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Eif3l eukaryotic translation initiation factor 3, subunit L [ Mus musculus (house mouse) ]

Gene ID: 223691, updated on 5-Mar-2024

Summary

Official Symbol
Eif3lprovided by MGI
Official Full Name
eukaryotic translation initiation factor 3, subunit Lprovided by MGI
Primary source
MGI:MGI:2386251
See related
Ensembl:ENSMUSG00000033047 AllianceGenome:MGI:2386251
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PAF67; D15N1e; Eif3ip; Eif3eip; HSP-66Y; Eif3s6ip; 0610011H21Rik
Summary
Contributes to translation initiation factor activity. Involved in translational initiation. Located in fibrillar center and nucleoplasm. Part of eukaryotic translation initiation factor 3 complex. Is expressed in thymus primordium. Orthologous to human EIF3L (eukaryotic translation initiation factor 3 subunit L). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in placenta adult (RPKM 103.9), ovary adult (RPKM 96.4) and 28 other tissues See more
Orthologs
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Genomic context

See Eif3l in Genome Data Viewer
Location:
15 E1; 15 37.7 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (78959423..78978600)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (79075223..79094400)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene 3924 Neighboring gene ankyrin repeat domain 54 Neighboring gene STARR-positive B cell enhancer ABC_E1482 Neighboring gene STARR-seq mESC enhancer starr_39166 Neighboring gene microtubule associated monooxygenase, calponin and LIM domain containing -like 1 Neighboring gene RIKEN cDNA 1700088E04 gene Neighboring gene STARR-positive B cell enhancer ABC_E7388 Neighboring gene polymerase (RNA) II (DNA directed) polypeptide F

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC37328

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to translation initiation factor activity IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to translation initiation factor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within translation IEA
Inferred from Electronic Annotation
more info
 
involved_in translational initiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in translational initiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in translational initiation ISO
Inferred from Sequence Orthology
more info
 
involved_in viral translational termination-reinitiation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
part_of eukaryotic translation initiation factor 3 complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of eukaryotic translation initiation factor 3 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of eukaryotic translation initiation factor 3 complex ISO
Inferred from Sequence Orthology
more info
 
located_in fibrillar center IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
eukaryotic translation initiation factor 3 subunit L
Names
66 kDa tyrosine-rich heat shock protein
67 kDa polymerase-associated factor
eukaryotic translation initiation factor 3 subunit 6-interacting protein
eukaryotic translation initiation factor 3 subunit E-interacting protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145139.2NP_660121.2  eukaryotic translation initiation factor 3 subunit L

    See identical proteins and their annotated locations for NP_660121.2

    Status: VALIDATED

    Source sequence(s)
    AK075584
    Consensus CDS
    CCDS27632.1
    UniProtKB/Swiss-Prot
    Q3THF8, Q3TJ04, Q8QZY1, Q91YE4
    Related
    ENSMUSP00000038839.5, ENSMUST00000040518.6
    Conserved Domains (1) summary
    pfam10255
    Location:152550
    Paf67; RNA polymerase I-associated factor PAF67

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    78959423..78978600
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)