Pigr polymeric immunoglobulin receptor [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pigrprovided by MGI
Official Full Name: polymeric immunoglobulin receptorprovided by MGI
Primary source: MGI:MGI:103080
See related: Ensembl:ENSMUSG00000026417 AllianceGenome:MGI:103080
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable epidermal growth factor receptor binding activity and polymeric immunoglobulin receptor activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; detection of chemical stimulus involved in sensory perception of bitter taste; and immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor. Predicted to be located in extracellular space; recycling endosome membrane; and transport vesicle. Predicted to be part of receptor complex and secretory IgA immunoglobulin complex. Predicted to be active in plasma membrane. Orthologous to human PIGR (polymeric immunoglobulin receptor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in large intestine adult (RPKM 482.2), colon adult (RPKM 389.4) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 E4; 1 56.89 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (130754421..130779986)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (130826684..130852249)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hepatic pIgR-mediated secretion of IgA limits bacterial translocation and prevents ethanol-induced liver disease in mice.
Title: Hepatic pIgR-mediated secretion of IgA limits bacterial translocation and prevents ethanol-induced liver disease in mice.
Exogenous and Endogenous Triggers Differentially Stimulate Pigr Expression and Antibacterial Secretory Immunity in the Murine Respiratory Tract.
Title: Exogenous and Endogenous Triggers Differentially Stimulate Pigr Expression and Antibacterial Secretory Immunity in the Murine Respiratory Tract.
RrgA, binds both polymeric immunoglobulin receptor (pIgR) and PECAM-1, whereas the choline binding protein PspC binds, but to a lower extent, only pIgR
Title: pIgR and PECAM-1 bind to pneumococcal adhesins RrgA and PspC mediating bacterial brain invasion.
pIgR/SIgA deficiency in the airways leads to persistent activation of innate immune responses to resident lung microbiota, driving progressive small airway remodelling and emphysema.
Title: Airway bacteria drive a progressive COPD-like phenotype in mice with polymeric immunoglobulin receptor deficiency.
Increased autoimmune diabetes in Pigr-deficient NOD mice is due to a "Hitchhiking" interval that refines the genetic effect of Idd5.4.
Title: Increased autoimmune diabetes in pIgR-deficient NOD mice is due to a "Hitchhiking" interval that refines the genetic effect of Idd5.4.
the polymeric immunoglobulin receptor (pIgR) is highly expressed by renal cyst-lining cells. pIgR expression is, in part, driven by aberrant STAT6 pathway activation.
Title: Exploitation of the Polymeric Immunoglobulin Receptor for Antibody Targeting to Renal Cyst Lumens in Polycystic Kidney Disease.
In a mouse intestinal explant model, the heat-inactivated potential probiotic BB6378 increases intestinal pIgR expression in a site-specific manner on the epithelium via MyD88.
Title: Upregulation of Polymeric Immunoglobulin Receptor Expression by the Heat-Inactivated Potential Probiotic Bifidobacterium bifidum OLB6378 in a Mouse Intestinal Explant Model.
pIgR on the blood-brain barrier endothelium may represent a novel pneumococcal adhesion receptor.
Title: Streptococcus pneumoniae Interacts with pIgR expressed by the brain microvascular endothelium but does not co-localize with PAF receptor.
Results reveal a novel Yes-EGFR-ERK-FIP5 signalling network for regulation of pIgA-pIgR transcytosis.
Title: A kinase cascade leading to Rab11-FIP5 controls transcytosis of the polymeric immunoglobulin receptor.
The poly immunoglobulin receptor is the main pathway for IgA transport into the male reproductive tract.
Title: Poly-immunoglobulin receptor-mediated transport of IgA into the male genital tract is important for clearance of Chlamydia muridarum infection.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AB001489 (e-PCR)
- UniSTS:178458

Pigr (e-PCR), detects polymorphism
- UniSTS:144179

PMC55698P1 (e-PCR)
- UniSTS:273350

U06431 (e-PCR)
- UniSTS:125651

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables epidermal growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables polymeric immunoglobulin binding	ISO Inferred from Sequence Orthology more info
enables polymeric immunoglobulin receptor activity	ISO Inferred from Sequence Orthology more info
enables transmembrane signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in Fc receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in detection of chemical stimulus involved in sensory perception of bitter taste	ISO Inferred from Sequence Orthology more info
involved_in epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor	IBA Inferred from Biological aspect of Ancestor more info
involved_in immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor	ISO Inferred from Sequence Orthology more info
involved_in receptor clustering	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info	PubMed
located_in recycling endosome membrane	ISO Inferred from Sequence Orthology more info
part_of secretory IgA immunoglobulin complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: polymeric immunoglobulin receptor

Names: phosphatidylinositol glycan, class R; poly-Ig receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011082.3 → NP_035212.2 polymeric immunoglobulin receptor precursor

See identical proteins and their annotated locations for NP_035212.2

Status: VALIDATED

Source sequence(s)

AC165322, AK142656

Consensus CDS

CCDS15260.1

UniProtKB/Swiss-Prot

O70570

Related

ENSMUSP00000027675.8, ENSMUST00000027675.14

Conserved Domains (3) summary

cd05716
Location:357 → 456

Ig_pIgR; Immunoglobulin (Ig)-like domain in the polymeric Ig receptor (pIgR)

smart00410
Location:469 → 558

IG_like; Immunoglobulin like

cl11960
Location:139 → 225

Ig; Immunoglobulin domain