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Nip7 NIP7, nucleolar pre-rRNA processing protein [ Mus musculus (house mouse) ]

Gene ID: 66164, updated on 5-Mar-2024

Summary

Official Symbol
Nip7provided by MGI
Official Full Name
NIP7, nucleolar pre-rRNA processing proteinprovided by MGI
Primary source
MGI:MGI:1913414
See related
Ensembl:ENSMUSG00000031917 AllianceGenome:MGI:1913414
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PEachy; 1110017C15Rik; 6330509M23Rik
Summary
Predicted to enable RNA binding activity. Predicted to be involved in ribosomal large subunit biogenesis. Predicted to act upstream of or within ribosome biogenesis. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of preribosome, large subunit precursor. Predicted to be active in nucleolus. Is expressed in several structures, including alimentary system; central nervous system; liver; nasal cavity epithelium; and vibrissa. Orthologous to human NIP7 (nucleolar pre-rRNA processing protein NIP7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 14.3), placenta adult (RPKM 13.2) and 28 other tissues See more
Orthologs
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Genomic context

See Nip7 in Genome Data Viewer
Location:
8 D3; 8 53.57 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (107783509..107787563)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (107056877..107060931)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene peptide deformylase (mitochondrial) Neighboring gene component of oligomeric golgi complex 8 Neighboring gene STARR-positive B cell enhancer ABC_E3804 Neighboring gene transmembrane p24 trafficking protein 6 Neighboring gene telomeric repeat binding factor 2 Neighboring gene predicted gene, 50601

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in ribosomal large subunit biogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in ribosome assembly IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of preribosome, large subunit precursor IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
60S ribosome subunit biogenesis protein NIP7 homolog
Names
kDa93
nuclear import 7 homolog
nucleolar pre-rRNA processing protein NIP7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164472.1NP_001157944.1  60S ribosome subunit biogenesis protein NIP7 homolog isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AC123868
    Consensus CDS
    CCDS52665.1
    UniProtKB/TrEMBL
    E9Q109
    Related
    ENSMUSP00000126153.2, ENSMUST00000170962.3
    Conserved Domains (1) summary
    cl00607
    Location:1129
    PUA; PUA domain
  2. NM_025391.2NP_079667.2  60S ribosome subunit biogenesis protein NIP7 homolog isoform 1

    See identical proteins and their annotated locations for NP_079667.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC123868, AK003739, AK014290
    Consensus CDS
    CCDS22644.1
    UniProtKB/Swiss-Prot
    Q9CXK8, Q9D1B4
    Related
    ENSMUSP00000034392.6, ENSMUST00000034392.13
    Conserved Domains (1) summary
    COG1374
    Location:1176
    NIP7; Rbosome biogenesis protein Nip4, contains PUA domain [Translation, ribosomal structure and biogenesis]

RNA

  1. NR_028367.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) includes an additional segment, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC123868, BE623972

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    107783509..107787563
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)