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Pde7a phosphodiesterase 7A [ Mus musculus (house mouse) ]

Gene ID: 18583, updated on 5-Jan-2023

Summary

Official Symbol
Pde7aprovided by MGI
Official Full Name
phosphodiesterase 7Aprovided by MGI
Primary source
MGI:MGI:1202402
See related
Ensembl:ENSMUSG00000069094 AllianceGenome:MGI:1202402
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable 3',5'-cyclic-AMP phosphodiesterase activity. Predicted to be involved in cAMP-mediated signaling. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and sensory organ. Orthologous to human PDE7A (phosphodiesterase 7A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 11.8), whole brain E14.5 (RPKM 10.9) and 24 other tissues See more
Orthologs
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Genomic context

See Pde7a in Genome Data Viewer
Location:
3 A2; 3 5.36 cM
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (19277272..19365486, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (19223108..19311322, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene armadillo repeat containing 1 Neighboring gene mitochondrial fission regulator 1 Neighboring gene testis-specific gene A8 protein-like Neighboring gene predicted gene, 52602 Neighboring gene predicted gene, 42188

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables 3',5'-cyclic-AMP phosphodiesterase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables 3',5'-cyclic-AMP phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables 3',5'-cyclic-nucleotide phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
 
enables cyclic-nucleotide phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphoric diester hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cAMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cAMP-mediated signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cAMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A
NP_001116231.1
NP_032828.2
XP_006535468.1
XP_006535469.1
XP_006535471.1
XP_030108316.1
XP_036018817.1
XP_036018818.1
XP_036018819.1
XP_036018820.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122759.2NP_001116231.1  high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform 2

    See identical proteins and their annotated locations for NP_001116231.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon, lacks a portion of the 5' coding region and initiates translation at an alternate start codon compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is longer than isoform 1.
    Source sequence(s)
    AC102756, AC127283, AK036517, BC062909
    Consensus CDS
    CCDS50871.1
    UniProtKB/Swiss-Prot
    P70453
    UniProtKB/TrEMBL
    Q3U3Y7, Q6P5G2
    Related
    ENSMUSP00000096800.4, ENSMUST00000099195.10
    Conserved Domains (2) summary
    pfam00233
    Location:211431
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam09195
    Location:51128
    Endonuc-BglII; Restriction endonuclease BglII
  2. NM_008802.3NP_032828.2  high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform 1 precursor

    See identical proteins and their annotated locations for NP_032828.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (1).
    Source sequence(s)
    AC127283, AK036517, CV558025
    Consensus CDS
    CCDS38398.1
    UniProtKB/Swiss-Prot
    P70453, Q9ERB3
    Related
    ENSMUSP00000088863.5, ENSMUST00000091314.11
    Conserved Domains (2) summary
    pfam00233
    Location:185405
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam09195
    Location:16102
    Endonuc-BglII; Restriction endonuclease BglII

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    19277272..19365486 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162924.1XP_036018817.1  high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X3

    Conserved Domains (1) summary
    pfam00233
    Location:65285
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  2. XM_036162925.1XP_036018818.1  high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X3

    Conserved Domains (1) summary
    pfam00233
    Location:65285
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  3. XM_006535405.4XP_006535468.1  high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X1

    Conserved Domains (1) summary
    pfam00233
    Location:206426
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  4. XM_006535408.5XP_006535471.1  high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X4

    Conserved Domains (1) summary
    pfam00233
    Location:21241
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  5. XM_036162926.1XP_036018819.1  high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X3

    Conserved Domains (1) summary
    pfam00233
    Location:65285
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  6. XM_036162927.1XP_036018820.1  high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X4

    Conserved Domains (1) summary
    pfam00233
    Location:21241
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  7. XM_030252456.2XP_030108316.1  high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X4

    Conserved Domains (1) summary
    pfam00233
    Location:21241
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
  8. XM_006535406.5XP_006535469.1  high affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A isoform X2

    Conserved Domains (1) summary
    pfam00233
    Location:183403
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

RNA

  1. XR_004941293.1 RNA Sequence

  2. XR_389588.5 RNA Sequence