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NIP7 NIP7, nucleolar pre-rRNA processing protein [ Homo sapiens (human) ]

Gene ID: 51388, updated on 13-Jan-2019

Summary

Official Symbol
NIP7provided by HGNC
Official Full Name
NIP7, nucleolar pre-rRNA processing proteinprovided by HGNC
Primary source
HGNC:HGNC:24328
See related
Ensembl:ENSG00000132603
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KD93; CGI-37; HSPC031
Expression
Ubiquitous expression in lymph node (RPKM 9.5), appendix (RPKM 8.7) and 25 other tissues See more
Orthologs

Genomic context

See NIP7 in Genome Data Viewer
Location:
16q22.1
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (69339512..69343111)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (69373415..69377014)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene vacuolar protein sorting 4 homolog A Neighboring gene component of oligomeric golgi complex 8 Neighboring gene peptide deformylase, mitochondrial Neighboring gene transmembrane p24 trafficking protein 6 Neighboring gene telomeric repeat binding factor 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Expression of HIV-1 Tat upregulates the abundance of nuclear import 7 homolog (NIP7) in the nucleoli of Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10296

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
ribosomal large subunit biogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ribosome assembly IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
 
preribosome, large subunit precursor IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
60S ribosome subunit biogenesis protein NIP7 homolog
Names
nuclear import 7 homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199434.1NP_001186363.1  60S ribosome subunit biogenesis protein NIP7 homolog isoform 2

    See identical proteins and their annotated locations for NP_001186363.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AF161528, AW001672, BC015941, DB453898, DR423435
    Consensus CDS
    CCDS56003.1
    UniProtKB/Swiss-Prot
    Q9Y221
    Related
    ENSP00000254941.6, ENST00000254941.6
    Conserved Domains (1) summary
    cl00607
    Location:1129
    PUA; PUA domain
  2. NM_016101.5NP_057185.1  60S ribosome subunit biogenesis protein NIP7 homolog isoform 1

    See identical proteins and their annotated locations for NP_057185.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AW001672, BC015941, DB453898, DR423435
    Consensus CDS
    CCDS10877.1
    UniProtKB/Swiss-Prot
    Q9Y221
    Related
    ENSP00000254940.5, ENST00000254940.9
    Conserved Domains (1) summary
    COG1374
    Location:1176
    NIP7; Rbosome biogenesis protein Nip4, contains PUA domain [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

    Range
    69339512..69343111
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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