U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Pigr polymeric immunoglobulin receptor [ Mus musculus (house mouse) ]

Gene ID: 18703, updated on 18-Apr-2024

Summary

Official Symbol
Pigrprovided by MGI
Official Full Name
polymeric immunoglobulin receptorprovided by MGI
Primary source
MGI:MGI:103080
See related
Ensembl:ENSMUSG00000026417 AllianceGenome:MGI:103080
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable epidermal growth factor receptor binding activity and polymeric immunoglobulin receptor activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; detection of chemical stimulus involved in sensory perception of bitter taste; and immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor. Predicted to be located in extracellular space; recycling endosome membrane; and transport vesicle. Predicted to be part of receptor complex and secretory IgA immunoglobulin complex. Predicted to be active in plasma membrane. Orthologous to human PIGR (polymeric immunoglobulin receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in large intestine adult (RPKM 482.2), colon adult (RPKM 389.4) and 3 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Location:
1 E4; 1 56.89 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (130754421..130779986)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (130826684..130852249)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene 28856 Neighboring gene STARR-seq mESC enhancer starr_02205 Neighboring gene Fc receptor, IgA, IgM, high affinity Neighboring gene predicted gene 15848 Neighboring gene STARR-positive B cell enhancer ABC_E9184 Neighboring gene STARR-positive B cell enhancer ABC_E9478 Neighboring gene Fc fragment of IgM receptor Neighboring gene interleukin 24

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (4)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables epidermal growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables polymeric immunoglobulin binding ISO
Inferred from Sequence Orthology
more info
 
enables polymeric immunoglobulin receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in recycling endosome membrane ISO
Inferred from Sequence Orthology
more info
 
part_of secretory IgA immunoglobulin complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
polymeric immunoglobulin receptor
Names
phosphatidylinositol glycan, class R
poly-Ig receptor

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011082.3NP_035212.2  polymeric immunoglobulin receptor precursor

    See identical proteins and their annotated locations for NP_035212.2

    Status: VALIDATED

    Source sequence(s)
    AC165322, AK142656
    Consensus CDS
    CCDS15260.1
    UniProtKB/Swiss-Prot
    O70570
    Related
    ENSMUSP00000027675.8, ENSMUST00000027675.14
    Conserved Domains (3) summary
    cd05716
    Location:357456
    Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)
    smart00410
    Location:469558
    IG_like; Immunoglobulin like
    cl11960
    Location:139225
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    130754421..130779986
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)