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PDE7A phosphodiesterase 7A [ Homo sapiens (human) ]

Gene ID: 5150, updated on 8-Dec-2018

Summary

Official Symbol
PDE7Aprovided by HGNC
Official Full Name
phosphodiesterase 7Aprovided by HGNC
Primary source
HGNC:HGNC:8791
See related
Ensembl:ENSG00000205268 MIM:171885
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HCP1; PDE7
Summary
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE7 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2011]
Expression
Broad expression in lymph node (RPKM 14.6), appendix (RPKM 7.7) and 23 other tissues See more
Orthologs

Genomic context

See PDE7A in Genome Data Viewer
Location:
8q13.1
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 8 NC_000008.11 (65714334..65841734, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (66626569..66753969, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1299 Neighboring gene armadillo repeat containing 1 Neighboring gene mitochondrial fission regulator 1 Neighboring gene uncharacterized LOC107986949 Neighboring gene uncharacterized LOC107986948 Neighboring gene uncharacterized LOC107986950 Neighboring gene uncharacterized LOC105375883 Neighboring gene DnaJ heat shock protein family (Hsp40) member C5 beta

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat decreases the intracellular levels of cAMP and CREB ser-133 phosphorylation through a signal transduction pathway involving sequential activation of phosphatidylinositol 3-kinase, AKT, and cyclic nucleoside phosphodiesterases PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Ectoderm Differentiation, organism-specific biosystem (from WikiPathways)
    Ectoderm Differentiation, organism-specific biosystemModel depicting ectoderm specification based on the literature and highly enriched gene expression profiles via comparison across dozens of independent induced and embryonic pluripotent stem cell lin...
  • G Protein Signaling Pathways, organism-specific biosystem (from WikiPathways)
    G Protein Signaling Pathways, organism-specific biosystemG proteins, short for guanine nucleotide-binding proteins, are a family of proteins involved in second messenger cascades. G proteins are so called because they function as "molecular switches". They...
  • G alpha (s) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (s) signalling events, organism-specific biosystemThe general function of the G alpha (s) subunit (Gs) is to activate adenylate cyclase, which in turn produces cAMP, leading to the activation of cAMP-dependent protein kinases (often referred to col...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • Morphine addiction, organism-specific biosystem (from KEGG)
    Morphine addiction, organism-specific biosystemMorphine is an alkaloid from the plant extracts of opium poppy. Although morphine is highly effective for the treatment of pain, it is also known to be intensely addictive. We now know that the most ...
  • Morphine addiction, conserved biosystem (from KEGG)
    Morphine addiction, conserved biosystemMorphine is an alkaloid from the plant extracts of opium poppy. Although morphine is highly effective for the treatment of pain, it is also known to be intensely addictive. We now know that the most ...
  • Purine metabolism, organism-specific biosystem (from KEGG)
    Purine metabolism, organism-specific biosystem
    Purine metabolism
  • Purine metabolism, conserved biosystem (from KEGG)
    Purine metabolism, conserved biosystem
    Purine metabolism
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
3',5'-cyclic-AMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
3',5'-cyclic-AMP phosphodiesterase activity IDA
Inferred from Direct Assay
more info
PubMed 
3',5'-cyclic-AMP phosphodiesterase activity TAS
Traceable Author Statement
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
cAMP catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
Names
TM22
phosphodiesterase isozyme 7
NP_001229247.1
NP_002594.1
XP_011515842.1
XP_016869027.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029614.1 RefSeqGene

    Range
    5001..132401
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001242318.2NP_001229247.1  high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform c

    See identical proteins and their annotated locations for NP_001229247.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3, also called PDE7A1) represents the longer transcript, and encodes the longer isoform (c).
    Source sequence(s)
    AC055822, AK057586, AK292680, AW387924, BM818331, CN414361, DB460103, DR000686, N49050
    Consensus CDS
    CCDS56538.1
    UniProtKB/Swiss-Prot
    Q13946
    Related
    ENSP00000385632.3, ENST00000401827.7
    Conserved Domains (2) summary
    pfam00233
    Location:211431
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam09195
    Location:51127
    Endonuc-BglII; Restriction endonuclease BglII
  2. NM_002603.3NP_002594.1  high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform a precursor

    See identical proteins and their annotated locations for NP_002594.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also called PDE7A2) differs in the 5' UTR and coding sequence compared to variant 3. The resulting isoform (a) has a distinct N-terminus compared to isoform c.
    Source sequence(s)
    AC055822, AK057586, AW387924, BM818331, CN414361, N49050, U67932
    Consensus CDS
    CCDS34901.1
    UniProtKB/Swiss-Prot
    Q13946
    Related
    ENSP00000368730.4, ENST00000379419.8
    Conserved Domains (2) summary
    pfam00233
    Location:185405
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam09195
    Location:16101
    Endonuc-BglII; Restriction endonuclease BglII

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p12 Primary Assembly

    Range
    65714334..65841734 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011517540.3XP_011515842.1  high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X1

    See identical proteins and their annotated locations for XP_011515842.1

    UniProtKB/Swiss-Prot
    Q13946
    Conserved Domains (2) summary
    pfam00233
    Location:185405
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam09195
    Location:16101
    Endonuc-BglII; Restriction endonuclease BglII
  2. XM_017013538.2XP_016869027.1  high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_002604.2: Suppressed sequence

    Description
    NM_002604.2: This RefSeq was permanently suppressed because its 3' end is primarily intronic sequence.
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