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Pik3c3 phosphatidylinositol 3-kinase catalytic subunit type 3 [ Mus musculus (house mouse) ]

Gene ID: 225326, updated on 9-Oct-2018

Summary

Official Symbol
Pik3c3provided by MGI
Official Full Name
phosphatidylinositol 3-kinase catalytic subunit type 3provided by MGI
Primary source
MGI:MGI:2445019
See related
Ensembl:ENSMUSG00000033628 Vega:OTTMUSG00000021153
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Vps34; 5330434F23Rik
Expression
Broad expression in CNS E14 (RPKM 15.0), CNS E18 (RPKM 11.0) and 24 other tissues See more
Orthologs

Genomic context

See Pik3c3 in Genome Data Viewer
Location:
18; 18 B1
Exon count:
25
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 18 NC_000084.6 (30272094..30348126)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (30432550..30507774)

Chromosome 18 - NC_000084.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 41680 Neighboring gene predicted gene, 34327 Neighboring gene predicted gene 7926 Neighboring gene predicted gene 7930

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
1-phosphatidylinositol-3-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
1-phosphatidylinositol-3-kinase activity ISO
Inferred from Sequence Orthology
more info
 
ATP binding IEA
Inferred from Electronic Annotation
more info
 
kinase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol 3-kinase activity ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
autophagosome assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
autophagosome assembly ISO
Inferred from Sequence Orthology
more info
 
autophagy ISO
Inferred from Sequence Orthology
more info
PubMed 
autophagy of peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
cellular response to glucose starvation IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to starvation IMP
Inferred from Mutant Phenotype
more info
PubMed 
early endosome to late endosome transport ISO
Inferred from Sequence Orthology
more info
 
endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endosome organization ISO
Inferred from Sequence Orthology
more info
 
macroautophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphatidylinositol phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol-3-phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol-3-phosphate biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphatidylinositol-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
phosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein lipidation ISO
Inferred from Sequence Orthology
more info
PubMed 
protein localization to phagophore assembly site IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein processing ISO
Inferred from Sequence Orthology
more info
 
regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
 
regulation of protein secretion ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
autolysosome ISO
Inferred from Sequence Orthology
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
late endosome ISO
Inferred from Sequence Orthology
more info
 
membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
midbody ISO
Inferred from Sequence Orthology
more info
 
peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phagocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
phagophore assembly site IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol 3-kinase complex, class III IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylinositol 3-kinase complex, class III, type I IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylinositol 3-kinase complex, class III, type II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
phosphatidylinositol 3-kinase catalytic subunit type 3
Names
PI3-kinase type 3
PI3K type 3
phosphoinositide-3-kinase, class 3
ptdIns-3-kinase type 3
NP_852079.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181414.6NP_852079.2  phosphatidylinositol 3-kinase catalytic subunit type 3

    See identical proteins and their annotated locations for NP_852079.2

    Status: VALIDATED

    Source sequence(s)
    AC163399, AK044997, BE950444, BE980562
    Consensus CDS
    CCDS37752.1
    UniProtKB/Swiss-Prot
    Q6PF93
    Related
    ENSMUSP00000111479.3, OTTMUSP00000023341, ENSMUST00000115812.9
    Conserved Domains (3) summary
    cd08397
    Location:26186
    C2_PI3K_class_III; C2 domain present in class III phosphatidylinositol 3-kinases (PI3Ks)
    cd00870
    Location:283503
    PI3Ka_III; Phosphoinositide 3-kinase (PI3K) class III, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, PI3Ks class III ...
    cd00896
    Location:539883
    PI3Kc_III; Catalytic domain of Class III Phosphoinositide 3-kinase

RNA

  1. NR_151699.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC163399, BE980562

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000084.6 Reference GRCm38.p4 C57BL/6J

    Range
    30272094..30348126
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_385985.2 RNA Sequence

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