Format

Send to:

Choose Destination

MAP3K20 mitogen-activated protein kinase kinase kinase 20 [ Homo sapiens (human) ]

Gene ID: 51776, updated on 5-Aug-2018

Summary

Official Symbol
MAP3K20provided by HGNC
Official Full Name
mitogen-activated protein kinase kinase kinase 20provided by HGNC
Primary source
HGNC:HGNC:17797
See related
Ensembl:ENSG00000091436 MIM:609479; Vega:OTTHUMG00000132297
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
pk; AZK; MLT; MRK; ZAK; CNM6; MLK7; MLTK; SFMMP; mlklak; MLTKbeta; MLTKalpha
Summary
This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Expression
Broad expression in heart (RPKM 51.0), fat (RPKM 33.9) and 21 other tissues See more
Orthologs

Genomic context

See MAP3K20 in Genome Data Viewer
Location:
2q31.1
Exon count:
23
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (173075435..173268009)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (173940440..174132737)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene RAPGEF4 antisense RNA 1 Neighboring gene Rap guanine nucleotide exchange factor 4 Neighboring gene aldehyde dehydrogenase 7 family member A1 pseudogene 2 Neighboring gene MAP3K20 antisense RNA 1 Neighboring gene VISTA enhancer hs242 Neighboring gene uncharacterized LOC105373743 Neighboring gene ribosomal protein S2 pseudogene 18

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • MAPK Signaling Pathway, organism-specific biosystem (from WikiPathways)
    MAPK Signaling Pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, organism-specific biosystem (from KEGG)
    MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, conserved biosystem (from KEGG)
    MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • Signaling mediated by p38-gamma and p38-delta, organism-specific biosystem (from Pathway Interaction Database)
    Signaling mediated by p38-gamma and p38-delta, organism-specific biosystem
    Signaling mediated by p38-gamma and p38-delta

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
MAP kinase kinase kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
RNA binding HDA PubMed 
magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
DNA damage checkpoint IMP
Inferred from Mutant Phenotype
more info
PubMed 
activation of JUN kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
activation of MAPKK activity TAS
Traceable Author Statement
more info
PubMed 
cell cycle arrest IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell death NAS
Non-traceable Author Statement
more info
PubMed 
cell differentiation NAS
Non-traceable Author Statement
more info
PubMed 
cell proliferation NAS
Non-traceable Author Statement
more info
PubMed 
cellular response to gamma radiation IDA
Inferred from Direct Assay
more info
PubMed 
cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
embryonic digit morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
limb development IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic cell cycle checkpoint IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
stress-activated MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
mitogen-activated protein kinase kinase kinase 20
Names
HCCS-4
MLK-like mitogen-activated protein triple kinase
ZAK1 homolog, leucine zipper and sterile-alpha motif kinase
human cervical cancer suppressor gene 4 protein
mitogen-activated protein kinase kinase kinase MLT
mixed lineage kinase 7
mixed lineage kinase with a leucine zipper and a sterile alpha motif
mixed lineage kinase-related kinase MRK-beta
sterile alpha motif and leucine zipper containing kinase AZK
NP_057737.2
NP_598407.1
XP_005246697.1
XP_016859812.1
XP_016859813.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029373.1 RefSeqGene

    Range
    5001..197173
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_016653.2NP_057737.2  mitogen-activated protein kinase kinase kinase 20 isoform 1

    See identical proteins and their annotated locations for NP_057737.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1, also referred to as MRK-alpha and MLTK-alpha).
    Source sequence(s)
    AA258354, AB030034, AF251441, AF480461, AI799498, BF055268, CB955745, DA993056
    Consensus CDS
    CCDS42777.1
    UniProtKB/Swiss-Prot
    Q9NYL2
    Related
    ENSP00000364361.3, OTTHUMP00000163140, ENST00000375213.7, OTTHUMT00000255401
    Conserved Domains (3) summary
    cd09529
    Location:338408
    SAM_MLTK; SAM domain of MLTK subfamily
    smart00221
    Location:23260
    STYKc; Protein kinase; unclassified specificity
    cd14060
    Location:22263
    STKc_MLTK; Catalytic domain of the Serine/Threonine Kinase, Mixed lineage kinase-Like mitogen-activated protein Triple Kinase
  2. NM_133646.2NP_598407.1  mitogen-activated protein kinase kinase kinase 20 isoform 2

    See identical proteins and their annotated locations for NP_598407.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks several exons in the coding region and contains a different 3' exon compared to variant 1. The resulting protein (isoform 2, also referred to as MRK-beta, MLTK-beta and MLK7) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AF480462, AK056310, AL833180
    Consensus CDS
    CCDS2251.1
    UniProtKB/Swiss-Prot
    Q9NYL2
    UniProtKB/TrEMBL
    D4Q8H0
    Related
    ENSP00000340257.3, OTTHUMP00000163141, ENST00000338983.7, OTTHUMT00000255402
    Conserved Domains (1) summary
    cd14060
    Location:22263
    STKc_MLTK; Catalytic domain of the Serine/Threonine Kinase, Mixed lineage kinase-Like mitogen-activated protein Triple Kinase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    173075435..173268009
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017004324.1XP_016859813.1  mitogen-activated protein kinase kinase kinase 20 isoform X2

    UniProtKB/Swiss-Prot
    Q9NYL2
    UniProtKB/TrEMBL
    D4Q8H0
    Related
    ENSP00000439414.1, ENST00000539448.5
    Conserved Domains (1) summary
    cd14060
    Location:22263
    STKc_MLTK; Catalytic domain of the Serine/Threonine Kinase, Mixed lineage kinase-Like mitogen-activated protein Triple Kinase
  2. XM_005246640.2XP_005246697.1  mitogen-activated protein kinase kinase kinase 20 isoform X1

    See identical proteins and their annotated locations for XP_005246697.1

    UniProtKB/Swiss-Prot
    Q9NYL2
    Related
    ENSP00000387259.2, OTTHUMP00000205097, ENST00000409176.6, OTTHUMT00000333936
    Conserved Domains (3) summary
    cd09529
    Location:338408
    SAM_MLTK; SAM domain of MLTK subfamily
    smart00221
    Location:23260
    STYKc; Protein kinase; unclassified specificity
    cd14060
    Location:22263
    STKc_MLTK; Catalytic domain of the Serine/Threonine Kinase, Mixed lineage kinase-Like mitogen-activated protein Triple Kinase
  3. XM_017004323.1XP_016859812.1  mitogen-activated protein kinase kinase kinase 20 isoform X2

    UniProtKB/Swiss-Prot
    Q9NYL2
    UniProtKB/TrEMBL
    D4Q8H0
    Conserved Domains (1) summary
    cd14060
    Location:22263
    STKc_MLTK; Catalytic domain of the Serine/Threonine Kinase, Mixed lineage kinase-Like mitogen-activated protein Triple Kinase
Support Center