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RAB9B RAB9B, member RAS oncogene family [ Homo sapiens (human) ]

Gene ID: 51209, updated on 18-Aug-2020

Summary

Official Symbol
RAB9Bprovided by HGNC
Official Full Name
RAB9B, member RAS oncogene familyprovided by HGNC
Primary source
HGNC:HGNC:14090
See related
Ensembl:ENSG00000123570 Ensembl:ENSG00000288597 MIM:300285
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RAB9L; Rab-9L
Summary
This gene encodes a member of a subfamily of RAS small guanosine triphosphate (GTP)-binding proteins that regulate membrane trafficking. The encoded protein may be involved in endosome-to-Golgi transport. [provided by RefSeq, Jan 2010]
Expression
Broad expression in heart (RPKM 9.1), brain (RPKM 5.8) and 15 other tissues See more
Orthologs

Genomic context

See RAB9B in Genome Data Viewer
Location:
Xq22.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (103776324..103832257, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (103077255..103087212, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene glycine receptor alpha 4 (pseudogene) Neighboring gene transmembrane protein 31 Neighboring gene uncharacterized LOC107985661 Neighboring gene proteolipid protein 1 Neighboring gene RNA, 5S ribosomal pseudogene 511 Neighboring gene TMSB15B antisense RNA 1 Neighboring gene H2B histone pseudogene 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag HIV-1 Gag co-localizes with Rab7-, Rab9-, and LAMP1-containing membranes at cytoplasmic and juxtanuclear sites in Staufen1-depleted cells PubMed
gag Depletion of Rab9 by siRNA sequesters HIV-1 Gag within cells and causes a reduction in particle release PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GDP binding IDA
Inferred from Direct Assay
more info
PubMed 
GTP binding IEA
Inferred from Electronic Annotation
more info
 
GTPase activity IEA
Inferred from Electronic Annotation
more info
 
identical protein binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Rab protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
protein transport IEA
Inferred from Electronic Annotation
more info
 
retrograde transport, endosome to Golgi IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytosol IEA
Inferred from Electronic Annotation
more info
 
late endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lysosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phagocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phagocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
phagocytic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
secretory granule membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
ras-related protein Rab-9B
Names
Ras-associated protein 9B
Ras-associated protein RAB9-like

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016452.2 RefSeqGene

    Range
    5026..14956
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_016370.4NP_057454.1  ras-related protein Rab-9B

    See identical proteins and their annotated locations for NP_057454.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the protein.
    Source sequence(s)
    AK313425, DA501604, FO393406
    Consensus CDS
    CCDS14515.1
    UniProtKB/Swiss-Prot
    Q9NP90
    Related
    ENSP00000243298.2, ENST00000243298.3
    Conserved Domains (1) summary
    cd04116
    Location:3172
    Rab9; Rab GTPase family 9 (Rab9)

RNA

  1. NR_146558.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' exon structure compared to variant 1, and is represented as non-coding because it lacks the open reading frame found in variant 1.
    Source sequence(s)
    FO393406, Z73964
  2. NR_146560.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 3' exon structure compared to variant 1, and is represented as non-coding because it lacks the open reading frame found in variant 1.
    Source sequence(s)
    FO393406, Z73964
    Related
    ENST00000674265.1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    103776324..103832257 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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