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Map3k20 mitogen-activated protein kinase kinase kinase 20 [ Mus musculus (house mouse) ]

Gene ID: 65964, updated on 8-Feb-2024

Summary

Official Symbol
Map3k20provided by MGI
Official Full Name
mitogen-activated protein kinase kinase kinase 20provided by MGI
Primary source
MGI:MGI:2443258
See related
Ensembl:ENSMUSG00000004085 AllianceGenome:MGI:2443258
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MRK; Zak; MLTK; HCCS-4; MLTKbeta; MLTKalpha; B230120H23Rik
Summary
Enables ATP binding activity; MAP kinase kinase kinase activity; and magnesium ion binding activity. Involved in intracellular signal transduction; limb development; and protein phosphorylation. Acts upstream of or within cytoskeleton organization and embryonic digit morphogenesis. Located in cytoplasm and nucleus. Is expressed in heart; limb; limb bud; and urinary system. Used to study split hand-foot malformation. Human ortholog(s) of this gene implicated in centronuclear myopathy 6 with fiber-type disproportion. Orthologous to human MAP3K20 (mitogen-activated protein kinase kinase kinase 20). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in heart adult (RPKM 20.9), bladder adult (RPKM 15.7) and 20 other tissues See more
Orthologs
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Genomic context

See Map3k20 in Genome Data Viewer
Location:
2 C3; 2 43.11 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (72115970..72272954)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (72285637..72442610)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene Rap guanine nucleotide exchange factor (GEF) 4 Neighboring gene STARR-seq mESC enhancer starr_04813 Neighboring gene predicted gene, 26408 Neighboring gene predicted gene, 52555 Neighboring gene STARR-positive B cell enhancer mm9_chr2:71987118-71987419 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:71995766-71995967 Neighboring gene STARR-seq mESC enhancer starr_04815 Neighboring gene predicted gene, 52556 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:72234732-72234933 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:72235096-72235279 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:72237569-72237890 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:72239438-72239655 Neighboring gene STARR-seq mESC enhancer starr_04817 Neighboring gene STARR-positive B cell enhancer ABC_E9198 Neighboring gene predicted gene, 39847 Neighboring gene cell division cycle associated 7

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ATP binding ISO
Inferred from Sequence Orthology
more info
 
enables JUN kinase kinase kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables MAP kinase kinase kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables MAP kinase kinase kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables MAP kinase kinase kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
enables magnesium ion binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein kinase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables rRNA binding IEA
Inferred from Electronic Annotation
more info
 
enables ribosome binding ISO
Inferred from Sequence Orthology
more info
 
enables small ribosomal subunit rRNA binding ISO
Inferred from Sequence Orthology
more info
 
enables stalled ribosome sensor activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in DNA damage checkpoint signaling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of GCN2-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in JNK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in JNK cascade ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within MAPK cascade IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to UV-B ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to gamma radiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in embryonic digit morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in limb development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in limb development ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of stress-activated protein kinase signaling cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of translation in response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
 
involved_in p38MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in p38MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of mitotic DNA damage checkpoint ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of positive regulation of programmed cell death ISO
Inferred from Sequence Orthology
more info
 
involved_in protein autophosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein phosphorylation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_positive_effect pyroptosis ISO
Inferred from Sequence Orthology
more info
 
involved_in stress-activated MAPK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in stress-activated MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in stress-activated protein kinase signaling cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in stress-activated protein kinase signaling cascade ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
mitogen-activated protein kinase kinase kinase 20
Names
MLK-like mitogen-activated protein triple kinase
MLK-related kinase
human cervical cancer suppressor gene 4 protein
leucine zipper- and sterile alpha motif kinase ZAK
leucine zipper- and sterile alpha motif-containing kinase
mitogen-activated protein kinase kinase kinase MLT
mixed lineage kinase-related kinase
sterile alpha motif and leucine zipper containing kinase AZK
NP_001158263.1
NP_075544.1
NP_835185.2
XP_006500060.1
XP_006500061.1
XP_030107797.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164791.2NP_001158263.1  mitogen-activated protein kinase kinase kinase 20 isoform 3

    See identical proteins and their annotated locations for NP_001158263.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks several 3' exon but has an alternate 3' exon, as compared to variant 1. The resulting isoform (3) is shorter and has a distinct C-terminus, as compared to isoform 1.
    Source sequence(s)
    AL928699
    Consensus CDS
    CCDS50605.1
    UniProtKB/TrEMBL
    Q3TRG2
    Related
    ENSMUSP00000118983.2, ENSMUST00000135469.8
    Conserved Domains (1) summary
    cd14060
    Location:22263
    STKc_MLTK; Catalytic domain of the Serine/Threonine Kinase, Mixed lineage kinase-Like mitogen-activated protein Triple Kinase
  2. NM_023057.6NP_075544.1  mitogen-activated protein kinase kinase kinase 20 isoform 1

    See identical proteins and their annotated locations for NP_075544.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL845274, AL928699
    Consensus CDS
    CCDS38143.1
    UniProtKB/Swiss-Prot
    Q3V1X8, Q8BR73, Q9ESL3, Q9ESL4
    Related
    ENSMUSP00000088334.6, ENSMUST00000090824.12
    Conserved Domains (2) summary
    cd09529
    Location:338408
    SAM_MLTK; SAM domain of MLTK subfamily
    cd14060
    Location:22263
    STKc_MLTK; Catalytic domain of the Serine/Threonine Kinase, Mixed lineage kinase-Like mitogen-activated protein Triple Kinase
  3. NM_178084.5NP_835185.2  mitogen-activated protein kinase kinase kinase 20 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks multiple 3' exon but has an alternate 3' segment, as compared to variant 1. The resulting isoform (2) is much shorter and has a distinct C-terminus, as compared to isoform 1.
    Source sequence(s)
    AL928699
    UniProtKB/Swiss-Prot
    Q9ESL4
    Related
    ENSMUST00000150126.8
    Conserved Domains (1) summary
    cd14060
    Location:22263
    STKc_MLTK; Catalytic domain of the Serine/Threonine Kinase, Mixed lineage kinase-Like mitogen-activated protein Triple Kinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    72115970..72272954
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006499997.4XP_006500060.1  mitogen-activated protein kinase kinase kinase 20 isoform X1

    See identical proteins and their annotated locations for XP_006500060.1

    UniProtKB/Swiss-Prot
    Q3V1X8, Q8BR73, Q9ESL3, Q9ESL4
    Conserved Domains (2) summary
    cd09529
    Location:338408
    SAM_MLTK; SAM domain of MLTK subfamily
    cd14060
    Location:22263
    STKc_MLTK; Catalytic domain of the Serine/Threonine Kinase, Mixed lineage kinase-Like mitogen-activated protein Triple Kinase
  2. XM_030251937.2XP_030107797.1  mitogen-activated protein kinase kinase kinase 20 isoform X3

    UniProtKB/TrEMBL
    Q3TRG2
    Conserved Domains (1) summary
    cd14060
    Location:22263
    STKc_MLTK; Catalytic domain of the Serine/Threonine Kinase, Mixed lineage kinase-Like mitogen-activated protein Triple Kinase
  3. XM_006499998.4XP_006500061.1  mitogen-activated protein kinase kinase kinase 20 isoform X2

    Conserved Domains (2) summary
    cd09529
    Location:2292
    SAM_MLTK; SAM domain of MLTK subfamily
    PTZ00112
    Location:292411
    PTZ00112; origin recognition complex 1 protein; Provisional

RNA

  1. XR_004940679.1 RNA Sequence