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PIGR polymeric immunoglobulin receptor [ Homo sapiens (human) ]

Gene ID: 5284, updated on 8-Jul-2021

Summary

Official Symbol
PIGRprovided by HGNC
Official Full Name
polymeric immunoglobulin receptorprovided by HGNC
Primary source
HGNC:HGNC:8968
See related
Ensembl:ENSG00000162896 MIM:173880
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene is a member of the immunoglobulin superfamily. The encoded poly-Ig receptor binds polymeric immunoglobulin molecules at the basolateral surface of epithelial cells; the complex is then transported across the cell to be secreted at the apical surface. A significant association was found between immunoglobulin A nephropathy and several SNPs in this gene.[provided by RefSeq, Sep 2009]
Expression
Biased expression in duodenum (RPKM 1246.3), colon (RPKM 1042.2) and 5 other tissues See more
Orthologs
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Genomic context

See PIGR in Genome Data Viewer
Location:
1q32.1
Exon count:
12
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (206928522..206946466, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (207101867..207119811, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene negCOR silencer S10 Neighboring gene ribosomal protein L13a pseudogene 8 Neighboring gene Fc fragment of IgM receptor Neighboring gene Fc fragment of IgA and IgM receptor Neighboring gene tRNA-Pro (anticodon TGG) 5-1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ22667, MGC125361, MGC125362

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables polymeric immunoglobulin receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
polymeric immunoglobulin receptor
Names
hepatocellular carcinoma associated protein TB6
poly-Ig receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012927.1 RefSeqGene

    Range
    5001..22945
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002644.4NP_002635.2  polymeric immunoglobulin receptor precursor

    See identical proteins and their annotated locations for NP_002635.2

    Status: REVIEWED

    Source sequence(s)
    AF272149, AK225471
    Consensus CDS
    CCDS1474.1
    UniProtKB/Swiss-Prot
    P01833
    Related
    ENSP00000348888.4, ENST00000356495.5
    Conserved Domains (1) summary
    cd05716
    Location:464560
    IgV_pIgR_like; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    206928522..206946466 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011509629.1XP_011507931.1  polymeric immunoglobulin receptor isoform X1

    See identical proteins and their annotated locations for XP_011507931.1

    UniProtKB/Swiss-Prot
    P01833
    Conserved Domains (1) summary
    cd05716
    Location:464560
    IgV_pIgR_like; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins
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