 
phosphatidylinositol biosynthetic process TAS
Traceable Author Statement
more info
 
phosphatidylinositol phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol-3-phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein lipidation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein localization to phagophore assembly site IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein processing IEA
Inferred from Electronic Annotation
more info
 
regulation of cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of protein secretion IEA
Inferred from Electronic Annotation
more info
 
response to leucine IEA
Inferred from Electronic Annotation
more info
 
toll-like receptor 9 signaling pathway TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
autolysosome IDA
Inferred from Direct Assay
more info
PubMed 
axoneme ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
late endosome IDA
Inferred from Direct Assay
more info
PubMed 
membrane HDA PubMed 
membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
midbody IDA
Inferred from Direct Assay
more info
PubMed 
peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phagocytic vesicle membrane TAS
Traceable Author Statement
more info
 
phagophore assembly site IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol 3-kinase complex, class III ISS
Inferred from Sequence or Structural Similarity
more info
 
phosphatidylinositol 3-kinase complex, class III, type I IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol 3-kinase complex, class III, type II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
phosphatidylinositol 3-kinase catalytic subunit type 3
Names
PI3-kinase type 3
PI3K type 3
PtdIns-3-kinase type 3
phosphatidylinositol 3-kinase p100 subunit
phosphoinositide-3-kinase, class 3
NP_001294949.1
NP_002638.2
XP_011524333.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308020.2NP_001294949.1  phosphatidylinositol 3-kinase catalytic subunit type 3 isoform 2

    See identical proteins and their annotated locations for NP_001294949.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC087683, AK298517, CA945171, DB450556
    Consensus CDS
    CCDS77180.1
    UniProtKB/TrEMBL
    A8MYT4, B4DPV9
    Related
    ENSP00000381845.2, ENST00000398870.7
    Conserved Domains (3) summary
    cd08397
    Location:24123
    C2_PI3K_class_III; C2 domain present in class III phosphatidylinositol 3-kinases (PI3Ks)
    cd00870
    Location:220440
    PI3Ka_III; Phosphoinositide 3-kinase (PI3K) class III, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3Ks class III ...
    cd00896
    Location:476820
    PI3Kc_III; Catalytic domain of Class III Phosphoinositide 3-kinase
  2. NM_002647.4NP_002638.2  phosphatidylinositol 3-kinase catalytic subunit type 3 isoform 1

    See identical proteins and their annotated locations for NP_002638.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC087683, BC053651, CA945171, DB450556
    Consensus CDS
    CCDS11920.1
    UniProtKB/Swiss-Prot
    Q8NEB9
    Related
    ENSP00000262039.3, ENST00000262039.9
    Conserved Domains (3) summary
    cd08397
    Location:26186
    C2_PI3K_class_III; C2 domain present in class III phosphatidylinositol 3-kinases (PI3Ks)
    cd00870
    Location:283503
    PI3Ka_III; Phosphoinositide 3-kinase (PI3K) class III, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3Ks class III ...
    cd00896
    Location:539883
    PI3Kc_III; Catalytic domain of Class III Phosphoinositide 3-kinase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

    Range
    41955226..42087830
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526031.3XP_011524333.1  phosphatidylinositol 3-kinase catalytic subunit type 3 isoform X1

    Conserved Domains (2) summary
    cd00870
    Location:97317
    PI3Ka_III; Phosphoinositide 3-kinase (PI3K) class III, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3Ks class III ...
    cd00896
    Location:353697
    PI3Kc_III; Catalytic domain of Class III Phosphoinositide 3-kinase

RNA

  1. XR_002958176.1 RNA Sequence

  2. XR_935226.1 RNA Sequence

  3. XR_001753204.2 RNA Sequence

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