PIGR polymeric immunoglobulin receptor [Homo sapiens (human)] - Gene

Summary

Official Symbol: PIGRprovided by HGNC
Official Full Name: polymeric immunoglobulin receptorprovided by HGNC
Primary source: HGNC:HGNC:8968
See related: Ensembl:ENSG00000162896 MIM:173880; AllianceGenome:HGNC:8968
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: This gene is a member of the immunoglobulin superfamily. The encoded poly-Ig receptor binds polymeric immunoglobulin molecules at the basolateral surface of epithelial cells; the complex is then transported across the cell to be secreted at the apical surface. A significant association was found between immunoglobulin A nephropathy and several SNPs in this gene.[provided by RefSeq, Sep 2009]
Expression: Biased expression in duodenum (RPKM 1246.3), colon (RPKM 1042.2) and 5 other tissues See more
Orthologs: all
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Genomic context

Location:: 1q32.1

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2025_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (206928522..206946466, complement)
RS_2025_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (206193722..206211683, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (207101867..207119811, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SARS-CoV-2 Accessory Protein ORF8 Targets the Dimeric IgA Receptor pIgR.
Title: SARS-CoV-2 Accessory Protein ORF8 Targets the Dimeric IgA Receptor pIgR.
Polymeric immunoglobulin receptor (pIgR) in cancer.
Title: Polymeric immunoglobulin receptor (pIgR) in cancer.
Expression of polymeric immunoglobulin receptor (PIGR) and the effect of PIGR overexpression on breast cancer cells.
Title: Expression of polymeric immunoglobulin receptor (PIGR) and the effect of PIGR overexpression on breast cancer cells.
Polymeric immunoglobulin receptor and galectin-3-binding protein are raised in biliary atresia: Reveals a proteomic-based study.
Title: Polymeric immunoglobulin receptor and galectin-3-binding protein are raised in biliary atresia: Reveals a proteomic-based study.
Hepatic pIgR-mediated secretion of IgA limits bacterial translocation and prevents ethanol-induced liver disease in mice.
Title: Hepatic pIgR-mediated secretion of IgA limits bacterial translocation and prevents ethanol-induced liver disease in mice.
M1 macrophages evoke an increase in polymeric immunoglobulin receptor (PIGR) expression in MDA-MB468 breast cancer cells through secretion of interleukin-1beta.
Title: M1 macrophages evoke an increase in polymeric immunoglobulin receptor (PIGR) expression in MDA-MB468 breast cancer cells through secretion of interleukin-1β.
Patient pIgR-enriched extracellular vesicles drive cancer stemness, tumorigenesis and metastasis in hepatocellular carcinoma.
Title: Patient pIgR-enriched extracellular vesicles drive cancer stemness, tumorigenesis and metastasis in hepatocellular carcinoma.
Polymeric immunoglobulin receptor (PIGR) exerts oncogenic functions via activating ribosome pathway in hepatocellular carcinoma.
Title: Polymeric immunoglobulin receptor (PIGR) exerts oncogenic functions via activating ribosome pathway in hepatocellular carcinoma.
A Bioinformatic Analysis of Correlations between Polymeric Immunoglobulin Receptor (PIGR) and Liver Fibrosis Progression.
Title: A Bioinformatic Analysis of Correlations between Polymeric Immunoglobulin Receptor (PIGR) and Liver Fibrosis Progression.
High expression levels of polymeric immunoglobulin receptor are correlated with chemoresistance and poor prognosis in pancreatic cancer.
Title: High expression levels of polymeric immunoglobulin receptor are correlated with chemoresistance and poor prognosis in pancreatic cancer.

Submit: New GeneRIF Correction See all GeneRIFs (58)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

GDB:434012 (e-PCR)
- UniSTS:157204

SHGC-141724 (e-PCR)
- UniSTS:171051

D8S2278 (e-PCR)
- UniSTS:473906

D8S2279 (e-PCR)
- UniSTS:473907

SHGC-76265 (e-PCR)
- UniSTS:16445

RH69104 (e-PCR)
- UniSTS:5737

G15929 (e-PCR)
- UniSTS:66413

D1S1423 (e-PCR)
- UniSTS:149619

RH69956 (e-PCR)
- UniSTS:78979

PMC149362P1 (e-PCR)
- UniSTS:271034

PMC149362P2 (e-PCR)
- UniSTS:271035

D1S3524 (e-PCR)
- UniSTS:37078

SHGC-148408 (e-PCR)
- UniSTS:176378

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables polymeric immunoglobulin binding	IDA Inferred from Direct Assay more info	PubMed
enables polymeric immunoglobulin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Fc receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in detection of chemical stimulus involved in sensory perception of bitter taste	IDA Inferred from Direct Assay more info	PubMed
involved_in epidermal growth factor receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor	IBA Inferred from Biological aspect of Ancestor more info
involved_in immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor	IDA Inferred from Direct Assay more info	PubMed
involved_in receptor clustering	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in azurophil granule membrane	TAS Traceable Author Statement more info
located_in bounding membrane of organelle	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in endomembrane system	IEA Inferred from Electronic Annotation more info
located_in extracellular exosome	HDA more info	PubMed
located_in extracellular region	EXP Inferred from Experiment more info	PubMed
located_in extracellular region	HDA more info	PubMed
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	TAS Traceable Author Statement more info	PubMed
part_of secretory IgA immunoglobulin complex	IDA Inferred from Direct Assay more info	PubMed
part_of signaling receptor complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: polymeric immunoglobulin receptor

Names: hepatocellular carcinoma associated protein TB6; poly-Ig receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_012927.1 RefSeqGene

Range

5001..22945

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_002644.4 → NP_002635.2 polymeric immunoglobulin receptor precursor

See identical proteins and their annotated locations for NP_002635.2

Status: REVIEWED

Source sequence(s)

AF272149, AK225471

Consensus CDS

CCDS1474.1

UniProtKB/Swiss-Prot

P01833, Q68D81, Q8IZY7

UniProtKB/TrEMBL

A0ACI8PTU1

Related

ENSP00000348888.4, ENST00000356495.5

Conserved Domains (1) summary

cd05716
Location:464 → 560

IgV_pIgR_like; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000001.11 Reference GRCh38.p14 Primary Assembly

Range

206928522..206946466 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011509629.2 → XP_011507931.1 polymeric immunoglobulin receptor isoform X1

See identical proteins and their annotated locations for XP_011507931.1

UniProtKB/Swiss-Prot

P01833, Q68D81, Q8IZY7

UniProtKB/TrEMBL

A0ACI8PTU1

Related

ENSP00000530589.1, ENST00000860531.1

Conserved Domains (1) summary

cd05716
Location:464 → 560

IgV_pIgR_like; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR) and similar proteins

Alternate T2T-CHM13v2.0

Genomic

NC_060925.1 Alternate T2T-CHM13v2.0

Range

206193722..206211683 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054337031.1 → XP_054193006.1 polymeric immunoglobulin receptor isoform X1

UniProtKB/Swiss-Prot

P01833, Q68D81, Q8IZY7

UniProtKB/TrEMBL

A0ACI8PTU1