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CALML5 calmodulin like 5 [ Homo sapiens (human) ]

Gene ID: 51806, updated on 5-Jul-2020

Summary

Official Symbol
CALML5provided by HGNC
Official Full Name
calmodulin like 5provided by HGNC
Primary source
HGNC:HGNC:18180
See related
Ensembl:ENSG00000178372 MIM:605183
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CLSP
Summary
This gene encodes a novel calcium binding protein expressed in the epidermis and related to the calmodulin family of calcium binding proteins. Functional studies with recombinant protein demonstrate it does bind calcium and undergoes a conformational change when it does so. Abundant expression is detected only in reconstructed epidermis and is restricted to differentiating keratinocytes. In addition, it can associate with transglutaminase 3, shown to be a key enzyme in the terminal differentiation of keratinocytes. [provided by RefSeq, Jul 2008]
Orthologs

Genomic context

See CALML5 in Genome Data Viewer
Location:
10p15.1
Exon count:
1
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (5498697..5499570, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (5540658..5541533, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr10.219 Neighboring gene CRISPRi-validated cis-regulatory element chr10.222 Neighboring gene CALML3 antisense RNA 1 Neighboring gene calmodulin like 3 Neighboring gene uncharacterized LOC107984169

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of CALML5 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enzyme regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
calcium-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
epidermis development TAS
Traceable Author Statement
more info
PubMed 
microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
extracellular region TAS
Traceable Author Statement
more info
 
ficolin-1-rich granule lumen TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
calmodulin-like protein 5
Names
calmodulin-like skin protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017422.5NP_059118.2  calmodulin-like protein 5

    See identical proteins and their annotated locations for NP_059118.2

    Status: REVIEWED

    Source sequence(s)
    AK222744, AL732437
    Consensus CDS
    CCDS7068.1
    UniProtKB/Swiss-Prot
    Q9NZT1
    UniProtKB/TrEMBL
    Q53H37
    Related
    ENSP00000369689.3, ENST00000380332.5
    Conserved Domains (2) summary
    PTZ00184
    Location:1143
    PTZ00184; calmodulin; Provisional
    cd00051
    Location:82144
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    5498697..5499570 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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