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EIF3L eukaryotic translation initiation factor 3 subunit L [ Homo sapiens (human) ]

Gene ID: 51386, updated on 6-Nov-2022

Summary

Official Symbol
EIF3Lprovided by HGNC
Official Full Name
eukaryotic translation initiation factor 3 subunit Lprovided by HGNC
Primary source
HGNC:HGNC:18138
See related
Ensembl:ENSG00000100129 MIM:619197; AllianceGenome:HGNC:18138
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EIF3EIP; EIF3S11; HSPC021; HSPC025; MSTP005; EIF3S6IP
Summary
Enables RNA binding activity. Contributes to translation initiation factor activity. Involved in translational initiation and viral translational termination-reinitiation. Located in membrane. Part of eukaryotic translation initiation factor 3 complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary (RPKM 248.8), thyroid (RPKM 164.0) and 25 other tissues See more
Orthologs
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Genomic context

See EIF3L in Genome Data Viewer
Location:
22q13.1
Exon count:
13
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (37849419..37889407)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (38311024..38351034)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (38245426..38285414)

Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene ankyrin repeat domain 54 Neighboring gene microRNA 658 Neighboring gene microRNA 659 Neighboring gene RNA, U6 small nuclear 900, pseudogene Neighboring gene MICAL like 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pol gag-pol HIV-1 Pol is identified to have a physical interaction with eukaryotic translation initiation factor 3, subunit L (EIF3L) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with eukaryotic translation initiation factor 3, subunit L (EIF3L) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 
part_of eukaryotic 43S preinitiation complex IEA
Inferred from Electronic Annotation
more info
 
part_of eukaryotic 48S preinitiation complex IEA
Inferred from Electronic Annotation
more info
 
part_of eukaryotic translation initiation factor 3 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of eukaryotic translation initiation factor 3 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of eukaryotic translation initiation factor 3 complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in fibrillar center IEA
Inferred from Electronic Annotation
more info
 
located_in membrane HDA PubMed 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
eukaryotic translation initiation factor 3 subunit L
Names
eIEF associated protein HSPC021
eukaryotic translation initiation factor 3 subunit 6-interacting protein
eukaryotic translation initiation factor 3 subunit E-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242923.2NP_001229852.1  eukaryotic translation initiation factor 3 subunit L isoform 2

    See identical proteins and their annotated locations for NP_001229852.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two consecutive exons in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AK302346, AL022311, CD638692, DA663575, Z97630
    Consensus CDS
    CCDS56230.1
    UniProtKB/Swiss-Prot
    Q9Y262
    Related
    ENSP00000371099.4, ENST00000381683.10
    Conserved Domains (1) summary
    pfam10255
    Location:146502
    Paf67; RNA polymerase I-associated factor PAF67
  2. NM_001363785.2NP_001350714.1  eukaryotic translation initiation factor 3 subunit L isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL022311, BC029265, DA947257
    Consensus CDS
    CCDS87024.1
    UniProtKB/TrEMBL
    B0QY90
    Related
    ENSP00000384634.1, ENST00000406934.5
    Conserved Domains (1) summary
    pfam10255
    Location:54452
    Paf67; RNA polymerase I-associated factor PAF67
  3. NM_016091.4NP_057175.1  eukaryotic translation initiation factor 3 subunit L isoform 1

    See identical proteins and their annotated locations for NP_057175.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL022311, BC029265, DA051005
    Consensus CDS
    CCDS13960.1
    UniProtKB/Swiss-Prot
    Q6ICD2, Q9Y262
    Related
    ENSP00000499067.1, ENST00000652021.1
    Conserved Domains (1) summary
    pfam10255
    Location:152550
    Paf67; RNA polymerase I-associated factor PAF67

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

    Range
    37849419..37889407
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006724260.5XP_006724323.2  eukaryotic translation initiation factor 3 subunit L isoform X1

  2. XM_047441389.1XP_047297345.1  eukaryotic translation initiation factor 3 subunit L isoform X2

    UniProtKB/TrEMBL
    B0QY90
  3. XM_047441390.1XP_047297346.1  eukaryotic translation initiation factor 3 subunit L isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060946.1 Alternate T2T-CHM13v2.0

    Range
    38311024..38351034
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)