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PDE7A phosphodiesterase 7A [ Homo sapiens (human) ]

Gene ID: 5150, updated on 5-Mar-2024

Summary

Official Symbol
PDE7Aprovided by HGNC
Official Full Name
phosphodiesterase 7Aprovided by HGNC
Primary source
HGNC:HGNC:8791
See related
Ensembl:ENSG00000205268 MIM:171885; AllianceGenome:HGNC:8791
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HCP1; PDE7
Summary
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE7 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2011]
Expression
Broad expression in lymph node (RPKM 14.6), appendix (RPKM 7.7) and 23 other tissues See more
Orthologs
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Genomic context

See PDE7A in Genome Data Viewer
Location:
8q13.1
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (65714334..65842064, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (66140012..66267737, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (66626569..66754299, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1299 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:66472804-66473503 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:66528344-66529126 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr8:66546245-66546867 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27461 Neighboring gene armadillo repeat containing 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27462 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19245 Neighboring gene mitochondrial fission regulator 1 Neighboring gene MPRA-validated peak7054 silencer Neighboring gene uncharacterized LOC107986949 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27463 Neighboring gene MPRA-validated peak7055 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27464 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:66752860-66753429 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:66753430-66753998 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:66753999-66754568 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:66754569-66755137 Neighboring gene MPRA-validated peak7056 silencer Neighboring gene PDE7A divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27465 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:66842558-66843076 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:66843077-66843595 Neighboring gene uncharacterized LOC107986950 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27466 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27467 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27468 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27469 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr8:66862529-66863728

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat decreases the intracellular levels of cAMP and CREB ser-133 phosphorylation through a signal transduction pathway involving sequential activation of phosphatidylinositol 3-kinase, AKT, and cyclic nucleoside phosphodiesterases PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables 3',5'-cyclic-AMP phosphodiesterase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables 3',5'-cyclic-GMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cAMP catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cAMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cAMP-mediated signaling IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
high affinity 3',5'-cyclic-AMP phosphodiesterase 7A; high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
Names
TM22
cAMP-specific phosphodiesterase 7A
high affinity cAMP-specific PDE 1
phosphodiesterase isozyme 7
NP_001229247.1
NP_002594.1
XP_011515842.1
XP_016869027.1
XP_054216608.1
XP_054216609.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029614.1 RefSeqGene

    Range
    4671..132401
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001242318.3NP_001229247.1  high affinity 3',5'-cyclic-AMP phosphodiesterase 7A isoform c

    See identical proteins and their annotated locations for NP_001229247.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3, also called PDE7A1) represents the longer transcript, and encodes the longer isoform (c).
    Source sequence(s)
    AC055822, AC100812, AK057586, AK292680, AW387924, BM818331, CN414361, DB460103, DR000686, N49050
    Consensus CDS
    CCDS56538.1
    UniProtKB/Swiss-Prot
    A0AVH6, A8K436, A8K9G5, O15380, Q13946, Q96T72
    Related
    ENSP00000385632.4, ENST00000401827.8
    Conserved Domains (1) summary
    pfam00233
    Location:211444
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  2. NM_002603.4NP_002594.1  high affinity 3',5'-cyclic-AMP phosphodiesterase 7A isoform a

    See identical proteins and their annotated locations for NP_002594.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also called PDE7A2) differs in the 5' UTR and coding sequence compared to variant 3. The resulting isoform (a) has a distinct N-terminus compared to isoform c.
    Source sequence(s)
    AC055822, AK057586, AW387924, BM818331, CN414361, N49050, U67932
    Consensus CDS
    CCDS34901.1
    Related
    ENSP00000368730.4, ENST00000379419.8
    Conserved Domains (2) summary
    pfam00233
    Location:185405
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam09195
    Location:16101
    Endonuc-BglII; Restriction endonuclease BglII

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    65714334..65842064 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011517540.4XP_011515842.1  high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X1

    See identical proteins and their annotated locations for XP_011515842.1

    Conserved Domains (2) summary
    pfam00233
    Location:185405
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam09195
    Location:16101
    Endonuc-BglII; Restriction endonuclease BglII
  2. XM_017013538.3XP_016869027.1  high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    66140012..66267737 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054360633.1XP_054216608.1  high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X1

  2. XM_054360634.1XP_054216609.1  high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_002604.2: Suppressed sequence

    Description
    NM_002604.2: This RefSeq was permanently suppressed because its 3' end is primarily intronic sequence.